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Q28616

- AMHR2_RABIT

UniProt

Q28616 - AMHR2_RABIT

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Protein
Anti-Muellerian hormone type-2 receptor
Gene
AMHR2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei228 – 2281ATP By similarity
Active sitei331 – 3311Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi207 – 2159ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transmembrane receptor protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
    Alternative name(s):
    Anti-Muellerian hormone type II receptor
    Short name:
    AMH type II receptor
    MIS type II receptor
    Short name:
    MISRII
    Short name:
    MRII
    Gene namesi
    Name:AMHR2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 148131Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei149 – 16921Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini170 – 569400Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717 Reviewed prediction
    Add
    BLAST
    Chaini18 – 569552Anti-Muellerian hormone type-2 receptor
    PRO_0000260266Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000003591.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28616.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini201 – 511311Protein kinase
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi149 – 16214Poly-Leu
    Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG243040.
    HOGENOMiHOG000033920.
    HOVERGENiHBG097461.

    Family and domain databases

    InterProiIPR015771. Anti-muellerian_hrmn_rcpt_II.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037392. AMHRII. 1 hit.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28616-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGTLGLWAL LPAAVQAPPN RRTCVFFEAP GVRGSTKTLG ELLDAGPGPP    50
    RVIRCLYSRC CFGIWNLTRD QAQVEMQGCR DSDEPGCESL SCDPSPRARA 100
    SSGSTLFTCS CGADFCNANY SHLPPLGGPG TPGPQGPQAA PGESPWMALA 150
    LLGLVLLLLL LLGGIVVALL QRKAYRVQSG PEPEPDSGRD CSEELPELPQ 200
    LCFSQVIREG GHAAVWAGQL QGELVAIKVF PRRAVAQFRA ERALYELPGL 250
    QHNHVVRFIA AGQGGPGPLP SGPLLVLELH PKGSLCQYLS QHTSDWGSSL 300
    RMALSLAQGL AFLHEERWQD GQYKPGIAHR DLSSQNVLIR EDGSCAIGDL 350
    GLALVLPGFA QPRAWAPPQP RGPAAIMEAG TQRYMAPELL DKSLDLQDWG 400
    TALRRADVYS LALLLWEILS RCPDLRPDGR PPPFQLAYEA ELGSAPTTCE 450
    LWALAVEERR RPDIPSSWCC FATDPGGLRE LLEDCWDADP EARLTAECVQ 500
    QRLVALVHPQ EAQPCPEGRP HSHPEDWPPA PAPAPALLPG SPQPGACHFG 550
    VQQGLCSRNP GAACASSDV 569
    Length:569
    Mass (Da):61,099
    Last modified:November 1, 1996 - v1
    Checksum:i388800F0ECAA5AAB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15025 mRNA. Translation: AAA21875.1.
    RefSeqiNP_001076263.1. NM_001082794.1.
    UniGeneiOcu.1823.

    Genome annotation databases

    GeneIDi100009599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15025 mRNA. Translation: AAA21875.1 .
    RefSeqi NP_001076263.1. NM_001082794.1.
    UniGenei Ocu.1823.

    3D structure databases

    ProteinModelPortali Q28616.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000003591.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100009599.

    Organism-specific databases

    CTDi 269.

    Phylogenomic databases

    eggNOGi NOG243040.
    HOGENOMi HOG000033920.
    HOVERGENi HBG097461.

    Family and domain databases

    InterProi IPR015771. Anti-muellerian_hrmn_rcpt_II.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037392. AMHRII. 1 hit.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and alternative splicing of the receptor for anti-Muellerian hormone."
      di Clemente N., Wilson C., Faure E., Boussin L., Carmillo P., Tizard R., Picard J.-Y., Vigier B., Josso N., Cate R.
      Mol. Endocrinol. 8:1006-1020(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiAMHR2_RABIT
    AccessioniPrimary (citable) accession number: Q28616
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 1, 1996
    Last modified: September 3, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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