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Q28616

- AMHR2_RABIT

UniProt

Q28616 - AMHR2_RABIT

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Protein

Anti-Muellerian hormone type-2 receptor

Gene

AMHR2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei228 – 2281ATPPROSITE-ProRule annotation
Active sitei331 – 3311Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi207 – 2159ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transmembrane receptor protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name:
AMH type II receptor
MIS type II receptor
Short name:
MISRII
Short name:
MRII
Gene namesi
Name:AMHR2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 148131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Topological domaini170 – 569400CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 569552Anti-Muellerian hormone type-2 receptorPRO_0000260266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003591.

Structurei

3D structure databases

ProteinModelPortaliQ28616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 511311Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi149 – 16214Poly-LeuAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG243040.
HOGENOMiHOG000033920.
HOVERGENiHBG097461.
InParanoidiQ28616.

Family and domain databases

InterProiIPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037392. AMHRII. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28616-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGTLGLWAL LPAAVQAPPN RRTCVFFEAP GVRGSTKTLG ELLDAGPGPP
60 70 80 90 100
RVIRCLYSRC CFGIWNLTRD QAQVEMQGCR DSDEPGCESL SCDPSPRARA
110 120 130 140 150
SSGSTLFTCS CGADFCNANY SHLPPLGGPG TPGPQGPQAA PGESPWMALA
160 170 180 190 200
LLGLVLLLLL LLGGIVVALL QRKAYRVQSG PEPEPDSGRD CSEELPELPQ
210 220 230 240 250
LCFSQVIREG GHAAVWAGQL QGELVAIKVF PRRAVAQFRA ERALYELPGL
260 270 280 290 300
QHNHVVRFIA AGQGGPGPLP SGPLLVLELH PKGSLCQYLS QHTSDWGSSL
310 320 330 340 350
RMALSLAQGL AFLHEERWQD GQYKPGIAHR DLSSQNVLIR EDGSCAIGDL
360 370 380 390 400
GLALVLPGFA QPRAWAPPQP RGPAAIMEAG TQRYMAPELL DKSLDLQDWG
410 420 430 440 450
TALRRADVYS LALLLWEILS RCPDLRPDGR PPPFQLAYEA ELGSAPTTCE
460 470 480 490 500
LWALAVEERR RPDIPSSWCC FATDPGGLRE LLEDCWDADP EARLTAECVQ
510 520 530 540 550
QRLVALVHPQ EAQPCPEGRP HSHPEDWPPA PAPAPALLPG SPQPGACHFG
560
VQQGLCSRNP GAACASSDV
Length:569
Mass (Da):61,099
Last modified:November 1, 1996 - v1
Checksum:i388800F0ECAA5AAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15025 mRNA. Translation: AAA21875.1.
RefSeqiNP_001076263.1. NM_001082794.1.
UniGeneiOcu.1823.

Genome annotation databases

GeneIDi100009599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15025 mRNA. Translation: AAA21875.1 .
RefSeqi NP_001076263.1. NM_001082794.1.
UniGenei Ocu.1823.

3D structure databases

ProteinModelPortali Q28616.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000003591.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009599.

Organism-specific databases

CTDi 269.

Phylogenomic databases

eggNOGi NOG243040.
HOGENOMi HOG000033920.
HOVERGENi HBG097461.
InParanoidi Q28616.

Family and domain databases

InterProi IPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF037392. AMHRII. 1 hit.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression, and alternative splicing of the receptor for anti-Muellerian hormone."
    di Clemente N., Wilson C., Faure E., Boussin L., Carmillo P., Tizard R., Picard J.-Y., Vigier B., Josso N., Cate R.
    Mol. Endocrinol. 8:1006-1020(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiAMHR2_RABIT
AccessioniPrimary (citable) accession number: Q28616
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3