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Protein

Cyclic nucleotide-gated olfactory channel

Gene

CNGA2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei521 – 5211cAMPSequence analysis
Binding sitei536 – 5361cAMPSequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi462 – 584123cAMPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Olfaction, Sensory transduction, Transport

Keywords - Ligandi

Calmodulin-binding, cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated olfactory channel
Alternative name(s):
Aorta CNG channel
Short name:
RACNG
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2
Short name:
CNG channel alpha-2
Short name:
CNG-2
Short name:
CNG2
Gene namesi
Name:CNGA2
Synonyms:CNCG2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 140140CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16020Helical; Name=H1Sequence analysisAdd
BLAST
Topological domaini161 – 17313ExtracellularSequence analysisAdd
BLAST
Transmembranei174 – 19219Helical; Name=H2Sequence analysisAdd
BLAST
Topological domaini193 – 21624CytoplasmicSequence analysisAdd
BLAST
Transmembranei217 – 23620Helical; Name=H3Sequence analysisAdd
BLAST
Topological domaini237 – 27438ExtracellularSequence analysisAdd
BLAST
Transmembranei275 – 29723Helical; Name=H4Sequence analysisAdd
BLAST
Topological domaini298 – 34952CytoplasmicSequence analysisAdd
BLAST
Transmembranei350 – 36920Helical; Name=H5Sequence analysisAdd
BLAST
Topological domaini370 – 45384ExtracellularSequence analysisAdd
BLAST
Transmembranei454 – 47421Helical; Name=H6Sequence analysisAdd
BLAST
Topological domaini475 – 664190CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Cyclic nucleotide-gated olfactory channelPRO_0000219314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008136.

Structurei

3D structure databases

ProteinModelPortaliQ28718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili597 – 64044By similarityAdd
BLAST

Domaini

The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ28718.
KOiK04949.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEKSNGVKS SPANNHNNHV PATIKANGKD ESRTRSRPQS AADDDTSSEL
60 70 80 90 100
QRLAEMDAPQ QRRGGFRRIV RLVGVIRQWA NRNFREEEAR PDSFLERFRG
110 120 130 140 150
PELQTVTTQQ GDGKGDKDGD GKGTKKKFEL FVLDPAGDWY YRWLFVIAMP
160 170 180 190 200
VLYNWCLLVA RACFSDLQRG YFLVWLVLDY FSDVVYIADL FIRLRTGFLE
210 220 230 240 250
QGLLVKDPKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVGI HNPELRFNRL
260 270 280 290 300
LHFARMFEFF DRTETRTSYP NIFRISNLVL YILVIIHWNA CIYYAISKSI
310 320 330 340 350
GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY
360 370 380 390 400
LFVIFDFLIG VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK
410 420 430 440 450
VSKEMEAKVI KWFDYLWTNK KTVDEREVLK NLPAKLRAEI AINVHLSTLK
460 470 480 490 500
KVRIFQDCEA GLLVELVLKL RPQVFSPGDY ICRKGDIGKE MYIIKEGKLA
510 520 530 540 550
VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI RSLGYSDLFC
560 570 580 590 600
LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA ASMEVDVQEK
610 620 630 640 650
LKQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLEVKM KQNTEDDYLS
660
DGMNSPEPAA AEQP
Length:664
Mass (Da):76,206
Last modified:November 1, 1997 - v1
Checksum:i5E9170D0B322B3E9
GO

Sequence cautioni

The sequence CAA42201 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59668 mRNA. Translation: CAA42201.1. Different initiation.
PIRiS35691.
RefSeqiNP_001075863.1. NM_001082394.1.
UniGeneiOcu.3283.

Genome annotation databases

GeneIDi100009269.
KEGGiocu:100009269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59668 mRNA. Translation: CAA42201.1. Different initiation.
PIRiS35691.
RefSeqiNP_001075863.1. NM_001082394.1.
UniGeneiOcu.3283.

3D structure databases

ProteinModelPortaliQ28718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009269.
KEGGiocu:100009269.

Organism-specific databases

CTDi1260.

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ28718.
KOiK04949.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNGA2_RABIT
AccessioniPrimary (citable) accession number: Q28718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 11, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.