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Q28629

- Q28629_RABIT

UniProt

Q28629 - Q28629_RABIT

Protein

L-selectin

Gene

SELL

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.UniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. response to ATP Source: Ensembl

    Keywords - Biological processi

    Cell adhesionUniRule annotation

    Keywords - Ligandi

    LectinImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-selectinUniRule annotation
    Gene namesi
    Name:SELLImported
    OrganismiOryctolagus cuniculus (Rabbit)Imported
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Chromosome 13

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838 PotentialImportedAdd
    BLAST
    Chaini39 – 376338L-selectinImportedPRO_5000144599Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000017151.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the selectin/LECAM family.UniRule annotation
    Contains C-type lectin domain.SAAS annotation

    Keywords - Domaini

    EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalImported, SushiSAAS annotation

    Phylogenomic databases

    eggNOGiNOG258998.
    GeneTreeiENSGT00750000117319.
    HOGENOMiHOG000236254.
    HOVERGENiHBG052375.
    TreeFamiTF326910.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR016348. L-selectin.
    IPR002396. Selectin_superfamily.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 2 hits.
    [Graphical view]
    PIRSFiPIRSF002421. L-selectin. 1 hit.
    PRINTSiPR00343. SELECTIN.
    SMARTiSM00032. CCP. 2 hits.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    SSF57535. SSF57535. 2 hits.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50923. SUSHI. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28629-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIFPWKCQSP QRGLWNVFKL WVWATLCCDF LAYHGTNCWT YHYSEKPMNW    50
    ERARKFCREN YTDLVAIQNK GEIEYLEKTL PFSRSYYWIG IRKIGNIWTW 100
    VGTNKSLTAE AENWGEGEPN NKKTKEDCVE IYIKRLRDSG KWNDDSCQKR 150
    KAALCYTASC HPGSCSGHGE CVEVINNYTC SCDVGYYGPQ CQFVMQCEPL 200
    EAPELGTMAC THPLGEFSFS SQCGFSCLEG TNLTGIEETT CGPLGNWSSL 250
    RPTCQVIQCE PLTAPDLGTI DCSHPRAVFG FTSTCTFSCS EGAELIGMKK 300
    TVCGSSGIWS SPTPKCQKVD RSFSMIKEGD YNPLFIPVAV MVTAFSGLAF 350
    IIWLARRLKK GKKSQKSKDD ILIHPL 376
    Length:376
    Mass (Da):42,346
    Last modified:November 1, 1996 - v1
    Checksum:i59F6AD530F490947
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAGW02000040 Genomic DNA. No translation available.
    AAGW02000041 Genomic DNA. No translation available.
    U26535 mRNA. Translation: AAA67896.1.
    PIRiJC4892.
    RefSeqiNP_001075821.1. NM_001082352.1.
    UniGeneiOcu.2027.

    Genome annotation databases

    EnsembliENSOCUT00000029156; ENSOCUP00000017151; ENSOCUG00000017432.
    GeneIDi100009204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAGW02000040 Genomic DNA. No translation available.
    AAGW02000041 Genomic DNA. No translation available.
    U26535 mRNA. Translation: AAA67896.1 .
    PIRi JC4892.
    RefSeqi NP_001075821.1. NM_001082352.1.
    UniGenei Ocu.2027.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000017151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000029156 ; ENSOCUP00000017151 ; ENSOCUG00000017432 .
    GeneIDi 100009204.

    Organism-specific databases

    CTDi 6402.

    Phylogenomic databases

    eggNOGi NOG258998.
    GeneTreei ENSGT00750000117319.
    HOGENOMi HOG000236254.
    HOVERGENi HBG052375.
    TreeFami TF326910.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR016348. L-selectin.
    IPR002396. Selectin_superfamily.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF002421. L-selectin. 1 hit.
    PRINTSi PR00343. SELECTIN.
    SMARTi SM00032. CCP. 2 hits.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    SSF57535. SSF57535. 2 hits.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50923. SUSHI. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA for rabbit L-selectin."
      Qian J., Marks R.M.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: KidneyImported.
    2. "Cloning of the cDNA for rabbit L-selectin and expression of recombinant protein with a kinase target site to facilitate radiolabeling."
      Qian J., Huang X., Marks R.M.
      Biochem. Biophys. Res. Commun. 225:406-412(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Genome Sequence of Oryctolagus cuniculus (European rabbit)."
      The Genome Sequencing Platform
      Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., Lindblad-Toh K.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ThorbeckeImported.
    4. "A high-resolution map of human evolutionary constraint using 29 mammals."
      Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.
      , Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.
      Nature 478:476-482(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ThorbeckeImported.
    5. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: ThorbeckeImported.

    Entry informationi

    Entry nameiQ28629_RABIT
    AccessioniPrimary (citable) accession number: Q28629
    Secondary accession number(s): G1TJM3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3