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Protein

Progonadoliberin-1

Gene

GNRH1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei3Appears to be essential for biological activity1

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: InterPro
  • regulation of follicle-stimulating hormone secretion Source: AgBase
  • regulation of luteinizing hormone secretion Source: AgBase

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
GnRH-associated peptide I
Gene namesi
Name:GNRH1
Synonyms:GNRH, LHRH
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000124131 – ›61Progonadoliberin-1Add BLAST›61
PeptideiPRO_00000124141 – 10Gonadoliberin-110
PeptideiPRO_000001241514 – ›61GnRH-associated peptide 1Add BLAST›48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Modified residuei10Glycine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Interactioni

GO - Molecular functioni

Structurei

Secondary structure

161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YY1NMR-A2-10[»]
SMRiQ28588.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ28588.

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
PANTHERiPTHR10522. PTHR10522. 1 hit.
PTHR10522:SF0. PTHR10522:SF0. 1 hit.
PfamiView protein in Pfam
PF00446. GnRH. 1 hit.
PRINTSiPR01541. GONADOLIBRNI.
PROSITEiView protein in PROSITE
PS00473. GNRH. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QHWSYGLRPG GKRNAKNVID SFQEIAKEVD QPVEPKCCGC IVHQSHSPLR
60
DLKAALESLI E
Length:61
Mass (Da):6,828
Last modified:December 15, 1998 - v2
Checksum:i63962A1AE319B8F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei611

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02517 mRNA. Translation: AAA03433.1.
PIRiA93780. RHSHG.
UniGeneiOar.657.

Entry informationi

Entry nameiGON1_SHEEP
AccessioniPrimary (citable) accession number: Q28588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: October 25, 2017
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families