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Q28611

- UD16_RABIT

UniProt

Q28611 - UD16_RABIT

Protein

UDP-glucuronosyltransferase 1-6

Gene

UGT1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-6 (EC:2.4.1.17)
    Short name:
    UDPGT 1-6
    Short name:
    UGT1*6
    Short name:
    UGT1-06
    Short name:
    UGT1.6
    Alternative name(s):
    UGT1A6
    Gene namesi
    Name:UGT1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 531505UDP-glucuronosyltransferase 1-6PRO_0000036018Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Inductioni

    By dioxin.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28611.
    SMRiQ28611. Positions 285-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei489 – 50517HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms may be produced. Isoforms may have a different N-terminal domain and a common C-terminal domain of 245 residues.

    Isoform 1 (identifier: Q28611-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MACLLSAAQR ASAGVLFVAL WGTVLGDRLL VVPQDGSHWL SMQDIVEALG    50
    ARGHEIVVLV PEVNLLLRES RFYTRRIYPV PFDQEEQSYR YRTFGEKHFT 100
    DRSWLSGPQT EYRNNMVVID MYFINCQSLL RHGDTLDFLR AGKFDALFTD 150
    PALPCGVILA EYLGLPSVYL FRGFPCSLEH GFGGSPNPVS YIPRCYTKFS 200
    DQMSFPQRVV NFLVNLLEVP LFYCLYSKYE DLAVELLKRE VDLPTLFQKD 250
    PVWLLRYDFV FEYPRPVMPN MVLIGGINCK KPDVLSQEFE AYVNASGEHG 300
    IVVFSLGSMV SEIPEKKAME IADALGKIPQ TVLWRYTGSR PSNLAKNTYL 350
    VKWLPQNVLL GHPKTRAFIT HSGSHGIYEG ICNGVPMVML PLFGDQMDNA 400
    KRIETRGAGV TLNVLEMTSD DLANALKTVI NDKSYKENIM RLSSLHKDRP 450
    VEPLDLAVFW VEFVMRHKGA APRPAAHDLT WYQYHSLDVI GFLLAIVLTV 500
    AFVTFKCCAF AWGKCFGKKG RVKKAHKSKV H 531
    Length:531
    Mass (Da):60,099
    Last modified:November 1, 1997 - v1
    Checksum:i872D317852F0928F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09030 mRNA. Translation: AAA51867.1.
    PIRiB55788.
    RefSeqiNP_001082788.1. NM_001089319.1. [Q28611-1]
    UniGeneiOcu.6910.

    Genome annotation databases

    GeneIDi100037718.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09030 mRNA. Translation: AAA51867.1 .
    PIRi B55788.
    RefSeqi NP_001082788.1. NM_001089319.1. [Q28611-1 ]
    UniGenei Ocu.6910.

    3D structure databases

    ProteinModelPortali Q28611.
    SMRi Q28611. Positions 285-443.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100037718.

    Organism-specific databases

    CTDi 100037718.

    Phylogenomic databases

    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
      Lamb J.G., Straub P., Tukey R.H.
      Biochemistry 33:10513-10520(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Strain: New Zealand white.
      Tissue: Liver.

    Entry informationi

    Entry nameiUD16_RABIT
    AccessioniPrimary (citable) accession number: Q28611
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3