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Protein

Prolactin

Gene

PRL

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Lactation

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:PRL
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Chaini29 – 227199ProlactinPRO_0000032924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 39By similarity
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity
Disulfide bondi86 ↔ 202By similarity
Modified residuei118 – 1181PhosphoserineBy similarity
Disulfide bondi219 ↔ 227By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001120.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AN3model-A40-227[»]
ProteinModelPortaliQ28632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiQ28632.
KOiK05439.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKWSRRTG SLLLLLVSNL LLCKSTASLP ICPSGAVNCQ VSLRDLFDRA
60 70 80 90 100
VILSHHIHKL SSEMFNEFDK RYTQGRGFIT KAINSCHTSS LSTPEDKEQA
110 120 130 140 150
QQIHHEDLLN MVLRVLPSWN DPLYHLVTEV RGMQEAPDAI LSKAIEIEEQ
160 170 180 190 200
NRRLLEGMEK IVGQVHPGIK ENEIYSVWSG LPSLQMADED ARLFAFYNLL
210 220
HCLRRDSHKI DNYLKLLKCR IIYDSNC
Length:227
Mass (Da):25,990
Last modified:November 1, 1997 - v1
Checksum:i74B7570F4F7DB048
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27199 mRNA. Translation: AAB17481.1.
RefSeqiNP_001076144.1. NM_001082675.1.
UniGeneiOcu.2119.

Genome annotation databases

GeneIDi100009394.
KEGGiocu:100009394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27199 mRNA. Translation: AAB17481.1.
RefSeqiNP_001076144.1. NM_001082675.1.
UniGeneiOcu.2119.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AN3model-A40-227[»]
ProteinModelPortaliQ28632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009394.
KEGGiocu:100009394.

Organism-specific databases

CTDi5617.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiQ28632.
KOiK05439.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRL_RABIT
AccessioniPrimary (citable) accession number: Q28632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 11, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.