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Protein

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

Gene

PPP2R5C

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Alternative name(s):
PP2A B subunit isoform B'-beta
PP2A B subunit isoform B'-gamma
PP2A B subunit isoform B56-gamma
PP2A B subunit isoform PR61-gamma
PP2A B subunit isoform R5-gamma
Gene namesi
Name:PPP2R5C
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformPRO_0000071459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ28651.

Expressioni

Tissue specificityi

Highly expressed in testis, heart and spleen. Also found in brain and skeletal muscle.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity). Interacts with SGO1; the interaction is direct. May interact with TP53 (By similarity). Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023817.

Structurei

3D structure databases

ProteinModelPortaliQ28651.
SMRiQ28651. Positions 30-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi472 – 48918Nuclear localization signalSequence analysisAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2085. Eukaryota.
ENOG410XQJW. LUCA.
HOGENOMiHOG000067326.
HOVERGENiHBG000009.
InParanoidiQ28651.
KOiK11584.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR002554. PP2A_B56.
[Graphical view]
PANTHERiPTHR10257. PTHR10257. 2 hits.
PfamiPF01603. B56. 1 hit.
[Graphical view]
PIRSFiPIRSF028043. PP2A_B56. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Gamma-3 (identifier: Q28651-1) [UniParc]FASTAAdd to basket
Also known as: Beta-3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTCNKAGSR MVVDAASSNG PFQPVALLHI RDVPPADQEK LFIQKLRQCC
60 70 80 90 100
VLFDFVSDPL SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA
110 120 130 140 150
VNMFRTLPPS SNPTGAEFDP EEDEPTLEAA WPHLQLVYEF FLRFLESPDF
160 170 180 190 200
QPNIAKKYID QKFVLQLLEL FDSEDPRERD FLKTTLHRIY GKFLGLRAYI
210 220 230 240 250
RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK EEHKIFLLKV
260 270 280 290 300
LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK
310 320 330 340 350
EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW
360 370 380 390 400
NNEYIMSLIS DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM
410 420 430 440 450
NQKLFDDCTQ QFKAEKLKEK LKMKEREEAW VKIENLAKAN PQYSLCSHAS
460 470 480 490 500
TVSMPLAMET DGPLFEDVQM LRKTVSDEAR QAQKDPKKER PLARRKSELP
510 520
QDPHTKKALE AHCRADELVP QDGR
Length:524
Mass (Da):60,985
Last modified:November 1, 1996 - v1
Checksum:iDC4520D122DAF386
GO
Isoform Gamma-1 (identifier: Q28651-2) [UniParc]FASTAAdd to basket
Also known as: Beta-4

The sequence of this isoform differs from the canonical sequence as follows:
     443-524: YSLCSHASTV...ADELVPQDGR → VLKKRAI

Show »
Length:449
Mass (Da):52,540
Checksum:iA86605BE052693DE
GO
Isoform Gamma-4 (identifier: Q28651-3) [UniParc]FASTAAdd to basket
Also known as: Beta-1

The sequence of this isoform differs from the canonical sequence as follows:
     482-524: AQKDPKKERPLARRKSELPQDPHTKKALEAHCRADELVPQDGR → QLVGRKAVSSTQVRKV

Show »
Length:497
Mass (Da):57,796
Checksum:i1BCFEBE7BA35C95B
GO
Isoform Gamma-5 (identifier: Q28651-4) [UniParc]FASTAAdd to basket
Also known as: Beta-2

The sequence of this isoform differs from the canonical sequence as follows:
     482-524: AQKDPKKERPLARRKSELPQDPHTKKALEAHCRADELVPQDGR → VKVPG

Show »
Length:486
Mass (Da):56,539
Checksum:i3C2FA19FC57ABDB4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei443 – 52482YSLCS…PQDGR → VLKKRAI in isoform Gamma-1. 1 PublicationVSP_005116Add
BLAST
Alternative sequencei482 – 52443AQKDP…PQDGR → QLVGRKAVSSTQVRKV in isoform Gamma-4. 1 PublicationVSP_005114Add
BLAST
Alternative sequencei482 – 52443AQKDP…PQDGR → VKVPG in isoform Gamma-5. 1 PublicationVSP_005115Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38191 mRNA. Translation: AAC48530.1.
U37770 mRNA. Translation: AAC48528.1.
U38190 mRNA. Translation: AAC48529.1.
U38192 mRNA. Translation: AAC48531.1.
RefSeqiNP_001075833.1. NM_001082364.1. [Q28651-1]
UniGeneiOcu.2277.

Genome annotation databases

GeneIDi100009216.
KEGGiocu:100009216.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38191 mRNA. Translation: AAC48530.1.
U37770 mRNA. Translation: AAC48528.1.
U38190 mRNA. Translation: AAC48529.1.
U38192 mRNA. Translation: AAC48531.1.
RefSeqiNP_001075833.1. NM_001082364.1. [Q28651-1]
UniGeneiOcu.2277.

3D structure databases

ProteinModelPortaliQ28651.
SMRiQ28651. Positions 30-406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023817.

Proteomic databases

PRIDEiQ28651.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009216.
KEGGiocu:100009216.

Organism-specific databases

CTDi5527.

Phylogenomic databases

eggNOGiKOG2085. Eukaryota.
ENOG410XQJW. LUCA.
HOGENOMiHOG000067326.
HOVERGENiHBG000009.
InParanoidiQ28651.
KOiK11584.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR002554. PP2A_B56.
[Graphical view]
PANTHERiPTHR10257. PTHR10257. 2 hits.
PfamiPF01603. B56. 1 hit.
[Graphical view]
PIRSFiPIRSF028043. PP2A_B56. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei2A5G_RABIT
AccessioniPrimary (citable) accession number: Q28651
Secondary accession number(s): Q28648, Q28650, Q28652
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.