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Protein

Anti-Muellerian hormone type-2 receptor

Gene

AMHR2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228ATPPROSITE-ProRule annotation1
Active sitei331Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 215ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name:
AMH type II receptor
MIS type II receptor
Short name:
MISRII
Short name:
MRII
Gene namesi
Name:AMHR2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 148ExtracellularSequence analysisAdd BLAST131
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 569CytoplasmicSequence analysisAdd BLAST400

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000026026618 – 569Anti-Muellerian hormone type-2 receptorAdd BLAST552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 79By similarity
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi92 ↔ 109By similarity
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003591.

Structurei

3D structure databases

ProteinModelPortaliQ28616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 511Protein kinasePROSITE-ProRule annotationAdd BLAST311

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi149 – 162Poly-LeuAdd BLAST14

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
HOGENOMiHOG000033920.
HOVERGENiHBG097461.
InParanoidiQ28616.
KOiK04672.

Family and domain databases

InterProiIPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037392. AMHRII. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTLGLWAL LPAAVQAPPN RRTCVFFEAP GVRGSTKTLG ELLDAGPGPP
60 70 80 90 100
RVIRCLYSRC CFGIWNLTRD QAQVEMQGCR DSDEPGCESL SCDPSPRARA
110 120 130 140 150
SSGSTLFTCS CGADFCNANY SHLPPLGGPG TPGPQGPQAA PGESPWMALA
160 170 180 190 200
LLGLVLLLLL LLGGIVVALL QRKAYRVQSG PEPEPDSGRD CSEELPELPQ
210 220 230 240 250
LCFSQVIREG GHAAVWAGQL QGELVAIKVF PRRAVAQFRA ERALYELPGL
260 270 280 290 300
QHNHVVRFIA AGQGGPGPLP SGPLLVLELH PKGSLCQYLS QHTSDWGSSL
310 320 330 340 350
RMALSLAQGL AFLHEERWQD GQYKPGIAHR DLSSQNVLIR EDGSCAIGDL
360 370 380 390 400
GLALVLPGFA QPRAWAPPQP RGPAAIMEAG TQRYMAPELL DKSLDLQDWG
410 420 430 440 450
TALRRADVYS LALLLWEILS RCPDLRPDGR PPPFQLAYEA ELGSAPTTCE
460 470 480 490 500
LWALAVEERR RPDIPSSWCC FATDPGGLRE LLEDCWDADP EARLTAECVQ
510 520 530 540 550
QRLVALVHPQ EAQPCPEGRP HSHPEDWPPA PAPAPALLPG SPQPGACHFG
560
VQQGLCSRNP GAACASSDV
Length:569
Mass (Da):61,099
Last modified:November 1, 1996 - v1
Checksum:i388800F0ECAA5AAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15025 mRNA. Translation: AAA21875.1.
RefSeqiNP_001076263.1. NM_001082794.1.
UniGeneiOcu.1823.

Genome annotation databases

GeneIDi100009599.
KEGGiocu:100009599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15025 mRNA. Translation: AAA21875.1.
RefSeqiNP_001076263.1. NM_001082794.1.
UniGeneiOcu.1823.

3D structure databases

ProteinModelPortaliQ28616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009599.
KEGGiocu:100009599.

Organism-specific databases

CTDi269.

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
HOGENOMiHOG000033920.
HOVERGENiHBG097461.
InParanoidiQ28616.
KOiK04672.

Family and domain databases

InterProiIPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037392. AMHRII. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMHR2_RABIT
AccessioniPrimary (citable) accession number: Q28616
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.