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Q28612

- UD14_RABIT

UniProt

Q28612 - UD14_RABIT

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Protein

UDP-glucuronosyltransferase 1-4

Gene

UGT1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-4 (EC:2.4.1.17)
Short name:
UDPGT 1-4
Short name:
UGT1*4
Short name:
UGT1-04
Short name:
UGT1.4
Alternative name(s):
UGT1A4
Gene namesi
Name:UGT1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei490 – 50617HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 532505UDP-glucuronosyltransferase 1-4PRO_0000036015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ28612.
SMRiQ28612. Positions 284-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ28612.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms may be produced. Isoforms may have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q28612-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLGVWITLW RLVRLLLLLC VLPWAEGGKV LVVPMDGSPW LSLREVVRDV
60 70 80 90 100
HARGHQVLVL GPEVTMHIKG EDFFTLQTYA TPYSKEEFDQ LMQRNYQMIF
110 120 130 140 150
KPQHSLKTLL ETMENLKKFS MLCSRSCWEL LHNKPLIKHL NESSFDVVLT
160 170 180 190 200
DPLDLCGALL AKYLSVPSVF LLRFILCDLD FEGTQCPNPS SYIPRMLTMN
210 220 230 240 250
SDHMSFLQRV KNMLYPLMMK YTCHISYDPY ASLASELFQR EVSLVDILSH
260 270 280 290 300
ASVWLFREDF VLDYPRPIMP NMVFIGGINC ANRKPLSQEF EAYVNASGEH
310 320 330 340 350
GIVVFSLGSM VSEIPEKKAM EIADALGKIP QTVLWRYTGS RPSNLAKNTY
360 370 380 390 400
LVKWLPQNVL LGHPKTRAFI THSGSHGIYE GICNGVPMVM LPLFGDQMDN
410 420 430 440 450
AKRIETRGAG VTLNVLEMTS DDLANALKTV INDKSYKENI MRLSSLHKDR
460 470 480 490 500
PVEPLDLAVF WVEFVMRHKG AAPRPAAHDL TWYQYHSLDV IGFLLAIVLT
510 520 530
VAFVTFKCCA FAWGKCFGKK GRVKKAHKSK VH
Length:532
Mass (Da):60,489
Last modified:November 1, 1997 - v1
Checksum:i2A594E81CC6EA672
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09101 mRNA. Translation: AAA51868.1.
RefSeqiNP_001082791.1. NM_001089322.1. [Q28612-1]
UniGeneiOcu.2010.

Genome annotation databases

GeneIDi100038310.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09101 mRNA. Translation: AAA51868.1 .
RefSeqi NP_001082791.1. NM_001089322.1. [Q28612-1 ]
UniGenei Ocu.2010.

3D structure databases

ProteinModelPortali Q28612.
SMRi Q28612. Positions 284-444.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100038310.

Organism-specific databases

CTDi 100038310.

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220832.
HOVERGENi HBG004033.
InParanoidi Q28612.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Philipp T., Durazzo M., Trautwein C., Alex B., Johnson E.F., Straub J.G., Straub P., Tukey R.H., Manns M.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiUD14_RABIT
AccessioniPrimary (citable) accession number: Q28612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3