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Protein

WAP four-disulfide core domain protein 2

Gene

WFDC2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Broad range protease inhibitor.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAspartic protease inhibitor, Protease inhibitor, Serine protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI17.004

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 2
Alternative name(s):
Epididymal protein BE-20
Major epididymis-specific protein E4
Gene namesi
Name:WFDC2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000004137329 – 123WAP four-disulfide core domain protein 2Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 63PROSITE-ProRule annotation
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi46 ↔ 67PROSITE-ProRule annotation
Disulfide bondi50 ↔ 62PROSITE-ProRule annotation
Disulfide bondi56 ↔ 71PROSITE-ProRule annotation
Disulfide bondi81 ↔ 109PROSITE-ProRule annotation
Disulfide bondi92 ↔ 113PROSITE-ProRule annotation
Disulfide bondi96 ↔ 108PROSITE-ProRule annotation
Disulfide bondi102 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ28631

Expressioni

Tissue specificityi

Epididymis.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008219

Structurei

3D structure databases

ProteinModelPortaliQ28631
SMRiQ28631
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 71WAP 1PROSITE-ProRule annotationAdd BLAST42
Domaini74 – 122WAP 2PROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J36N Eukaryota
ENOG41125F3 LUCA
HOGENOMiHOG000115819
HOVERGENiHBG018073
InParanoidiQ28631

Family and domain databases

Gene3Di4.10.75.10, 2 hits
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00095 WAP, 2 hits
PRINTSiPR00003 4DISULPHCORE
SMARTiView protein in SMART
SM00217 WAP, 2 hits
SUPFAMiSSF57256 SSF57256, 2 hits
PROSITEiView protein in PROSITE
PS51390 WAP, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASRLVPLG AVLLLGLLLL LELPPVTGTG ADKPGVCPQL SADLNCTQDC
60 70 80 90 100
RADQDCAENL KCCRAGCSAI CSIPNEKEGS CPSIDFPQLG ICQDLCQVDS
110 120
QCPGKMKCCL NGCGKVSCVT PNF
Length:123
Mass (Da):12,803
Last modified:August 29, 2001 - v2
Checksum:i99F9A649CCBB5B32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26725 mRNA Translation: AAA66525.2
RefSeqiNP_001075823.1, NM_001082354.1
UniGeneiOcu.2376

Genome annotation databases

GeneIDi100009206
KEGGiocu:100009206

Similar proteinsi

Entry informationi

Entry nameiWFDC2_RABIT
AccessioniPrimary (citable) accession number: Q28631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 29, 2001
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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