Reviewed, UniProtKB/Swiss-Prot Q28616 (AMHR2_RABIT)

Names and origin

Protein names

Recommended name:
    Anti-Muellerian hormone type-2 receptor
    EC=2.7.11.30
Alternative name(s):
    Anti-Muellerian hormone type II receptor
      Short name=AMH type II receptor
    MIS type II receptor
    MISRII
      Short name=MRII

Gene names

Name:

AMHR2

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane proteinBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 569	552	Anti-Muellerian hormone type-2 receptor		PRO_0000260266
Regions
	Topological domain	18 – 148	131	Extracellular Potential
	Transmembrane	149 – 169	21	Potential
	Topological domain	170 – 569	400	Cytoplasmic Potential
	Domain	201 – 511	311	Protein kinase
	Nucleotide binding	207 – 215	9	ATP By similarity
	Compositional bias	149 – 162	14	Poly-Leu
Sites
	Active site	331	1	Proton acceptor By similarity
	Binding site	228	1	ATP By similarity
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	119	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q28616-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 388800F0ECAA5AAB	FASTA	569	61,099
	10 20 30 40 50 60 MLGTLGLWAL LPAAVQAPPN RRTCVFFEAP GVRGSTKTLG ELLDAGPGPP RVIRCLYSRC 70 80 90 100 110 120 CFGIWNLTRD QAQVEMQGCR DSDEPGCESL SCDPSPRARA SSGSTLFTCS CGADFCNANY 130 140 150 160 170 180 SHLPPLGGPG TPGPQGPQAA PGESPWMALA LLGLVLLLLL LLGGIVVALL QRKAYRVQSG 190 200 210 220 230 240 PEPEPDSGRD CSEELPELPQ LCFSQVIREG GHAAVWAGQL QGELVAIKVF PRRAVAQFRA 250 260 270 280 290 300 ERALYELPGL QHNHVVRFIA AGQGGPGPLP SGPLLVLELH PKGSLCQYLS QHTSDWGSSL 310 320 330 340 350 360 RMALSLAQGL AFLHEERWQD GQYKPGIAHR DLSSQNVLIR EDGSCAIGDL GLALVLPGFA 370 380 390 400 410 420 QPRAWAPPQP RGPAAIMEAG TQRYMAPELL DKSLDLQDWG TALRRADVYS LALLLWEILS 430 440 450 460 470 480 RCPDLRPDGR PPPFQLAYEA ELGSAPTTCE LWALAVEERR RPDIPSSWCC FATDPGGLRE 490 500 510 520 530 540 LLEDCWDADP EARLTAECVQ QRLVALVHPQ EAQPCPEGRP HSHPEDWPPA PAPAPALLPG 550 560 SPQPGACHFG VQQGLCSRNP GAACASSDV

References

[1]

"Cloning, expression, and alternative splicing of the receptor for anti-Muellerian hormone." di Clemente N., Wilson C., Faure E., Boussin L., Carmillo P., Tizard R., Picard J.-Y., Vigier B., Josso N., Cate R. Mol. Endocrinol. 8:1006-1020(1994) [PubMed: 7997230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15025 mRNA. Translation: AAA21875.1.
RefSeq	NP_001076263.1.
UniGene	Ocu.1823
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
ModBase	Search...
Genome annotation databases
GeneID	100009599.
Phylogenomic databases
HOVERGEN	Q28616.
Family and domain databases
InterPro	IPR017193. Anti-muellerian_hrmn_rcpt_II. IPR015771. Anti-muellerian_hrmn_rcpt_II_C. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
PANTHER	PTHR23255:SF4. MIS_II_R. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PIRSF	PIRSF037392. AMHRII. 1 hit.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMHR2_RABIT

Accession

Primary (citable) accession number: Q28616

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)