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Protein

Thyrotropin-releasing hormone receptor

Gene

TRHR

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
Gene namesi
Name:TRHR
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 9

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 5123Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini52 – 6110CytoplasmicSequence analysis
Transmembranei62 – 8322Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini84 – 9916ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12122Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini122 – 14423CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16824Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini169 – 19325ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21522Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 26651CytoplasmicSequence analysisAdd
BLAST
Transmembranei267 – 28822Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini289 – 2968ExtracellularSequence analysis
Transmembranei297 – 31923Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini320 – 39879CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Thyrotropin-releasing hormone receptorPRO_0000070190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi98 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ28596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00700000104070.
HOVERGENiHBG007549.
KOiK04282.
OMAiKLCNCKQ.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENETGSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV
60 70 80 90 100
MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC
110 120 130 140 150
ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW
160 170 180 190 200
AFTSIYCMLW FFLLDLNIST YKDAIVVSCG YKISRNYYSP IYLMDFGVFY
210 220 230 240 250
VVPMILATVL YGFIARILFL SPIPSDPKEN SNTWKNDSTH QNKNLNSKTS
260 270 280 290 300
NRYFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW
310 320 330 340 350
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PVEKPANYSV
360 370 380 390
ALNYSVIKES DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVTFSQS
Length:398
Mass (Da):45,089
Last modified:November 1, 1997 - v1
Checksum:i375A311D3DD2A61A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95285 mRNA. Translation: CAA64606.1.
RefSeqiNP_001009407.1. NM_001009407.1.
XP_012038762.1. XM_012183372.2.
UniGeneiOar.545.

Genome annotation databases

EnsembliENSOART00000015842; ENSOARP00000015611; ENSOARG00000014552.
GeneIDi443425.
KEGGioas:443425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95285 mRNA. Translation: CAA64606.1.
RefSeqiNP_001009407.1. NM_001009407.1.
XP_012038762.1. XM_012183372.2.
UniGeneiOar.545.

3D structure databases

ProteinModelPortaliQ28596.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000015842; ENSOARP00000015611; ENSOARG00000014552.
GeneIDi443425.
KEGGioas:443425.

Organism-specific databases

CTDi7201.

Phylogenomic databases

GeneTreeiENSGT00700000104070.
HOVERGENiHBG007549.
KOiK04282.
OMAiKLCNCKQ.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Thyrotropin expression in hypophyseal pars tuberalis-specific cells is 3,5,3'-triiodothyronine, thyrotropin-releasing hormone, and pit-1 independent."
    Bockmann J., Boeckers T.M., Winter C., Wittkowski W., Winterhoff H., Deufel T., Kreutz M.R.
    Endocrinology 138:1019-1028(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiTRFR_SHEEP
AccessioniPrimary (citable) accession number: Q28596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.