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Protein

Urea transporter 2

Gene

SLC14A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
Vasopressin-regulated urea transporter
Gene namesi
Name:SLC14A2
Synonyms:UT2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 85HelicalSequence analysisAdd BLAST18
Transmembranei92 – 109HelicalSequence analysisAdd BLAST18
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei239 – 257HelicalSequence analysisAdd BLAST19
Transmembranei264 – 280HelicalSequence analysisAdd BLAST17
Transmembranei287 – 303HelicalSequence analysisAdd BLAST17
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657401 – 397Urea transporter 2Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Kidney.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005837.

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEWG. Eukaryota.
COG4413. LUCA.
HOGENOMiHOG000065705.
HOVERGENiHBG000540.
InParanoidiQ28614.
KOiK08716.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 1 hit.
[Graphical view]
PIRSFiPIRSF016502. Urea_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSSEIKVE TASSRTSWIQ SSVAAGGKRI SRALGYITGE MKECAEGLKD
60 70 80 90 100
KSPVFQFLDW VLRGTSQVMF VNNPLSGILI VIGLFVQNPW WAIAGCLGTV
110 120 130 140 150
MSTLTALILS QDRSAIASGL HGYNGVLVGL LIAVFSDKGD YYWWLLLPVI
160 170 180 190 200
VMSMSCPILS SALGTIFSKW DLPVFTLPFN IAVTLYLAAT GHYNLFFPTT
210 220 230 240 250
LLQPVSSVPN ITWSEIQVPL LLRAIPVGIG QVYGCDNPWT GGIFLIALFI
260 270 280 290 300
SSPLICLHAA IGSTMGMLAA LTIATPFDSI YFGLCGFNST LACIAVGGMF
310 320 330 340 350
YVITWQTHLL AVACALFAAY VGAALTNVLS VFGLPTCTWP FCISALIFLL
360 370 380 390
LTTNNPAIYK LPLSKVTYPE ANRTYYLTQE RNRRSSTITK YQAYDVS
Length:397
Mass (Da):43,136
Last modified:November 1, 1997 - v1
Checksum:iD99B7968B078C44A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10358 mRNA. Translation: AAA19008.1.
PIRiS38283.
RefSeqiNP_001075809.1. NM_001082340.1.
UniGeneiOcu.1819.

Genome annotation databases

GeneIDi100009190.
KEGGiocu:100009190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10358 mRNA. Translation: AAA19008.1.
PIRiS38283.
RefSeqiNP_001075809.1. NM_001082340.1.
UniGeneiOcu.1819.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009190.
KEGGiocu:100009190.

Organism-specific databases

CTDi8170.

Phylogenomic databases

eggNOGiENOG410IEWG. Eukaryota.
COG4413. LUCA.
HOGENOMiHOG000065705.
HOVERGENiHBG000540.
InParanoidiQ28614.
KOiK08716.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 1 hit.
[Graphical view]
PIRSFiPIRSF016502. Urea_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUT2_RABIT
AccessioniPrimary (citable) accession number: Q28614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.