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Q28611 (UD16_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-6

Short name=UDPGT 1-6
Short name=UGT1*6
Short name=UGT1-06
Short name=UGT1.6
EC=2.4.1.17
Alternative name(s):
UGT1A6
Gene names
Name:UGT1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Induction

By dioxin.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms may have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q28611-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 531505UDP-glucuronosyltransferase 1-6
PRO_0000036018

Regions

Transmembrane489 – 50517Helical; Potential

Amino acid modifications

Glycosylation2941N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 872D317852F0928F

FASTA53160,099
        10         20         30         40         50         60 
MACLLSAAQR ASAGVLFVAL WGTVLGDRLL VVPQDGSHWL SMQDIVEALG ARGHEIVVLV 

        70         80         90        100        110        120 
PEVNLLLRES RFYTRRIYPV PFDQEEQSYR YRTFGEKHFT DRSWLSGPQT EYRNNMVVID 

       130        140        150        160        170        180 
MYFINCQSLL RHGDTLDFLR AGKFDALFTD PALPCGVILA EYLGLPSVYL FRGFPCSLEH 

       190        200        210        220        230        240 
GFGGSPNPVS YIPRCYTKFS DQMSFPQRVV NFLVNLLEVP LFYCLYSKYE DLAVELLKRE 

       250        260        270        280        290        300 
VDLPTLFQKD PVWLLRYDFV FEYPRPVMPN MVLIGGINCK KPDVLSQEFE AYVNASGEHG 

       310        320        330        340        350        360 
IVVFSLGSMV SEIPEKKAME IADALGKIPQ TVLWRYTGSR PSNLAKNTYL VKWLPQNVLL 

       370        380        390        400        410        420 
GHPKTRAFIT HSGSHGIYEG ICNGVPMVML PLFGDQMDNA KRIETRGAGV TLNVLEMTSD 

       430        440        450        460        470        480 
DLANALKTVI NDKSYKENIM RLSSLHKDRP VEPLDLAVFW VEFVMRHKGA APRPAAHDLT 

       490        500        510        520        530 
WYQYHSLDVI GFLLAIVLTV AFVTFKCCAF AWGKCFGKKG RVKKAHKSKV H 

« Hide

References

[1]"Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
Lamb J.G., Straub P., Tukey R.H.
Biochemistry 33:10513-10520(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Strain: New Zealand white.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09030 mRNA. Translation: AAA51867.1.
PIRB55788.
RefSeqNP_001082788.1. NM_001089319.1. [Q28611-1]
UniGeneOcu.6910.

3D structure databases

ProteinModelPortalQ28611.
SMRQ28611. Positions 285-443.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100037718.

Organism-specific databases

CTD100037718.

Phylogenomic databases

HOGENOMHOG000220832.
HOVERGENHBG004033.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD16_RABIT
AccessionPrimary (citable) accession number: Q28611
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families