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Q28612

- UD14_RABIT

UniProt

Q28612 - UD14_RABIT

Protein

UDP-glucuronosyltransferase 1-4

Gene

UGT1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-4 (EC:2.4.1.17)
    Short name:
    UDPGT 1-4
    Short name:
    UGT1*4
    Short name:
    UGT1-04
    Short name:
    UGT1.4
    Alternative name(s):
    UGT1A4
    Gene namesi
    Name:UGT1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 532505UDP-glucuronosyltransferase 1-4PRO_0000036015Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ28612.
    SMRiQ28612. Positions 284-444.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei490 – 50617HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms may be produced. Isoforms may have a different N-terminal domain and a common C-terminal domain of 245 residues.

    Isoform 1 (identifier: Q28612-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLGVWITLW RLVRLLLLLC VLPWAEGGKV LVVPMDGSPW LSLREVVRDV    50
    HARGHQVLVL GPEVTMHIKG EDFFTLQTYA TPYSKEEFDQ LMQRNYQMIF 100
    KPQHSLKTLL ETMENLKKFS MLCSRSCWEL LHNKPLIKHL NESSFDVVLT 150
    DPLDLCGALL AKYLSVPSVF LLRFILCDLD FEGTQCPNPS SYIPRMLTMN 200
    SDHMSFLQRV KNMLYPLMMK YTCHISYDPY ASLASELFQR EVSLVDILSH 250
    ASVWLFREDF VLDYPRPIMP NMVFIGGINC ANRKPLSQEF EAYVNASGEH 300
    GIVVFSLGSM VSEIPEKKAM EIADALGKIP QTVLWRYTGS RPSNLAKNTY 350
    LVKWLPQNVL LGHPKTRAFI THSGSHGIYE GICNGVPMVM LPLFGDQMDN 400
    AKRIETRGAG VTLNVLEMTS DDLANALKTV INDKSYKENI MRLSSLHKDR 450
    PVEPLDLAVF WVEFVMRHKG AAPRPAAHDL TWYQYHSLDV IGFLLAIVLT 500
    VAFVTFKCCA FAWGKCFGKK GRVKKAHKSK VH 532
    Length:532
    Mass (Da):60,489
    Last modified:November 1, 1997 - v1
    Checksum:i2A594E81CC6EA672
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09101 mRNA. Translation: AAA51868.1.
    RefSeqiNP_001082791.1. NM_001089322.1. [Q28612-1]
    UniGeneiOcu.2010.

    Genome annotation databases

    GeneIDi100038310.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09101 mRNA. Translation: AAA51868.1 .
    RefSeqi NP_001082791.1. NM_001089322.1. [Q28612-1 ]
    UniGenei Ocu.2010.

    3D structure databases

    ProteinModelPortali Q28612.
    SMRi Q28612. Positions 284-444.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100038310.

    Organism-specific databases

    CTDi 100038310.

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Philipp T., Durazzo M., Trautwein C., Alex B., Johnson E.F., Straub J.G., Straub P., Tukey R.H., Manns M.
      Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
      Tissue: Liver.

    Entry informationi

    Entry nameiUD14_RABIT
    AccessioniPrimary (citable) accession number: Q28612
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3