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Protein

L-selectin

Gene

SELL

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesionUniRule annotation
LigandCalciumUniRule annotation, LectinImported

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectinUniRule annotation
Gene namesi
Name:SELLImported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei334 – 355HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 155UniRule annotation
Disulfide bondi128 ↔ 147UniRule annotation
Disulfide bondi160 ↔ 171UniRule annotation
Disulfide bondi165 ↔ 180UniRule annotation
Disulfide bondi182 ↔ 191UniRule annotation
Disulfide bondi197 ↔ 241UniRule annotation
Disulfide bondi227 ↔ 254UniRule annotation
Disulfide bondi259 ↔ 303UniRule annotation
Disulfide bondi289 ↔ 316UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSOCUG00000017432

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000017151

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 156C-type lectinInterPro annotationAdd BLAST123
Domaini156 – 192EGF-likeInterPro annotationAdd BLAST37
Domaini195 – 256SushiInterPro annotationAdd BLAST62
Domaini257 – 318SushiInterPro annotationAdd BLAST62

Sequence similaritiesi

Belongs to the selectin/LECAM family.UniRule annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SushiPROSITE-ProRule annotationSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IS3T Eukaryota
ENOG410YB82 LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000236254
HOVERGENiHBG052375
KOiK06495
OMAiEAENWGD
OrthoDBiEOG091G09HU
TreeFamiTF326910

Family and domain databases

CDDicd00033 CCP, 2 hits
cd03592 CLECT_selectins_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR016348 L-selectin
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 2 hits
PIRSFiPIRSF002421 L-selectin, 1 hit
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 2 hits

Sequencei

Sequence statusi: Complete.

Q28629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFPWKCQSP QRGLWNVFKL WVWATLCCDF LAYHGTNCWT YHYSEKPMNW
60 70 80 90 100
ERARKFCREN YTDLVAIQNK GEIEYLEKTL PFSRSYYWIG IRKIGNIWTW
110 120 130 140 150
VGTNKSLTAE AENWGEGEPN NKKTKEDCVE IYIKRLRDSG KWNDDSCQKR
160 170 180 190 200
KAALCYTASC HPGSCSGHGE CVEVINNYTC SCDVGYYGPQ CQFVMQCEPL
210 220 230 240 250
EAPELGTMAC THPLGEFSFS SQCGFSCLEG TNLTGIEETT CGPLGNWSSL
260 270 280 290 300
RPTCQVIQCE PLTAPDLGTI DCSHPRAVFG FTSTCTFSCS EGAELIGMKK
310 320 330 340 350
TVCGSSGIWS SPTPKCQKVD RSFSMIKEGD YNPLFIPVAV MVTAFSGLAF
360 370
IIWLARRLKK GKKSQKSKDD ILIHPL
Length:376
Mass (Da):42,346
Last modified:November 1, 1996 - v1
Checksum:i59F6AD530F490947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02000040 Genomic DNA No translation available.
AAGW02000041 Genomic DNA No translation available.
U26535 mRNA Translation: AAA67896.1
PIRiJC4892
RefSeqiNP_001075821.1, NM_001082352.1
UniGeneiOcu.2027

Genome annotation databases

EnsembliENSOCUT00000029156; ENSOCUP00000017151; ENSOCUG00000017432
GeneIDi100009204
KEGGiocu:100009204

Similar proteinsi

Entry informationi

Entry nameiQ28629_RABIT
AccessioniPrimary (citable) accession number: Q28629
Secondary accession number(s): G1TJM3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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