Reviewed, UniProtKB/Swiss-Prot Q28560 (AVR2A_SHEEP)

Names and origin

Protein names

Recommended name:
    Activin receptor type-2A
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IIA
      Short name=ACTR-IIA

Gene names

Name:	ACVR2A
Synonyms:	ACTRII, ACVR2

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subunit structure	Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	activin receptor signaling pathway Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin receptor activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 513	494	Activin receptor type-2A		PRO_0000024400
Regions
	Topological domain	20 – 135	116	Extracellular Potential
	Transmembrane	136 – 161	26	Potential
	Topological domain	162 – 513	352	Cytoplasmic Potential
	Domain	192 – 485	294	Protein kinase
	Nucleotide binding	198 – 206	9	ATP By similarity
Sites
	Active site	322	1	Proton acceptor By similarity
	Binding site	219	1	ATP By similarity
Amino acid modifications
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Disulfide bond	30 ↔ 60		By similarity
	Disulfide bond	50 ↔ 78		By similarity
	Disulfide bond	85 ↔ 104		By similarity
	Disulfide bond	91 ↔ 103		By similarity
	Disulfide bond	105 ↔ 110		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q28560-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 7231BF9E85CA57E3	FASTA	513	57,768
	10 20 30 40 50 60 MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC 70 80 90 100 110 120 FATWKNISSS IDIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM 130 140 150 160 170 180 EVTQPTSNPV TPKPPYYNIL LYSLVPLMLV AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 190 200 210 220 230 240 PPPSPLLGLK PLQLLEVKAR GGFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 250 260 270 280 290 300 MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 310 320 330 340 350 360 AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 370 380 390 400 410 420 GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFVEEIG 430 440 450 460 470 480 QHPSLEDMQE VVVHKKKRPV LRDYWQKLAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 490 500 510 QMQRLTNIIT TEDIVTVVTV VTNVDFPPKE SSL

References

[1]	Tisdall D.J. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Romney. Tissue: Ovarian follicle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L19442 mRNA. Translation: AAA91903.1.
RefSeq	NP_001009293.1.
UniGene	Oar.414
3D structure databases
HSSP	HSSP built from PDB template 1BTE based on UniProtKB P27038.
SMR	Q28560. Positions 26-119.
ModBase	Search...
Genome annotation databases
GeneID	443304.
Phylogenomic databases
HOVERGEN	Q28560.
Enzyme and pathway databases
BRENDA	2.7.11.30. 271.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR015768. Activin_II_recpt_C. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
PANTHER	PTHR23255:SF10. Activin_II_recpt_C. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AVR2A_SHEEP

Accession

Primary (citable) accession number: Q28560

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)