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Protein

Intercellular adhesion molecule 5

Gene

ICAM5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 5
Short name:
ICAM-5
Alternative name(s):
Telencephalin
Gene namesi
Name:ICAM5
Synonyms:TLCN
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 826797ExtracellularSequence analysisAdd
BLAST
Transmembranei827 – 84721HelicalSequence analysisAdd
BLAST
Topological domaini848 – 91265CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 912883Intercellular adhesion molecule 5PRO_0000014801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) (high mannose)By similarity
Disulfide bondi54 ↔ 97PROSITE-ProRule annotation
Disulfide bondi58 ↔ 101PROSITE-ProRule annotation
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi139 ↔ 195PROSITE-ProRule annotation
Modified residuei179 – 1791PhosphothreonineBy similarity
Modified residuei181 – 1811PhosphothreonineBy similarity
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi246 ↔ 297PROSITE-ProRule annotation
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi339 ↔ 378PROSITE-ProRule annotation
Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence analysis
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi410 ↔ 465PROSITE-ProRule annotation
Disulfide bondi493 ↔ 546PROSITE-ProRule annotation
Disulfide bondi573 ↔ 638PROSITE-ProRule annotation
Glycosylationi576 – 5761N-linked (GlcNAc...)Sequence analysis
Glycosylationi639 – 6391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi666 ↔ 717PROSITE-ProRule annotation
Glycosylationi756 – 7561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi761 ↔ 806PROSITE-ProRule annotation
Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence analysis
Glycosylationi788 – 7881N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylation at Asn-53 is critical for functional folding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

Structurei

3D structure databases

ProteinModelPortaliQ28730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 12781Ig-like C2-type 1Add
BLAST
Domaini132 – 232101Ig-like C2-type 2Add
BLAST
Domaini239 – 32486Ig-like C2-type 3Add
BLAST
Domaini332 – 39564Ig-like C2-type 4Add
BLAST
Domaini403 – 48179Ig-like C2-type 5Add
BLAST
Domaini486 – 56176Ig-like C2-type 6Add
BLAST
Domaini566 – 64580Ig-like C2-type 7Add
BLAST
Domaini659 – 73476Ig-like C2-type 8Add
BLAST
Domaini738 – 81982Ig-like C2-type 9Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052077.
InParanoidiQ28730.
KOiK06769.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 9 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPSPGLRA LLGFWVALGL GILRLSAVAQ EPFWADLQPR VALVERGGSL
60 70 80 90 100
WLNCSTNCPR PERGGLETSL RRNGPEGLRW RARQLVDIRE PETQPVCFFR
110 120 130 140 150
CAATLQARGL IRTFQRPDRV ELVPLPPWQP VGENFTLSCR VPGAGPRGSL
160 170 180 190 200
TLTLLRGAQE LIRRSFAGEP ARARGAVLTA TVLARREDHG ANFSCRAELD
210 220 230 240 250
LRPQGLALFE NSSAPRQLWT YALPLDSPRL LAPRVLEVDS QSLVSCTLDG
260 270 280 290 300
LFPASEAGVH LALGDKRLNP EVTLEGDAIV ATATATAEEE GIKQLVCAVT
310 320 330 340 350
LGGERRESRE NVTVYSFPAP LLTLSEPSAP EGKLVTVTCT AGARALVTLE
360 370 380 390 400
GVPAAAPGQP AQLQFNASES DDGRSFFCDA TLELDGETLS KNGSAELRVL
410 420 430 440 450
YAPRLDDADC PRSWTWPEGP EQTLRCEARG NPTPAVHCAR SDGGAVLALG
460 470 480 490 500
LLGPVTRALA GTYRCTAANV QGEAVKDVTL TVEYAPALDS VGCPERVTWL
510 520 530 540 550
EGTEASLSCV AHGVPPPSVS CVRFRQADVI EGLLLVAREH AGTYRCEAIN
560 570 580 590 600
ARALAKNVAV TVEYGPSFEE RSCPSNWTWV EGSEQLFSCE VEGKPQPSVQ
610 620 630 640 650
CVGSEGASEG LLLPLAPLNP SPSDPSVPRD LAPGIYVCNA TNPLGSAVKT
660 670 680 690 700
VVVSAESPPQ MDDSTCPSDQ TWLEGAEAAG PACARGRPSP RVRCSREGAP
710 720 730 740 750
RPARPRVSRE DAGTYLCVAT NAHGSDSRTV TVGVEYRPVV AELAASPSGG
760 770 780 790 800
VRPGGNFTLT CRAEAWPPAQ ISWRAPPGAP NIGLSSNNST LSVPGAMGSH
810 820 830 840 850
GGEYECEATN AHGHARRITV RVAGPWLWIA VGGAVGGAVL LAAGAGLAFY
860 870 880 890 900
VQSTACKKGE YNVQEAESSG EAVCLNGAGG GAGSGAEGGP EAEDSAESPA
910
GGEVFAIQLT SA
Length:912
Mass (Da):95,683
Last modified:November 1, 1996 - v1
Checksum:i4DC032853DA0EAE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13199 Unassigned DNA. Translation: AAA18478.1.
RefSeqiNP_001164621.1. NM_001171150.1.
UniGeneiOcu.7551.

Genome annotation databases

GeneIDi100328960.
KEGGiocu:100328960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13199 Unassigned DNA. Translation: AAA18478.1.
RefSeqiNP_001164621.1. NM_001171150.1.
UniGeneiOcu.7551.

3D structure databases

ProteinModelPortaliQ28730.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100328960.
KEGGiocu:100328960.

Organism-specific databases

CTDi7087.

Phylogenomic databases

HOVERGENiHBG052077.
InParanoidiQ28730.
KOiK06769.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 9 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression."
    Yoshihara Y., Oka S., Nemoto Y., Watanabe Y., Nagata S., Kagamiyama H., Mori K.
    Neuron 12:541-553(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Japanese white.
    Tissue: Brain.

Entry informationi

Entry nameiICAM5_RABIT
AccessioniPrimary (citable) accession number: Q28730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.