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Q28560 (AVR2A_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activin receptor type-2A

EC=2.7.11.30
Alternative name(s):
Activin receptor type IIA
Short name=ACTR-IIA
Gene names
Name:ACVR2A
Synonyms:ACTRII, ACVR2
OrganismOvis aries (Sheep) [Reference proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subunit structure

Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 513494Activin receptor type-2A
PRO_0000024400

Regions

Topological domain20 – 135116Extracellular Potential
Transmembrane136 – 16126Helical; Potential
Topological domain162 – 513352Cytoplasmic Potential
Domain192 – 485294Protein kinase
Nucleotide binding198 – 2069ATP By similarity

Sites

Active site3221Proton acceptor By similarity
Binding site2191ATP By similarity

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 60 By similarity
Disulfide bond50 ↔ 78 By similarity
Disulfide bond85 ↔ 104 By similarity
Disulfide bond91 ↔ 103 By similarity
Disulfide bond105 ↔ 110 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28560 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 7231BF9E85CA57E3

FASTA51357,768
        10         20         30         40         50         60 
MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC 

        70         80         90        100        110        120 
FATWKNISSS IDIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM 

       130        140        150        160        170        180 
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLV AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 

       190        200        210        220        230        240 
PPPSPLLGLK PLQLLEVKAR GGFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 

       250        260        270        280        290        300 
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 

       310        320        330        340        350        360 
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 

       370        380        390        400        410        420 
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFVEEIG 

       430        440        450        460        470        480 
QHPSLEDMQE VVVHKKKRPV LRDYWQKLAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 

       490        500        510 
QMQRLTNIIT TEDIVTVVTV VTNVDFPPKE SSL 

« Hide

References

[1]Tisdall D.J.
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Romney.
Tissue: Ovarian follicle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19442 mRNA. Translation: AAA91903.1.
RefSeqNP_001009293.1. NM_001009293.1.
UniGeneOar.414.

3D structure databases

ProteinModelPortalQ28560.
SMRQ28560. Positions 26-119, 192-484.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443304.

Organism-specific databases

CTD92.

Phylogenomic databases

HOVERGENHBG054502.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAVR2A_SHEEP
AccessionPrimary (citable) accession number: Q28560
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families