Reviewed, UniProtKB/Swiss-Prot Q28690 (EI2BB_RABIT)

Names and origin

Protein names

Recommended name:
    Translation initiation factor eIF-2B subunit beta
Alternative name(s):
    eIF-2B GDP-GTP exchange factor subunit beta

Gene names

Name:	EIF2B2
Synonyms:	EIF2BB

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subunit structure	Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
Sequence similarities	Belongs to the EIF-2B alpha/beta/delta subunits family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cellular response to stimulus Inferred from sequence or structural similarity. Source: UniProtKB myelination Inferred from sequence or structural similarity. Source: UniProtKB oligodendrocyte development Inferred from sequence or structural similarity. Source: UniProtKB ovarian follicle development Inferred from sequence or structural similarity. Source: UniProtKB translational initiation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	eukaryotic translation initiation factor 2B complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB GTP binding Inferred from sequence or structural similarity. Source: UniProtKB protein binding Inferred from sequence or structural similarity. Source: UniProtKB translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EIF2S2	P20042	1	EBI-1226292,EBI-711977	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Translation initiation factor eIF-2B subunit beta		PRO_0000156063

Sequences

	Sequence		Length	Mass (Da)
	Q28690-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 05517460A3D79369	FASTA	351	39,004
	10 20 30 40 50 60 MPGATEKGSE LSERIESFVE ALKRGGGQRS SEDMARETLG LLRRIITDHR WSNAGELMEL 70 80 90 100 110 120 IRREGRRMMA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS DESDQQESLH KLLTSGGLSE 130 140 150 160 170 180 DFSFHYAQLQ SNIVEAINEL LVELEGTTEN IAAQALEHIH SNEVIMTIGL SRTVEAFLRE 190 200 210 220 230 240 AARKRKFHVI VAECAPFCQG HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL 250 260 270 280 290 300 ANGALRAVTG THTLALAAKH HSTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG 310 320 330 340 350 DILDKVGCHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPEDHV L

References

[1]

"Cloning and expression of cDNAs for the beta subunit of eukaryotic initiation factor-2B, the guanine nucleotide exchange factor for eukaryotic initiation factor-2." Craddock B.L., Price N.T., Proud C.G. Biochem. J. 309:1009-1014(1995) [PubMed: 7639677] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: New Zealand white. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z48222 mRNA. Translation: CAA88255.1.
PIR	S56172.
RefSeq	NP_001076100.1.
UniGene	Ocu.2109
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q28690. 2 interactions.
Genome annotation databases
GeneID	100009318.
Organism-specific databases
CTD	100009318.
Phylogenomic databases
HOVERGEN	Q28690.
Family and domain databases
InterPro	IPR000649. IF-2B_related. [Graphical view]
PANTHER	PTHR10233. IF-2B_related. 1 hit.
Pfam	PF01008. IF-2B. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EI2BB_RABIT

Accession

Primary (citable) accession number: Q28690

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	September 1, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)