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Protein

Anti-Muellerian hormone type-2 receptor

Gene

AMHR2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228ATPPROSITE-ProRule annotation1
Active sitei331Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 215ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name:
AMH type II receptor
MIS type II receptor
Short name:
MISRII
Short name:
MRII
Gene namesi
Name:AMHR2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 148ExtracellularSequence analysisAdd BLAST131
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 569CytoplasmicSequence analysisAdd BLAST400

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000026026618 – 569Anti-Muellerian hormone type-2 receptorAdd BLAST552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 79By similarity
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi92 ↔ 109By similarity
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ28616

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003591

Structurei

3D structure databases

ProteinModelPortaliQ28616
SMRiQ28616
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 511Protein kinasePROSITE-ProRule annotationAdd BLAST311

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi149 – 162Poly-LeuAdd BLAST14

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653 Eukaryota
ENOG410XS2Z LUCA
HOGENOMiHOG000033920
HOVERGENiHBG097461
InParanoidiQ28616
KOiK04672

Family and domain databases

InterProiView protein in InterPro
IPR015771 Anti-muellerian_hrmn_rcpt_II
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF037392 AMHRII, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTLGLWAL LPAAVQAPPN RRTCVFFEAP GVRGSTKTLG ELLDAGPGPP
60 70 80 90 100
RVIRCLYSRC CFGIWNLTRD QAQVEMQGCR DSDEPGCESL SCDPSPRARA
110 120 130 140 150
SSGSTLFTCS CGADFCNANY SHLPPLGGPG TPGPQGPQAA PGESPWMALA
160 170 180 190 200
LLGLVLLLLL LLGGIVVALL QRKAYRVQSG PEPEPDSGRD CSEELPELPQ
210 220 230 240 250
LCFSQVIREG GHAAVWAGQL QGELVAIKVF PRRAVAQFRA ERALYELPGL
260 270 280 290 300
QHNHVVRFIA AGQGGPGPLP SGPLLVLELH PKGSLCQYLS QHTSDWGSSL
310 320 330 340 350
RMALSLAQGL AFLHEERWQD GQYKPGIAHR DLSSQNVLIR EDGSCAIGDL
360 370 380 390 400
GLALVLPGFA QPRAWAPPQP RGPAAIMEAG TQRYMAPELL DKSLDLQDWG
410 420 430 440 450
TALRRADVYS LALLLWEILS RCPDLRPDGR PPPFQLAYEA ELGSAPTTCE
460 470 480 490 500
LWALAVEERR RPDIPSSWCC FATDPGGLRE LLEDCWDADP EARLTAECVQ
510 520 530 540 550
QRLVALVHPQ EAQPCPEGRP HSHPEDWPPA PAPAPALLPG SPQPGACHFG
560
VQQGLCSRNP GAACASSDV
Length:569
Mass (Da):61,099
Last modified:November 1, 1996 - v1
Checksum:i388800F0ECAA5AAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15025 mRNA Translation: AAA21875.1
RefSeqiNP_001076263.1, NM_001082794.1
UniGeneiOcu.1823

Genome annotation databases

GeneIDi100009599
KEGGiocu:100009599

Similar proteinsi

Entry informationi

Entry nameiAMHR2_RABIT
AccessioniPrimary (citable) accession number: Q28616
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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