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Q28614

- UT2_RABIT

UniProt

Q28614 - UT2_RABIT

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Protein

Urea transporter 2

Gene

SLC14A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.1 Publication

GO - Molecular functioni

  1. urea transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
Vasopressin-regulated urea transporter
Gene namesi
Name:SLC14A2
Synonyms:UT2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8518HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 10918HelicalSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25719HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28017HelicalSequence AnalysisAdd
BLAST
Transmembranei287 – 30317HelicalSequence AnalysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence AnalysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Urea transporter 2PRO_0000065740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Kidney.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005837.

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4413.
HOGENOMiHOG000065705.
HOVERGENiHBG000540.
InParanoidiQ28614.
OMAiPSEREMY.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 1 hit.
[Graphical view]
PIRSFiPIRSF016502. Urea_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28614-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDSSEIKVE TASSRTSWIQ SSVAAGGKRI SRALGYITGE MKECAEGLKD
60 70 80 90 100
KSPVFQFLDW VLRGTSQVMF VNNPLSGILI VIGLFVQNPW WAIAGCLGTV
110 120 130 140 150
MSTLTALILS QDRSAIASGL HGYNGVLVGL LIAVFSDKGD YYWWLLLPVI
160 170 180 190 200
VMSMSCPILS SALGTIFSKW DLPVFTLPFN IAVTLYLAAT GHYNLFFPTT
210 220 230 240 250
LLQPVSSVPN ITWSEIQVPL LLRAIPVGIG QVYGCDNPWT GGIFLIALFI
260 270 280 290 300
SSPLICLHAA IGSTMGMLAA LTIATPFDSI YFGLCGFNST LACIAVGGMF
310 320 330 340 350
YVITWQTHLL AVACALFAAY VGAALTNVLS VFGLPTCTWP FCISALIFLL
360 370 380 390
LTTNNPAIYK LPLSKVTYPE ANRTYYLTQE RNRRSSTITK YQAYDVS
Length:397
Mass (Da):43,136
Last modified:November 1, 1997 - v1
Checksum:iD99B7968B078C44A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10358 mRNA. Translation: AAA19008.1.
PIRiS38283.
RefSeqiNP_001075809.1. NM_001082340.1.
UniGeneiOcu.1819.

Genome annotation databases

GeneIDi100009190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10358 mRNA. Translation: AAA19008.1 .
PIRi S38283.
RefSeqi NP_001075809.1. NM_001082340.1.
UniGenei Ocu.1819.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000005837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009190.

Organism-specific databases

CTDi 8170.

Phylogenomic databases

eggNOGi COG4413.
HOGENOMi HOG000065705.
HOVERGENi HBG000540.
InParanoidi Q28614.
OMAi PSEREMY.

Family and domain databases

Gene3Di 1.10.3430.10. 1 hit.
InterProi IPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view ]
PANTHERi PTHR10464. PTHR10464. 1 hit.
Pfami PF03253. UT. 1 hit.
[Graphical view ]
PIRSFi PIRSF016502. Urea_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the vasopressin-regulated urea transporter."
    You G., Smith C.P., Kanai Y., Lee W.-S., Stelzner M., Hediger M.A.
    Nature 365:844-847(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.

Entry informationi

Entry nameiUT2_RABIT
AccessioniPrimary (citable) accession number: Q28614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3