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Protein
Submitted name:

Glomerular epithelial protein 1

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

  • phosphatase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB
  • Wnt-protein binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Glomerular epithelial protein 1Imported
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei819 – 84325HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 11871158Sequence analysisPRO_5004203591Add
BLAST

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000684.

Structurei

3D structure databases

ProteinModelPortaliQ28613.
SMRiQ28613. Positions 887-1179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini328 – 42497Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini434 – 53097Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini531 – 62797Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini630 – 72394Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini724 – 81693Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini909 – 1166258Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1083 – 115775TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115792.
HOVERGENiHBG053763.
KOiK18035.
OrthoDBiEOG7PCJFZ.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 5 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLPTRARG RRRLLPLLWL FVLLKTAAAF HVTVRDDNSI VVSLEASDVI
60 70 80 90 100
SPASVYVVKI TGESKNYFFE FEEFNSTLPP PVIFKANYHG LYYIITLVVV
110 120 130 140 150
NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
TRVNISYWEG KAFRTMLYKD FFKGKTVFNH WLPGICYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVEYSG VSHEPKQHRT APYPPRNISV RIVNLNKNNW EEQSGSFPEE
260 270 280 290 300
SFMRSPETIE KDRIFHFTEE TPEPSGNISS GWPDFNSSDY ETTSQPYWWD
310 320 330 340 350
SASATPESED EFVSVLPMEY ENNNTLSEAE KPTPAPFSFF PVQMILSWLP
360 370 380 390 400
PKPPTAFDGF HIHIEREENF TEYSTVDEEA HEFVAELKEP GKYKLSVTTF
410 420 430 440 450
SASGSCETRE SQSAKSLSFY ISPTGEWIEE LTEKPQHVSV HVLSSTTALM
460 470 480 490 500
SWTSSQENYN STIVSVVSLT CQKQKESQRL EKQYCTQVNS SKRIIENLVP
510 520 530 540 550
GAQYQVVMYL RKGPLIGPPS DPVTFAIVPT GIKDLMLYPL GPTAVVLSWT
560 570 580 590 600
RPYLGVFRKY VVEMFYFNPA TMTSEWTTYY EIAATVSLTA SVRIANLLPA
610 620 630 640 650
WYYNFRVTMV TWGDPELSCC DSSTISFITA PVAPEITSVE YFNSLLYISW
660 670 680 690 700
TYGDDTTDLS HSRMLHWMVV AEGKKKIKKS VTRNVMTAIL SLPPGDIYNL
710 720 730 740 750
SVTACTERGS NTSMLRLVKL EPAPPKSLFA VNKTQTSVTL LWVEEGVADF
760 770 780 790 800
FEVFCQQVGS GLETKLQEPV AVSSHVVTIS SLLPATAYNC SVTSFSHDSP
810 820 830 840 850
SVPTFIAVST MVTEMNPNVV VISVLAILST LLIGLLLVTL IILRKKHLQM
860 870 880 890 900
ARECGAGTFV NFASLERDGK LPYNWSKNGL KKRKLTNPVQ LDDFDAYIKD
910 920 930 940 950
MAKDSDYKFS LQFEELKLIG LDIPHFAADL PLNRCKNRYT NILPYDFSRV
960 970 980 990 1000
RLLSMNEEEG ADYINANYIP GYNSPQEYIA TQGPLPETRN DFWKMVLQQK
1010 1020 1030 1040 1050
SQMIVMLTQC NEKRRVKCDH YWPFTEEPIA YGDITVEMIS EEEQDDWAHR
1060 1070 1080 1090 1100
HFRINYADEM QDVMHFNYTA WPDHGVPTAN AAESILQFVH MVRQQATKSK
1110 1120 1130 1140 1150
GPMIIHCSAG VGRTGTFIAL DRLLQHIRDH EFVDILGLVS EMRSYRMSMV
1160 1170 1180
QTEEQYIFIH QCVQLMWMKK KQQFCISDVI YENVSKS
Length:1,187
Mass (Da):135,047
Last modified:November 1, 1996 - v1
Checksum:i68541F9A796A51B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09490 mRNA. Translation: AAA61709.1.
PIRiA53661.
RefSeqiNP_001076219.1. NM_001082750.1.
UniGeneiOcu.2018.

Genome annotation databases

GeneIDi100009529.
KEGGiocu:100009529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09490 mRNA. Translation: AAA61709.1.
PIRiA53661.
RefSeqiNP_001076219.1. NM_001082750.1.
UniGeneiOcu.2018.

3D structure databases

ProteinModelPortaliQ28613.
SMRiQ28613. Positions 887-1179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009529.
KEGGiocu:100009529.

Organism-specific databases

CTDi5800.

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115792.
HOVERGENiHBG053763.
KOiK18035.
OrthoDBiEOG7PCJFZ.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 5 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit."
    Thomas P.E., Wharram B.L., Goyal M., Wiggins J.E., Holzman L.B., Wiggins R.C.
    J. Biol. Chem. 269:19953-19962(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: New Zealand WhiteImported.
    Tissue: Renal glomerulusImported.

Entry informationi

Entry nameiQ28613_RABIT
AccessioniPrimary (citable) accession number: Q28613
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.