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Q28614

- UT2_RABIT

UniProt

Q28614 - UT2_RABIT

Protein

Urea transporter 2

Gene

SLC14A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.1 Publication

    GO - Molecular functioni

    1. urea transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urea transporter 2
    Alternative name(s):
    Solute carrier family 14 member 2
    Urea transporter, kidney
    Vasopressin-regulated urea transporter
    Gene namesi
    Name:SLC14A2
    Synonyms:UT2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Urea transporter 2PRO_0000065740Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Kidney.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000005837.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 8518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 10918HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28017HelicalSequence AnalysisAdd
    BLAST
    Transmembranei287 – 30317HelicalSequence AnalysisAdd
    BLAST
    Transmembranei309 – 32921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the urea transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4413.
    HOGENOMiHOG000065705.
    HOVERGENiHBG000540.
    OMAiPSEREMY.

    Family and domain databases

    Gene3Di1.10.3430.10. 1 hit.
    InterProiIPR029020. Ammonium/urea_transptr.
    IPR004937. Urea_transporter.
    [Graphical view]
    PANTHERiPTHR10464. PTHR10464. 1 hit.
    PfamiPF03253. UT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016502. Urea_transporter. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q28614-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDSSEIKVE TASSRTSWIQ SSVAAGGKRI SRALGYITGE MKECAEGLKD    50
    KSPVFQFLDW VLRGTSQVMF VNNPLSGILI VIGLFVQNPW WAIAGCLGTV 100
    MSTLTALILS QDRSAIASGL HGYNGVLVGL LIAVFSDKGD YYWWLLLPVI 150
    VMSMSCPILS SALGTIFSKW DLPVFTLPFN IAVTLYLAAT GHYNLFFPTT 200
    LLQPVSSVPN ITWSEIQVPL LLRAIPVGIG QVYGCDNPWT GGIFLIALFI 250
    SSPLICLHAA IGSTMGMLAA LTIATPFDSI YFGLCGFNST LACIAVGGMF 300
    YVITWQTHLL AVACALFAAY VGAALTNVLS VFGLPTCTWP FCISALIFLL 350
    LTTNNPAIYK LPLSKVTYPE ANRTYYLTQE RNRRSSTITK YQAYDVS 397
    Length:397
    Mass (Da):43,136
    Last modified:November 1, 1997 - v1
    Checksum:iD99B7968B078C44A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10358 mRNA. Translation: AAA19008.1.
    PIRiS38283.
    RefSeqiNP_001075809.1. NM_001082340.1.
    UniGeneiOcu.1819.

    Genome annotation databases

    GeneIDi100009190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10358 mRNA. Translation: AAA19008.1 .
    PIRi S38283.
    RefSeqi NP_001075809.1. NM_001082340.1.
    UniGenei Ocu.1819.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000005837.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100009190.

    Organism-specific databases

    CTDi 8170.

    Phylogenomic databases

    eggNOGi COG4413.
    HOGENOMi HOG000065705.
    HOVERGENi HBG000540.
    OMAi PSEREMY.

    Family and domain databases

    Gene3Di 1.10.3430.10. 1 hit.
    InterProi IPR029020. Ammonium/urea_transptr.
    IPR004937. Urea_transporter.
    [Graphical view ]
    PANTHERi PTHR10464. PTHR10464. 1 hit.
    Pfami PF03253. UT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016502. Urea_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the vasopressin-regulated urea transporter."
      You G., Smith C.P., Kanai Y., Lee W.-S., Stelzner M., Hediger M.A.
      Nature 365:844-847(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Kidney.

    Entry informationi

    Entry nameiUT2_RABIT
    AccessioniPrimary (citable) accession number: Q28614
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3