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Protein

Complement component C8 gamma chain

Gene

C8G

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Keywords - Ligandi

Retinol-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C8 gamma chain
Gene namesi
Name:C8G
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane attack complex, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 202179Complement component C8 gamma chainPRO_0000017883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 – 60Interchain (with C-194 in C8-alpha chain)By similarity
Disulfide bondi96 ↔ 188By similarity
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ28679.
SMRiQ28679. Positions 31-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005369.
InParanoidiQ28679.
KOiK03999.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR002968. A1-microglobln.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01215. A1MCGLOBULIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28679-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLRGRAVLL AVLLAAGSLG RWAQKPRGAP SAISAIQPKA NFDAQQFAGT
60 70 80 90 100
WLLAAVGSAC HFLQEQGHRA EATALHVAPQ GAAMAVSTFR KLDGICWQVS
110 120 130 140 150
QRYGATGVPG RFLLPARGPR GAVHVVAAET DYHSFAVLYL ERARQLSVKL
160 170 180 190 200
YVRSLPVSDS VLGAFEQRVA QANLTQDQVL FFPTYGFCEA ADQFHILDEV

RR
Length:202
Mass (Da):21,901
Last modified:November 1, 1996 - v1
Checksum:iE6E82B677E126A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26979 mRNA. Translation: AAA31193.1.
PIRiI46688.
RefSeqiNP_001075723.1. NM_001082254.1.
UniGeneiOcu.1992.

Genome annotation databases

GeneIDi100009075.
KEGGiocu:100009075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26979 mRNA. Translation: AAA31193.1.
PIRiI46688.
RefSeqiNP_001075723.1. NM_001082254.1.
UniGeneiOcu.1992.

3D structure databases

ProteinModelPortaliQ28679.
SMRiQ28679. Positions 31-202.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009075.
KEGGiocu:100009075.

Organism-specific databases

CTDi733.

Phylogenomic databases

HOVERGENiHBG005369.
InParanoidiQ28679.
KOiK03999.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR002968. A1-microglobln.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01215. A1MCGLOBULIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of rabbit complement component C8. Functional evidence for the species-selective recognition of C8 alpha by homologous restriction factor (CD59)."
    White R.V., Kaufman K.M., Letson C.S., Platteborze P.L., Sodetz J.M.
    J. Immunol. 152:2501-2508(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiCO8G_RABIT
AccessioniPrimary (citable) accession number: Q28679
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: October 14, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.