Reviewed, UniProtKB/Swiss-Prot Q28611 (UD16_RABIT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-6
      Short name=UDPGT
      Short name=UGT1*6
    EC=2.4.1.17
Alternative name(s):
    UGT1-06
      Short name=UGT1.6
    UGT1A6

Gene names

Name:

UGT1

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Induction	By dioxin.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms may have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q28611-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 531	505	UDP-glucuronosyltransferase 1-6		PRO_0000036018
Regions
	Transmembrane	489 – 505	17	Potential
Amino acid modifications
	Glycosylation	294	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 872D317852F0928F	FASTA	531	60,099
	10 20 30 40 50 60 MACLLSAAQR ASAGVLFVAL WGTVLGDRLL VVPQDGSHWL SMQDIVEALG ARGHEIVVLV 70 80 90 100 110 120 PEVNLLLRES RFYTRRIYPV PFDQEEQSYR YRTFGEKHFT DRSWLSGPQT EYRNNMVVID 130 140 150 160 170 180 MYFINCQSLL RHGDTLDFLR AGKFDALFTD PALPCGVILA EYLGLPSVYL FRGFPCSLEH 190 200 210 220 230 240 GFGGSPNPVS YIPRCYTKFS DQMSFPQRVV NFLVNLLEVP LFYCLYSKYE DLAVELLKRE 250 260 270 280 290 300 VDLPTLFQKD PVWLLRYDFV FEYPRPVMPN MVLIGGINCK KPDVLSQEFE AYVNASGEHG 310 320 330 340 350 360 IVVFSLGSMV SEIPEKKAME IADALGKIPQ TVLWRYTGSR PSNLAKNTYL VKWLPQNVLL 370 380 390 400 410 420 GHPKTRAFIT HSGSHGIYEG ICNGVPMVML PLFGDQMDNA KRIETRGAGV TLNVLEMTSD 430 440 450 460 470 480 DLANALKTVI NDKSYKENIM RLSSLHKDRP VEPLDLAVFW VEFVMRHKGA APRPAAHDLT 490 500 510 520 530 WYQYHSLDVI GFLLAIVLTV AFVTFKCCAF AWGKCFGKKG RVKKAHKSKV H

References

[1]

"Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Lamb J.G., Straub P., Tukey R.H. Biochemistry 33:10513-10520(1994) [PubMed: 8068691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Strain: New Zealand white. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U09030 mRNA. Translation: AAA51867.1.
PIR	B55788.
RefSeq	NP_001082788.1.
UniGene	Ocu.6910
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
GeneID	100037718.
Phylogenomic databases
HOVERGEN	Q28611.
Enzyme and pathway databases
BRENDA	2.4.1.17. 255.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UD16_RABIT

Accession

Primary (citable) accession number: Q28611

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)