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Protein

Cadherin-16

Gene

CDH16

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-16
Alternative name(s):
Kidney-specific cadherin
Short name:
Ksp-cadherin
Gene namesi
Name:CDH16
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 786ExtracellularSequence analysisAdd BLAST768
Transmembranei787 – 807HelicalSequence analysisAdd BLAST21
Topological domaini808 – 829CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000381119 – 829Cadherin-16Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi517N-linked (GlcNAc...)Sequence analysis1
Glycosylationi602N-linked (GlcNAc...)Sequence analysis1
Glycosylationi709N-linked (GlcNAc...)Sequence analysis1
Glycosylationi722N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Kidney specific. Limited to the basolateral membranes of renal tubular epithelial cells.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000506.

Structurei

3D structure databases

ProteinModelPortaliQ28634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 126Cadherin 1PROSITE-ProRule annotationAdd BLAST102
Domaini131 – 235Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini242 – 336Cadherin 3PROSITE-ProRule annotationAdd BLAST95
Domaini341 – 449Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Domaini455 – 564Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini569 – 665Cadherin 6PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni666 – 786Ectodomain GAdd BLAST121

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiQ28634.
KOiK06810.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR030721. Cadherin-16.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PANTHERiPTHR24028:SF1. PTHR24028:SF1. 2 hits.
PfamiPF00028. Cadherin. 3 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPAWLWLLC FSVPQALVEV SPTTLHVEVP ENYGGNFPLY LTKLPWPHKE
60 70 80 90 100
AGGRVVLSGD SGVAAEGPFS VEAESGFLLV TRALDREEQA EYQIQVTLEA
110 120 130 140 150
EDGHVLWGPQ SVTVHVKDEN DQVPQFSQAL YSARLSQGTR PGVPFLFLEA
160 170 180 190 200
SDGDEPGTAN SDLRFHILSQ TPAQPSPDVF RLEPRLGALA LSPEGSAGFD
210 220 230 240 250
HALEGPYQLL VQVKDMGDQA SGHQATATVE ISIVESTWTP LEPVHLAENL
260 270 280 290 300
KVPYPHHLAQ VHWSGGDVHY RLESQPPGPF DVDTEGKLYV TGELDREAQE
310 320 330 340 350
QYVLQVQAQN SRGEDYAEPL ELHVVVTDEN DHAPVCPPRG PPVSVPELSP
360 370 380 390 400
PGTAVTTLSA EDADAPGSPN SHVVYRLLSP EPQEGPEGGA FQLDPTSGSV
410 420 430 440 450
SLGAAPLEAG QNMLLQVLAV DLAGAEAGLS STCEVAVTVT DVNDHAPEFT
460 470 480 490 500
SSQVGPVSLP EDTEPGTLVA TLTATDADLE PAFRLMDFTI EAGDGEGTFG
510 520 530 540 550
LDWEPDSGHV QLYLLKNLSY EAAPSHTVVV VVRNVVETVG PGPGPGATAT
560 570 580 590 600
VTVLVEKVMP PPRLEQKSYE ADIPVNAPAG SFLLTIQPAE PWNGALRFSL
610 620 630 640 650
VNDSEGWFCI QKVSGEVHTA RPLQGARPGD SYTVLVEAQD ADAPRLSTSA
660 670 680 690 700
ALVIHFLRAP PAPALPLAPM PSRHLCTPRQ DHGVLIPAPS EDPDMATGHG
710 720 730 740 750
PYSFALGPNP TVQRDWRLQP LNDSHAFLTL ALHWVEPREH IVPVVVSQDA
760 770 780 790 800
RVWQLPVRVV VCRCNTEGEC MRKVGRMKGM PTKLSAVGIL VGTLAAIGFF
810 820
LILIFTHLAL ARKKDLDAPA DNVPLKAAA
Length:829
Mass (Da):88,828
Last modified:November 1, 1996 - v1
Checksum:iD2DF10E6C47A43B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28945 mRNA. Translation: AAC48472.1.
PIRiI46536.
RefSeqiNP_001164517.1. NM_001171046.1.
UniGeneiOcu.2272.

Genome annotation databases

GeneIDi100328594.
KEGGiocu:100328594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28945 mRNA. Translation: AAC48472.1.
PIRiI46536.
RefSeqiNP_001164517.1. NM_001171046.1.
UniGeneiOcu.2272.

3D structure databases

ProteinModelPortaliQ28634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000506.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100328594.
KEGGiocu:100328594.

Organism-specific databases

CTDi1014.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiQ28634.
KOiK06810.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR030721. Cadherin-16.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PANTHERiPTHR24028:SF1. PTHR24028:SF1. 2 hits.
PfamiPF00028. Cadherin. 3 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD16_RABIT
AccessioniPrimary (citable) accession number: Q28634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.