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Protein
Submitted name:

L-selectin

Gene

SELL

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.UniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. response to ATP Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesionUniRule annotation

Keywords - Ligandi

LectinImported

Names & Taxonomyi

Protein namesi
Submitted name:
L-selectinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:SELLImported
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838 PotentialImportedAdd
BLAST
Chaini39 – 376338L-selectinImportedPRO_5000144599Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000017151.

Structurei

3D structure databases

ProteinModelPortaliQ28629.
SMRiQ28629. Positions 39-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selectin/LECAM family.UniRule annotation
Contains C-type lectin domain.SAAS annotation

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalImported, SushiSAAS annotation

Phylogenomic databases

eggNOGiNOG258998.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
KOiK06495.
TreeFamiTF326910.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFPWKCQSP QRGLWNVFKL WVWATLCCDF LAYHGTNCWT YHYSEKPMNW
60 70 80 90 100
ERARKFCREN YTDLVAIQNK GEIEYLEKTL PFSRSYYWIG IRKIGNIWTW
110 120 130 140 150
VGTNKSLTAE AENWGEGEPN NKKTKEDCVE IYIKRLRDSG KWNDDSCQKR
160 170 180 190 200
KAALCYTASC HPGSCSGHGE CVEVINNYTC SCDVGYYGPQ CQFVMQCEPL
210 220 230 240 250
EAPELGTMAC THPLGEFSFS SQCGFSCLEG TNLTGIEETT CGPLGNWSSL
260 270 280 290 300
RPTCQVIQCE PLTAPDLGTI DCSHPRAVFG FTSTCTFSCS EGAELIGMKK
310 320 330 340 350
TVCGSSGIWS SPTPKCQKVD RSFSMIKEGD YNPLFIPVAV MVTAFSGLAF
360 370
IIWLARRLKK GKKSQKSKDD ILIHPL
Length:376
Mass (Da):42,346
Last modified:November 1, 1996 - v1
Checksum:i59F6AD530F490947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02000040 Genomic DNA. No translation available.
AAGW02000041 Genomic DNA. No translation available.
U26535 mRNA. Translation: AAA67896.1.
PIRiJC4892.
RefSeqiNP_001075821.1. NM_001082352.1.
UniGeneiOcu.2027.

Genome annotation databases

EnsembliENSOCUT00000029156; ENSOCUP00000017151; ENSOCUG00000017432.
GeneIDi100009204.
KEGGiocu:100009204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02000040 Genomic DNA. No translation available.
AAGW02000041 Genomic DNA. No translation available.
U26535 mRNA. Translation: AAA67896.1.
PIRiJC4892.
RefSeqiNP_001075821.1. NM_001082352.1.
UniGeneiOcu.2027.

3D structure databases

ProteinModelPortaliQ28629.
SMRiQ28629. Positions 39-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000017151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000029156; ENSOCUP00000017151; ENSOCUG00000017432.
GeneIDi100009204.
KEGGiocu:100009204.

Organism-specific databases

CTDi6402.

Phylogenomic databases

eggNOGiNOG258998.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
KOiK06495.
TreeFamiTF326910.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA for rabbit L-selectin."
    Qian J., Marks R.M.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: KidneyImported.
  2. "Cloning of the cDNA for rabbit L-selectin and expression of recombinant protein with a kinase target site to facilitate radiolabeling."
    Qian J., Huang X., Marks R.M.
    Biochem. Biophys. Res. Commun. 225:406-412(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Genome Sequence of Oryctolagus cuniculus (European rabbit)."
    The Genome Sequencing Platform
    Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., Lindblad-Toh K.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ThorbeckeImported.
  4. "A high-resolution map of human evolutionary constraint using 29 mammals."
    Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.
    , Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.
    Nature 478:476-482(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ThorbeckeImported.
  5. Ensembl
    Submitted (AUG-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: ThorbeckeImported.

Entry informationi

Entry nameiQ28629_RABIT
AccessioniPrimary (citable) accession number: Q28629
Secondary accession number(s): G1TJM3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.