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Q28614 (UT2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
Vasopressin-regulated urea transporter
Gene names
Name:SLC14A2
Synonyms:UT2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Ref.1

Subcellular location

Apical cell membrane; Multi-pass membrane protein.

Tissue specificity

Kidney. Ref.1

Sequence similarities

Belongs to the urea transporter family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionurea transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Urea transporter 2
PRO_0000065740

Regions

Transmembrane68 – 8518Helical; Potential
Transmembrane92 – 10918Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane172 – 19221Helical; Potential
Transmembrane239 – 25719Helical; Potential
Transmembrane264 – 28017Helical; Potential
Transmembrane287 – 30317Helical; Potential
Transmembrane309 – 32921Helical; Potential
Transmembrane331 – 35121Helical; Potential

Amino acid modifications

Glycosylation2101N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q28614 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: D99B7968B078C44A

FASTA39743,136
        10         20         30         40         50         60 
MEDSSEIKVE TASSRTSWIQ SSVAAGGKRI SRALGYITGE MKECAEGLKD KSPVFQFLDW 

        70         80         90        100        110        120 
VLRGTSQVMF VNNPLSGILI VIGLFVQNPW WAIAGCLGTV MSTLTALILS QDRSAIASGL 

       130        140        150        160        170        180 
HGYNGVLVGL LIAVFSDKGD YYWWLLLPVI VMSMSCPILS SALGTIFSKW DLPVFTLPFN 

       190        200        210        220        230        240 
IAVTLYLAAT GHYNLFFPTT LLQPVSSVPN ITWSEIQVPL LLRAIPVGIG QVYGCDNPWT 

       250        260        270        280        290        300 
GGIFLIALFI SSPLICLHAA IGSTMGMLAA LTIATPFDSI YFGLCGFNST LACIAVGGMF 

       310        320        330        340        350        360 
YVITWQTHLL AVACALFAAY VGAALTNVLS VFGLPTCTWP FCISALIFLL LTTNNPAIYK 

       370        380        390 
LPLSKVTYPE ANRTYYLTQE RNRRSSTITK YQAYDVS 

« Hide

References

[1]"Cloning and characterization of the vasopressin-regulated urea transporter."
You G., Smith C.P., Kanai Y., Lee W.-S., Stelzner M., Hediger M.A.
Nature 365:844-847(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10358 mRNA. Translation: AAA19008.1.
PIRS38283.
RefSeqNP_001075809.1. NM_001082340.1.
UniGeneOcu.1819.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000005837.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009190.

Organism-specific databases

CTD8170.

Phylogenomic databases

eggNOGCOG4413.
HOGENOMHOG000065705.
HOVERGENHBG000540.
OMAPSEREMY.

Family and domain databases

Gene3D1.10.3430.10. 1 hit.
InterProIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERPTHR10464. PTHR10464. 1 hit.
PfamPF03253. UT. 1 hit.
[Graphical view]
PIRSFPIRSF016502. Urea_transporter. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUT2_RABIT
AccessionPrimary (citable) accession number: Q28614
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families