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Reviewed, UniProtKB/Swiss-Prot Q28719 (PTGR1_RABIT)

Last modified November 25, 2008. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Prostaglandin reductase 1
      Short name=PRG-1
    EC=1.3.1.-
Alternative name(s):
    NADP-dependent leukotriene B4 12-hydroxydehydrogenase
    EC=1.3.1.74
    15-oxoprostaglandin 13-reductase
    EC=1.3.1.48
    ADRAB-F
Gene names
Name: PTGR1
Synonyms: LTB4DH
OrganismOryctolagus cuniculus (Rabbit)
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

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Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 By similarity.

Catalytic activity

n-alkanal + NAD(P)(+) = alk-2-enal + NAD(P)H.

11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.

Subunit structure

Monomer or homodimer By similarity.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

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Ontologies

Keywords

   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function15-oxoprostaglandin 13-oxidase activity

Inferred from electronic annotation. Source: EC

2-alkenal reductase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Prostaglandin reductase 1
PRO_0000218068

Regions

Nucleotide binding149 – 16618NADP Potential

Sites

Binding site1781NADP By similarity
Binding site1931NADP By similarity
Binding site2171NADP By similarity
Binding site2451NADP By similarity
Binding site3211NADP By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q28719-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 0CABB6EEB027EC16

FASTA34938,219
        10         20         30         40         50         60 
MVRAKNWTLK KHFHGHPTDS DFELKTVELP PLNNGEVLLE ALFLSVDPYM RLGSKRLKEG 

        70         80         90        100        110        120 
DTMMGQQVAR VVESKNPAWP VGTLVLAHSG WASHSISDGQ QLEKLLTEWP DTLPLSLALG 

       130        140        150        160        170        180 
TVGMPGITAY FGLLEICGAK SGDTVLVNAA AGAVGAVVGQ IAKIKGCRVV GAAGSEEKVD 

       190        200        210        220        230        240 
YLKKIGFDFA FNYKTVKSLE ETLKKAAPDG YDCYFDNVGG EFSNTVIRQM KKFGRVAICG 

       250        260        270        280        290        300 
AISMYNSTGQ LPPGPSPESV LYQEIRMEGF IFNRWKGEVG QKALKELLTW VLEGKIQYRE 

       310        320        330        340 
FVIEGFENMP AAFMRMLKGE NVGKARSESL KSGTCKPGDH PHDLIFPIT

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References

[1]"'Adults only' mRNAs: differential cloning to search for proteins present in intestine of adult but not baby rabbits."
Boll W., Mantei N.
Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
Tissue: Small intestine.

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Cross-references

Sequence databases

Z34285 mRNA. Translation: CAA84039.1.
PIRS47093.
RefSeqNP_001076171.1.
UniGeneOcu.2102

3D structure databases

SMRQ28719. Positions 1-325.
ModBaseSearch...

Genome annotation databases

EnsemblENSOCUG00000004879. Oryctolagus cuniculus. [Contig view]
GeneID100009440.

Phylogenomic databases

HOVERGENQ28719.

Family and domain databases

InterProIPR002085. AlcDHase_SF_Zn.
IPR013149. AlcDHase_Zn-bd.
IPR014190. B4_12hDHase.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR02825. B4_12hDH. 1 hit.
ProtoNetSearch...

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Entry information

Entry namePTGR1_RABIT
AccessionPrimary (citable) accession number: Q28719
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 25, 2008
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents