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Protein
Submitted name:

Renal Na/Ca exchanger NACA-2

Gene

NCX1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Renal Na/Ca exchanger NACA-2Imported
Gene namesi
Name:NCX1Imported
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2520HelicalSequence analysisAdd
BLAST
Transmembranei75 – 9319HelicalSequence analysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence analysisAdd
BLAST
Transmembranei200 – 22324HelicalSequence analysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence analysisAdd
BLAST
Transmembranei766 – 79025HelicalSequence analysisAdd
BLAST
Transmembranei843 – 86321HelicalSequence analysisAdd
BLAST
Transmembranei875 – 89521HelicalSequence analysisAdd
BLAST
Transmembranei911 – 92919HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000009337.

Structurei

3D structure databases

ProteinModelPortaliQ28662.
SMRiQ28662. Positions 403-695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini302 – 36564JInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.
HOGENOMiHOG000266971.
HOVERGENiHBG006441.
KOiK05849.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR001623. DnaJ_domain.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR002987. NaCa_exhngr1.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
PR01260. NACAEXCHNGR1.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRFSLSPPF SMGFHLLAIV ALFFFRVDHV SAETEMEGEG NETGECTGSY
60 70 80 90 100
YCKKGVILPI WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI
110 120 130 140 150
EVITSQEKEI TIKKPNGETT KTTVRIWNET VSNLTLMALG SSAPEILLSV
160 170 180 190 200
IEVCGHNFTA GDLGPSTIVG SAAFNMFIII ALCVYVVPDG ETRKIKHLRV
210 220 230 240 250
FFVTAAWSIF AYTWLYIILS VISPGIVEVW EGLLTFFFFP ICVVFAWVAD
260 270 280 290 300
RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP SSKTEIEMDG KVVNSHVDNF
310 320 330 340 350
LDGALVLDVD ERDQDDEEAR REMARILKEL KQKHPEKEIE QLIELANYQV
360 370 380 390 400
LSQQQKSRAF YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNTEMAEN
410 420 430 440 450
DPVSKIFFEQ GTYQCLENCG TVALTIIRRG GDLTNTVFVD FRTEDGTANA
460 470 480 490 500
GSDYEFTEGT VVFKPGETQK EIRVGIIDDD IFEEDENFLV HLSNVKVSSE
510 520 530 540 550
TSEDGILEAN HISTLACLGS PCTATVTIFD DDHAGIFTFE ESVTHVSESI
560 570 580 590 600
GIMEVKVLRT SGARGNVIVP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV
610 620 630 640 650
KIITIRIFDR EEYEKECSLS LVLEEPKWIR RGMKALLLNE LGGFTITEEY
660 670 680 690 700
DDKQPLTSKE EEERRIAEMG RPILGEHTKL EVIIEESYEF KSTVDKLIKK
710 720 730 740 750
TNLALVVGTN SWREQFIEAI TVSAGEDDDD DECGEEKLPS CFDYVMHFLT
760 770 780 790 800
VFWKVLFAFV PPTEYWNGWA CFIVSILMIG LLTAFIGDLA SHFGCTIGLK
810 820 830 840 850
DSVTAVVFVA LGTSVPDTFA SKVAATQDQY ADASIGNVTG SNAVNVFLGI
860 870 880 890 900
GVAWSIAAIY HAANGEHFKV SPGTLAFSVT LFTIFAFINV GVLLYRRRPE
910 920 930 940
IGGELGGPRT AKLLTSCLFV LLWLLYIFFS SLEAYCHIKG F
Length:941
Mass (Da):105,129
Last modified:November 1, 1996 - v1
Checksum:i7E11396DE70A4084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52665 mRNA. Translation: AAA97928.1.
RefSeqiNP_001164429.1. NM_001170958.1.
UniGeneiOcu.2062.

Genome annotation databases

GeneIDi100328570.
KEGGiocu:100328570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52665 mRNA. Translation: AAA97928.1.
RefSeqiNP_001164429.1. NM_001170958.1.
UniGeneiOcu.2062.

3D structure databases

ProteinModelPortaliQ28662.
SMRiQ28662. Positions 403-695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000009337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100328570.
KEGGiocu:100328570.

Organism-specific databases

CTDi6546.

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.
HOGENOMiHOG000266971.
HOVERGENiHBG006441.
KOiK05849.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR001623. DnaJ_domain.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR002987. NaCa_exhngr1.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
PR01260. NACAEXCHNGR1.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ28662_RABIT
AccessioniPrimary (citable) accession number: Q28662
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.