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Q28616 (AMHR2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anti-Muellerian hormone type-2 receptor

EC=2.7.11.30
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name=AMH type II receptor
MIS type II receptor
Short name=MISRII
Short name=MRII
Gene names
Name:AMHR2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 569552Anti-Muellerian hormone type-2 receptor
PRO_0000260266

Regions

Topological domain18 – 148131Extracellular Potential
Transmembrane149 – 16921Helical; Potential
Topological domain170 – 569400Cytoplasmic Potential
Domain201 – 511311Protein kinase
Nucleotide binding207 – 2159ATP By similarity
Compositional bias149 – 16214Poly-Leu

Sites

Active site3311Proton acceptor By similarity
Binding site2281ATP By similarity

Amino acid modifications

Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q28616 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 388800F0ECAA5AAB

FASTA56961,099
        10         20         30         40         50         60 
MLGTLGLWAL LPAAVQAPPN RRTCVFFEAP GVRGSTKTLG ELLDAGPGPP RVIRCLYSRC 

        70         80         90        100        110        120 
CFGIWNLTRD QAQVEMQGCR DSDEPGCESL SCDPSPRARA SSGSTLFTCS CGADFCNANY 

       130        140        150        160        170        180 
SHLPPLGGPG TPGPQGPQAA PGESPWMALA LLGLVLLLLL LLGGIVVALL QRKAYRVQSG 

       190        200        210        220        230        240 
PEPEPDSGRD CSEELPELPQ LCFSQVIREG GHAAVWAGQL QGELVAIKVF PRRAVAQFRA 

       250        260        270        280        290        300 
ERALYELPGL QHNHVVRFIA AGQGGPGPLP SGPLLVLELH PKGSLCQYLS QHTSDWGSSL 

       310        320        330        340        350        360 
RMALSLAQGL AFLHEERWQD GQYKPGIAHR DLSSQNVLIR EDGSCAIGDL GLALVLPGFA 

       370        380        390        400        410        420 
QPRAWAPPQP RGPAAIMEAG TQRYMAPELL DKSLDLQDWG TALRRADVYS LALLLWEILS 

       430        440        450        460        470        480 
RCPDLRPDGR PPPFQLAYEA ELGSAPTTCE LWALAVEERR RPDIPSSWCC FATDPGGLRE 

       490        500        510        520        530        540 
LLEDCWDADP EARLTAECVQ QRLVALVHPQ EAQPCPEGRP HSHPEDWPPA PAPAPALLPG 

       550        560 
SPQPGACHFG VQQGLCSRNP GAACASSDV 

« Hide

References

[1]"Cloning, expression, and alternative splicing of the receptor for anti-Muellerian hormone."
di Clemente N., Wilson C., Faure E., Boussin L., Carmillo P., Tizard R., Picard J.-Y., Vigier B., Josso N., Cate R.
Mol. Endocrinol. 8:1006-1020(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15025 mRNA. Translation: AAA21875.1.
RefSeqNP_001076263.1. NM_001082794.1.
UniGeneOcu.1823.

3D structure databases

ProteinModelPortalQ28616.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000003591.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009599.

Organism-specific databases

CTD269.

Phylogenomic databases

eggNOGNOG243040.
HOGENOMHOG000033920.
HOVERGENHBG097461.

Family and domain databases

InterProIPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERPTHR23255:SF4. PTHR23255:SF4. 1 hit.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF037392. AMHRII. 1 hit.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMHR2_RABIT
AccessionPrimary (citable) accession number: Q28616
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families