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Q28612 (UD14_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-4

Short name=UDPGT 1-4
Short name=UGT1*4
Short name=UGT1-04
Short name=UGT1.4
EC=2.4.1.17
Alternative name(s):
UGT1A4
Gene names
Name:UGT1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms may have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q28612-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 532505UDP-glucuronosyltransferase 1-4
PRO_0000036015

Regions

Transmembrane490 – 50617Helical; Potential

Amino acid modifications

Glycosylation1411N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 2A594E81CC6EA672

FASTA53260,489
        10         20         30         40         50         60 
MVLGVWITLW RLVRLLLLLC VLPWAEGGKV LVVPMDGSPW LSLREVVRDV HARGHQVLVL 

        70         80         90        100        110        120 
GPEVTMHIKG EDFFTLQTYA TPYSKEEFDQ LMQRNYQMIF KPQHSLKTLL ETMENLKKFS 

       130        140        150        160        170        180 
MLCSRSCWEL LHNKPLIKHL NESSFDVVLT DPLDLCGALL AKYLSVPSVF LLRFILCDLD 

       190        200        210        220        230        240 
FEGTQCPNPS SYIPRMLTMN SDHMSFLQRV KNMLYPLMMK YTCHISYDPY ASLASELFQR 

       250        260        270        280        290        300 
EVSLVDILSH ASVWLFREDF VLDYPRPIMP NMVFIGGINC ANRKPLSQEF EAYVNASGEH 

       310        320        330        340        350        360 
GIVVFSLGSM VSEIPEKKAM EIADALGKIP QTVLWRYTGS RPSNLAKNTY LVKWLPQNVL 

       370        380        390        400        410        420 
LGHPKTRAFI THSGSHGIYE GICNGVPMVM LPLFGDQMDN AKRIETRGAG VTLNVLEMTS 

       430        440        450        460        470        480 
DDLANALKTV INDKSYKENI MRLSSLHKDR PVEPLDLAVF WVEFVMRHKG AAPRPAAHDL 

       490        500        510        520        530 
TWYQYHSLDV IGFLLAIVLT VAFVTFKCCA FAWGKCFGKK GRVKKAHKSK VH 

« Hide

References

[1]Philipp T., Durazzo M., Trautwein C., Alex B., Johnson E.F., Straub J.G., Straub P., Tukey R.H., Manns M.
Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09101 mRNA. Translation: AAA51868.1.
RefSeqNP_001082791.1. NM_001089322.1. [Q28612-1]
UniGeneOcu.2010.

3D structure databases

ProteinModelPortalQ28612.
SMRQ28612. Positions 284-444.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100038310.

Organism-specific databases

CTD100038310.

Phylogenomic databases

eggNOGCOG1819.
HOGENOMHOG000220832.
HOVERGENHBG004033.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD14_RABIT
AccessionPrimary (citable) accession number: Q28612
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families