Q28629 (Q28629_RABIT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: L-selectin PIRNR PIRNR002421
Organism	Oryctolagus cuniculus (Rabbit)
Taxonomic identifier	9986 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia By similarity. PIRNR PIRNR002421
Sequence similarities	Belongs to the selectin/LECAM family. PIRNR PIRNR002421 Contains 1 C-type lectin domain. SAAS SAAS001304

Ontologies

Keywords
Biological process	Cell adhesion PIRNR PIRNR002421
Domain	EGF-like domain SAAS SAAS000436 Repeat SAAS SAAS001304 Signal EMBL AAA67896.1 Sushi SAAS SAAS000436
Ligand	Lectin SAAS SAAS001304 EMBL AAA67896.1
PTM	Disulfide bond SAAS SAAS000436
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 38	38	Potential EMBL AAA67896.1
	Chain	39 – 376	338	L-selectin EMBL AAA67896.1		PRO_5000144599

Sequences

	Sequence		Length	Mass (Da)
	Q28629 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 59F6AD530F490947	FASTA	376	42,346
	10 20 30 40 50 60 MIFPWKCQSP QRGLWNVFKL WVWATLCCDF LAYHGTNCWT YHYSEKPMNW ERARKFCREN 70 80 90 100 110 120 YTDLVAIQNK GEIEYLEKTL PFSRSYYWIG IRKIGNIWTW VGTNKSLTAE AENWGEGEPN 130 140 150 160 170 180 NKKTKEDCVE IYIKRLRDSG KWNDDSCQKR KAALCYTASC HPGSCSGHGE CVEVINNYTC 190 200 210 220 230 240 SCDVGYYGPQ CQFVMQCEPL EAPELGTMAC THPLGEFSFS SQCGFSCLEG TNLTGIEETT 250 260 270 280 290 300 CGPLGNWSSL RPTCQVIQCE PLTAPDLGTI DCSHPRAVFG FTSTCTFSCS EGAELIGMKK 310 320 330 340 350 360 TVCGSSGIWS SPTPKCQKVD RSFSMIKEGD YNPLFIPVAV MVTAFSGLAF IIWLARRLKK 370 GKKSQKSKDD ILIHPL

References

[1]	"cDNA for rabbit L-selectin." Qian J., Marks R.M. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Kidney EMBL AAA67896.1.
[2]	"Cloning of the cDNA for rabbit L-selectin and expression of recombinant protein with a kinase target site to facilitate radiolabeling." Qian J., Huang X., Marks R.M. Biochem. Biophys. Res. Commun. 225:406-412(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U26535 mRNA. Translation: AAA67896.1.
PIR	JC4892.
RefSeq	NP_001075821.1. NM_001082352.1.
UniGene	Ocu.2027.
3D structure databases
HSSP	HSSP built from PDB template 1G1S based on UniProtKB P16109.
ProteinModelPortal	Q28629.
SMR	Q28629. Positions 39-194.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000017151.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100009204.
Organism-specific databases
CTD	6402.
Phylogenomic databases
eggNOG	NOG258998.
HOGENOM	HOG000236254.
HOVERGEN	HBG052375.
Family and domain databases
Gene3D	3.10.100.10. 1 hit.
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. IPR016187. C-type_lectin_fold. IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR016348. L-selectin. IPR002396. Selectin_superfamily. IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00008. EGF. 1 hit. PF00059. Lectin_C. 1 hit. PF00084. Sushi. 2 hits. [Graphical view]
PIRSF	PIRSF002421. L-selectin. 1 hit.
PRINTS	PR00343. SELECTIN.
SMART	SM00032. CCP. 2 hits. SM00034. CLECT. 1 hit. SM00181. EGF. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit. SSF57535. Complement_control_module. 2 hits.
PROSITE	PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit. PS00022. EGF_1. 1 hit. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 1 hit. PS50923. SUSHI. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q28629_RABIT

Accession

Primary (citable) accession number: Q28629

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)