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Protein

Canalicular multispecific organic anion transporter 1

Gene

ABCC2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates hepatobiliary excretion of numerous organic anions.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi669 – 676ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1332 – 1339ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Canalicular multidrug resistance protein
Epithelial basolateral chloride conductance regulator
Multidrug resistance-associated protein 2
Gene namesi
Name:ABCC2
Synonyms:EBCR, MRP2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularBy similarityAdd BLAST27
Transmembranei28 – 48Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini49 – 68CytoplasmicBy similarityAdd BLAST20
Transmembranei69 – 89Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini90 – 93ExtracellularBy similarity4
Transmembranei94 – 114Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini115 – 126CytoplasmicBy similarityAdd BLAST12
Transmembranei127 – 147Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini148 – 165ExtracellularBy similarityAdd BLAST18
Transmembranei166 – 186Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini187 – 311CytoplasmicBy similarityAdd BLAST125
Transmembranei312 – 332Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini333 – 358ExtracellularBy similarityAdd BLAST26
Transmembranei359 – 379Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini380 – 435CytoplasmicBy similarityAdd BLAST56
Transmembranei436 – 456Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini457 – 459ExtracellularBy similarity3
Transmembranei460 – 480Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini481 – 542CytoplasmicBy similarityAdd BLAST62
Transmembranei543 – 563Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini564 – 585ExtracellularBy similarityAdd BLAST22
Transmembranei586 – 606Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini607 – 969CytoplasmicBy similarityAdd BLAST363
Transmembranei970 – 990Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini991 – 1031ExtracellularBy similarityAdd BLAST41
Transmembranei1032 – 1052Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1053 – 1095CytoplasmicBy similarityAdd BLAST43
Transmembranei1096 – 1116Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1117ExtracellularBy similarity1
Transmembranei1118 – 1138Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1139 – 1209CytoplasmicBy similarityAdd BLAST71
Transmembranei1210 – 1230Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1231 – 1232ExtracellularBy similarity2
Transmembranei1233 – 1253Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1254 – 1543CytoplasmicBy similarityAdd BLAST290

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933581 – 1564Canalicular multispecific organic anion transporter 1Add BLAST1564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei279PhosphoserineBy similarity1
Modified residuei281PhosphoserineBy similarity1
Modified residuei876PhosphoserineBy similarity1
Modified residuei925PhosphoserineBy similarity1
Modified residuei929PhosphoserineBy similarity1
Glycosylationi1009N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1436PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ28689.

Expressioni

Tissue specificityi

Expressed in liver, kidney and small intestine.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007069.

Structurei

3D structure databases

ProteinModelPortaliQ28689.
SMRiQ28689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini320 – 603ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini635 – 859ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini977 – 1262ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST286
Domaini1298 – 1532ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ28689.

Family and domain databases

Gene3Di1.20.1560.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030247. ABCC2.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
PANTHERiPTHR24223:SF176. PTHR24223:SF176. 1 hit.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q28689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDKFCNSTF WNSSLLDSPE ADLPLCFEQT VLVWIPLIFL WLLAPWQLFH
60 70 80 90 100
VYRSRTKRSP ITKFYLAKQV LVGCLLILAV IELILVLTEN SGQATIPAVR
110 120 130 140 150
YTNPILYLVT WLLVLLIQHS RQSCVQKNSW FLSLFWILSI LCGTFQFQTL
160 170 180 190 200
IRTLLRDSNS NLAYSCLFFI SYGFQILILI LSAFSEKDNS SKNPSVTASF
210 220 230 240 250
LSKISFSWYD SVVLKGYKRP LTLEDVWDID EEFKAKTIVS RFEVHMAKEL
260 270 280 290 300
KKARKAFQKR QQKKSQKNSR LQGLNKNQSQ SQDVLVLEET KKKNKKSGTT
310 320 330 340 350
KDFPKSWLVK TIFKTFYMVL LKSFLLKLVY DLLTFLNPQL LKLLITFVSD
360 370 380 390 400
PNSYAWLGYI FAILLFAVAL IQSICLQTYF HMCFNLGMCV GTTVMATVYK
410 420 430 440 450
KALTISNLAK RQYTIGETVN LMSVDAQKLM DVTNFIHLVW SSVLQIVLSI
460 470 480 490 500
YFLWVELGPS VLAGVGVMVL LIPVNGILAT KNRNIQFKNM KYKDKRLRIM
510 520 530 540 550
NEILSGMKIL KYFAWEPSFK DQVHNLRKKE LKNLRTFAYM QSVVMFLLYL
560 570 580 590 600
TPVLVSVTTF SVYVLVDSNN ILDAEKAFTS ITLFNILRFP MSMLPNVISA
610 620 630 640 650
MLQASVSVDR LEKYLSGDDL DTSAIQRDPN FDKAVQFSEA SFTWDRNLEP
660 670 680 690 700
TIRNVNLDIM PGQLVAVVGT VGSGKSSLMS AMLGEMENVH GHITIKGTTA
710 720 730 740 750
YVPQQSWIQN GTIKDNILFG AEFDERRYQR VLEACALLPD LEILPGGDLA
760 770 780 790 800
EIGEKGINLS GGQKQRISLA RASYQNSDIY ILDDPLSAVD AHVGKHIFNK
810 820 830 840 850
VLGPNGLLNG KTRLLVTHSL HFLPQVDEIV VVENGTILEK GSYSSLLAKK
860 870 880 890 900
GVFAKNLKMF VKHTDSEGEV TVNDGSEEDD DDDSGLISSI EEFPEDSISL
910 920 930 940 950
TLKRENSLHR TLSRSSRSSG RRLKSLKNSL KAQNGKTPKE EEVVKGQKLI
960 970 980 990 1000
KKEFMETGKV KFSIYLKYLQ AIGWCSIVGI IFAYVLNSVA FIGSNLWLSA
1010 1020 1030 1040 1050
WTSDSNTYNG TNYPASQRDL RIGIFGVLGL AQGLTVLVAS FWSASGCAHA
1060 1070 1080 1090 1100
SNILHKQLLN NILRAPMSFF NTTPIGRIVN RFAGDISTVD DTLPQSLRSW
1110 1120 1130 1140 1150
MMCFLAIIST LIMICMATPV FAVIIIPLAI IYVAVQVFYV ATSRQLRRLD
1160 1170 1180 1190 1200
SVTRSPIYSH FTETVSGLPV IRAFEHQQRF LKQNEIGIDT NQKCVSSWIT
1210 1220 1230 1240 1250
SNRWLAFRLE LVGNLVVFSS ALMMVIYRDT LSGDVVGFVL SNALNITQTL
1260 1270 1280 1290 1300
NWLVRMTSET ETNIVAVERI TEYIKVENEA PWVTDKRPPA GWPHKGEIQF
1310 1320 1330 1340 1350
SNYQVRYRPE LDLVLKGINC DIKSMEKIGV VGRTGAGKSS LTNCLFRILE
1360 1370 1380 1390 1400
AAGGHITIDG IDIASIGLHD LRGKLTIIPQ DPVLFSGSLR MNLDPFNNYS
1410 1420 1430 1440 1450
DEEIWRALEL AHLKSFVAGL QHGLSREVSE AEDNLSIGQR QLLCLGRALL
1460 1470 1480 1490 1500
RKSKILVLDE ATAAVDLETD HLIQTTIRNE FSHCTVITIA HRLHTIMDSD
1510 1520 1530 1540 1550
KIMVLDNGNI VEYGSPEELL ESAGPFSLMA KESGIENVNN TAFWAAAARD
1560
AGAGRLSPGF ASVT
Length:1,564
Mass (Da):175,544
Last modified:November 1, 1996 - v1
Checksum:iD8FBF5AC8FE45873
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49144 Genomic DNA. Translation: CAA89004.1.

Similar proteinsi

Entry informationi

Entry nameiMRP2_RABIT
AccessioniPrimary (citable) accession number: Q28689
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families