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Q28614

- UT2_RABIT

UniProt

Q28614 - UT2_RABIT

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Protein

Urea transporter 2

Gene
SLC14A2, UT2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.1 Publication

GO - Molecular functioni

  1. urea transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
Vasopressin-regulated urea transporter
Gene namesi
Name:SLC14A2
Synonyms:UT2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8518Helical; Reviewed predictionAdd
BLAST
Transmembranei92 – 10918Helical; Reviewed predictionAdd
BLAST
Transmembranei115 – 13521Helical; Reviewed predictionAdd
BLAST
Transmembranei143 – 16321Helical; Reviewed predictionAdd
BLAST
Transmembranei172 – 19221Helical; Reviewed predictionAdd
BLAST
Transmembranei239 – 25719Helical; Reviewed predictionAdd
BLAST
Transmembranei264 – 28017Helical; Reviewed predictionAdd
BLAST
Transmembranei287 – 30317Helical; Reviewed predictionAdd
BLAST
Transmembranei309 – 32921Helical; Reviewed predictionAdd
BLAST
Transmembranei331 – 35121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Urea transporter 2PRO_0000065740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Kidney.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005837.

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4413.
HOGENOMiHOG000065705.
HOVERGENiHBG000540.
OMAiPSEREMY.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 1 hit.
[Graphical view]
PIRSFiPIRSF016502. Urea_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28614-1 [UniParc]FASTAAdd to Basket

« Hide

MEDSSEIKVE TASSRTSWIQ SSVAAGGKRI SRALGYITGE MKECAEGLKD    50
KSPVFQFLDW VLRGTSQVMF VNNPLSGILI VIGLFVQNPW WAIAGCLGTV 100
MSTLTALILS QDRSAIASGL HGYNGVLVGL LIAVFSDKGD YYWWLLLPVI 150
VMSMSCPILS SALGTIFSKW DLPVFTLPFN IAVTLYLAAT GHYNLFFPTT 200
LLQPVSSVPN ITWSEIQVPL LLRAIPVGIG QVYGCDNPWT GGIFLIALFI 250
SSPLICLHAA IGSTMGMLAA LTIATPFDSI YFGLCGFNST LACIAVGGMF 300
YVITWQTHLL AVACALFAAY VGAALTNVLS VFGLPTCTWP FCISALIFLL 350
LTTNNPAIYK LPLSKVTYPE ANRTYYLTQE RNRRSSTITK YQAYDVS 397
Length:397
Mass (Da):43,136
Last modified:November 1, 1997 - v1
Checksum:iD99B7968B078C44A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10358 mRNA. Translation: AAA19008.1.
PIRiS38283.
RefSeqiNP_001075809.1. NM_001082340.1.
UniGeneiOcu.1819.

Genome annotation databases

GeneIDi100009190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10358 mRNA. Translation: AAA19008.1 .
PIRi S38283.
RefSeqi NP_001075809.1. NM_001082340.1.
UniGenei Ocu.1819.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000005837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009190.

Organism-specific databases

CTDi 8170.

Phylogenomic databases

eggNOGi COG4413.
HOGENOMi HOG000065705.
HOVERGENi HBG000540.
OMAi PSEREMY.

Family and domain databases

Gene3Di 1.10.3430.10. 1 hit.
InterProi IPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view ]
PANTHERi PTHR10464. PTHR10464. 1 hit.
Pfami PF03253. UT. 1 hit.
[Graphical view ]
PIRSFi PIRSF016502. Urea_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the vasopressin-regulated urea transporter."
    You G., Smith C.P., Kanai Y., Lee W.-S., Stelzner M., Hediger M.A.
    Nature 365:844-847(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.

Entry informationi

Entry nameiUT2_RABIT
AccessioniPrimary (citable) accession number: Q28614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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