Reviewed, UniProtKB/Swiss-Prot Q28612 (UD14_RABIT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-4
      Short name=UDPGT
      Short name=UGT1*4
    EC=2.4.1.17
Alternative name(s):
    UGT1-04
      Short name=UGT1.4
    UGT1A4

Gene names

Name:

UGT1

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms may have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q28612-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 532	505	UDP-glucuronosyltransferase 1-4		PRO_0000036015
Regions
	Transmembrane	490 – 506	17	Potential
Amino acid modifications
	Glycosylation	141	1	N-linked (GlcNAc...) Potential
	Glycosylation	295	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 2A594E81CC6EA672	FASTA	532	60,489
	10 20 30 40 50 60 MVLGVWITLW RLVRLLLLLC VLPWAEGGKV LVVPMDGSPW LSLREVVRDV HARGHQVLVL 70 80 90 100 110 120 GPEVTMHIKG EDFFTLQTYA TPYSKEEFDQ LMQRNYQMIF KPQHSLKTLL ETMENLKKFS 130 140 150 160 170 180 MLCSRSCWEL LHNKPLIKHL NESSFDVVLT DPLDLCGALL AKYLSVPSVF LLRFILCDLD 190 200 210 220 230 240 FEGTQCPNPS SYIPRMLTMN SDHMSFLQRV KNMLYPLMMK YTCHISYDPY ASLASELFQR 250 260 270 280 290 300 EVSLVDILSH ASVWLFREDF VLDYPRPIMP NMVFIGGINC ANRKPLSQEF EAYVNASGEH 310 320 330 340 350 360 GIVVFSLGSM VSEIPEKKAM EIADALGKIP QTVLWRYTGS RPSNLAKNTY LVKWLPQNVL 370 380 390 400 410 420 LGHPKTRAFI THSGSHGIYE GICNGVPMVM LPLFGDQMDN AKRIETRGAG VTLNVLEMTS 430 440 450 460 470 480 DDLANALKTV INDKSYKENI MRLSSLHKDR PVEPLDLAVF WVEFVMRHKG AAPRPAAHDL 490 500 510 520 530 TWYQYHSLDV IGFLLAIVLT VAFVTFKCCA FAWGKCFGKK GRVKKAHKSK VH

References

[1]	Philipp T., Durazzo M., Trautwein C., Alex B., Johnson E.F., Straub J.G., Straub P., Tukey R.H., Manns M. Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: New Zealand white. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U09101 mRNA. Translation: AAA51868.1.
RefSeq	NP_001082791.1.
UniGene	Ocu.2010
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	ENSOCUG00000001570. Oryctolagus cuniculus. [Contig view]
GeneID	100038310.
Phylogenomic databases
HOVERGEN	Q28612.
Enzyme and pathway databases
BRENDA	2.4.1.17. 255.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UD14_RABIT

Accession

Primary (citable) accession number: Q28612

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)