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Protein

UDP-glucuronosyltransferase 1-6

Gene

UGT1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-6 (EC:2.4.1.17)
Short name:
UDPGT 1-6
Short name:
UGT1*6
Short name:
UGT1-06
Short name:
UGT1.6
Alternative name(s):
UGT1A6
Gene namesi
Name:UGT1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei489 – 505HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003601827 – 531UDP-glucuronosyltransferase 1-6Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ28611.

Expressioni

Inductioni

By dioxin.

Structurei

3D structure databases

ProteinModelPortaliQ28611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000220832.
HOVERGENiHBG004033.
KOiK00699.

Family and domain databases

InterProiView protein in InterPro
IPR002213. UDP_glucos_trans.
IPR035595. UDP_glycos_trans_CS.
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiView protein in Pfam
PF00201. UDPGT. 1 hit.
PROSITEiView protein in PROSITE
PS00375. UDPGT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced. Isoforms may have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q28611-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACLLSAAQR ASAGVLFVAL WGTVLGDRLL VVPQDGSHWL SMQDIVEALG
60 70 80 90 100
ARGHEIVVLV PEVNLLLRES RFYTRRIYPV PFDQEEQSYR YRTFGEKHFT
110 120 130 140 150
DRSWLSGPQT EYRNNMVVID MYFINCQSLL RHGDTLDFLR AGKFDALFTD
160 170 180 190 200
PALPCGVILA EYLGLPSVYL FRGFPCSLEH GFGGSPNPVS YIPRCYTKFS
210 220 230 240 250
DQMSFPQRVV NFLVNLLEVP LFYCLYSKYE DLAVELLKRE VDLPTLFQKD
260 270 280 290 300
PVWLLRYDFV FEYPRPVMPN MVLIGGINCK KPDVLSQEFE AYVNASGEHG
310 320 330 340 350
IVVFSLGSMV SEIPEKKAME IADALGKIPQ TVLWRYTGSR PSNLAKNTYL
360 370 380 390 400
VKWLPQNVLL GHPKTRAFIT HSGSHGIYEG ICNGVPMVML PLFGDQMDNA
410 420 430 440 450
KRIETRGAGV TLNVLEMTSD DLANALKTVI NDKSYKENIM RLSSLHKDRP
460 470 480 490 500
VEPLDLAVFW VEFVMRHKGA APRPAAHDLT WYQYHSLDVI GFLLAIVLTV
510 520 530
AFVTFKCCAF AWGKCFGKKG RVKKAHKSKV H
Length:531
Mass (Da):60,099
Last modified:November 1, 1997 - v1
Checksum:i872D317852F0928F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09030 mRNA. Translation: AAA51867.1.
PIRiB55788.
RefSeqiNP_001082788.1. NM_001089319.1. [Q28611-1]
UniGeneiOcu.6910.

Genome annotation databases

GeneIDi100037718.
KEGGiocu:100037718.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUD16_RABIT
AccessioniPrimary (citable) accession number: Q28611
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families