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Protein
Submitted name:

Renal Na/Ca exchanger NACA-2

Gene

NCX1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransportSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Renal Na/Ca exchanger NACA-2Imported
Gene namesi
Name:NCX1Imported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei75 – 93HelicalSequence analysisAdd BLAST19
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei200 – 223HelicalSequence analysisAdd BLAST24
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei766 – 790HelicalSequence analysisAdd BLAST25
Transmembranei843 – 863HelicalSequence analysisAdd BLAST21
Transmembranei875 – 895HelicalSequence analysisAdd BLAST21
Transmembranei911 – 929HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ28662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 365JInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1306 Eukaryota
ENOG410XPJP LUCA
HOGENOMiHOG000266971
HOVERGENiHBG006441
KOiK05849

Family and domain databases

Gene3Di2.60.40.2030, 2 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR001623 DnaJ_domain
IPR004836 Na_Ca_Ex
IPR032452 Na_Ca_Ex_C-exten
IPR002987 NaCa_exhngr1
IPR004837 NaCa_Exmemb
PfamiView protein in Pfam
PF03160 Calx-beta, 2 hits
PF01699 Na_Ca_ex, 2 hits
PF16494 Na_Ca_ex_C, 1 hit
PRINTSiPR01259 NACAEXCHNGR
PR01260 NACAEXCHNGR1
SMARTiView protein in SMART
SM00237 Calx_beta, 2 hits
SUPFAMiSSF141072 SSF141072, 2 hits
TIGRFAMsiTIGR00845 caca, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q28662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRFSLSPPF SMGFHLLAIV ALFFFRVDHV SAETEMEGEG NETGECTGSY
60 70 80 90 100
YCKKGVILPI WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI
110 120 130 140 150
EVITSQEKEI TIKKPNGETT KTTVRIWNET VSNLTLMALG SSAPEILLSV
160 170 180 190 200
IEVCGHNFTA GDLGPSTIVG SAAFNMFIII ALCVYVVPDG ETRKIKHLRV
210 220 230 240 250
FFVTAAWSIF AYTWLYIILS VISPGIVEVW EGLLTFFFFP ICVVFAWVAD
260 270 280 290 300
RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP SSKTEIEMDG KVVNSHVDNF
310 320 330 340 350
LDGALVLDVD ERDQDDEEAR REMARILKEL KQKHPEKEIE QLIELANYQV
360 370 380 390 400
LSQQQKSRAF YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNTEMAEN
410 420 430 440 450
DPVSKIFFEQ GTYQCLENCG TVALTIIRRG GDLTNTVFVD FRTEDGTANA
460 470 480 490 500
GSDYEFTEGT VVFKPGETQK EIRVGIIDDD IFEEDENFLV HLSNVKVSSE
510 520 530 540 550
TSEDGILEAN HISTLACLGS PCTATVTIFD DDHAGIFTFE ESVTHVSESI
560 570 580 590 600
GIMEVKVLRT SGARGNVIVP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV
610 620 630 640 650
KIITIRIFDR EEYEKECSLS LVLEEPKWIR RGMKALLLNE LGGFTITEEY
660 670 680 690 700
DDKQPLTSKE EEERRIAEMG RPILGEHTKL EVIIEESYEF KSTVDKLIKK
710 720 730 740 750
TNLALVVGTN SWREQFIEAI TVSAGEDDDD DECGEEKLPS CFDYVMHFLT
760 770 780 790 800
VFWKVLFAFV PPTEYWNGWA CFIVSILMIG LLTAFIGDLA SHFGCTIGLK
810 820 830 840 850
DSVTAVVFVA LGTSVPDTFA SKVAATQDQY ADASIGNVTG SNAVNVFLGI
860 870 880 890 900
GVAWSIAAIY HAANGEHFKV SPGTLAFSVT LFTIFAFINV GVLLYRRRPE
910 920 930 940
IGGELGGPRT AKLLTSCLFV LLWLLYIFFS SLEAYCHIKG F
Length:941
Mass (Da):105,129
Last modified:November 1, 1996 - v1
Checksum:i7E11396DE70A4084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52665 mRNA Translation: AAA97928.1
RefSeqiNP_001164429.1, NM_001170958.1
UniGeneiOcu.2062

Genome annotation databases

GeneIDi100328570
KEGGiocu:100328570

Similar proteinsi

Entry informationi

Entry nameiQ28662_RABIT
AccessioniPrimary (citable) accession number: Q28662
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health