Acetyl-CoA carboxylase 1 - Ovis aries (Sheep)

Names and origin

Protein names

Recommended name:
    Acetyl-CoA carboxylase 1
    EC=6.4.1.2
Alternative name(s):
    ACC-alpha
Including the following 1 domains:
    1- Recommended name:
            Biotin carboxylase
              EC=6.3.4.14

Gene names

Name:	ACACA
Synonyms:	ACAC

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

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Protein attributes

Sequence length	2346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Catalytic activity	ATP + acetyl-CoA + HCO₃^- = ADP + phosphate + malonyl-CoA. ATP + biotin-carboxyl-carrier protein + CO₂ = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.
Cofactor	Biotin By similarity. Binds 2 manganese ions per subunit By similarity.
Enzyme regulation	By phosphorylation By similarity.
Pathway	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
Subunit structure	Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Isoform 2 is expressed at high levels in mammary gland. Ref.2
Induction	Isoform 2 is induced in mammary gland during lactation. Ref.2
Post-translational modification	Phosphorylation on Ser-1263 is required for interaction with BRCA1 By similarity.
Sequence similarities	Contains 1 ATP-grasp domain. Contains 1 biotin carboxylation domain. Contains 1 biotinyl-binding domain. Contains 1 carboxyltransferase domain.

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Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Coding sequence diversity	Alternative promoter usage
Ligand	ATP-binding Biotin Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation Phosphoprotein
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetyl-CoA carboxylase activity Inferred from electronic annotation. Source: EC biotin binding Inferred from electronic annotation. Source: InterPro biotin carboxylase activity Inferred from electronic annotation. Source: EC manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative promoter usage. [Align] [Select]

Isoform 1 (identifier: Q28559-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q28559-2) Also known as: E5A; The sequence of this isoform differs from the canonical sequence as follows: 1-75: MGEPSSLAKP...SLQDGLALHM → MEGSAEESKEMRYYMLQ

Isoform 3 (identifier: Q28559-3) The sequence of this isoform differs from the canonical sequence as follows: 1-1: M → MWWSTLMSILRASSFWKWISAQTIRIIRALRARFEGTM

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2346

2346

Acetyl-CoA carboxylase 1

PRO_0000146766

Regions

Domain

117 – 618

502

Biotin carboxylation

Domain

275 – 466

192

ATP-grasp

Domain

752 – 818

67

Biotinyl-binding

Domain

1698 – 2194

497

Carboxyltransferase

Nucleotide binding

315 – 320

6

ATP Potential

Sites

Active site

441

1

By similarity

Metal binding

424

1

Manganese 1 By similarity

Metal binding

437

1

Manganese 1 By similarity

Metal binding

437

1

Manganese 2 By similarity

Metal binding

439

1

Manganese 2 By similarity

Binding site

1823

1

Coenzyme A By similarity

Binding site

2127

1

Coenzyme A By similarity

Binding site

2129

1

Coenzyme A By similarity

Amino acid modifications

Modified residue

1

N-acetylmethionine By similarity

Modified residue

5

1

Phosphoserine By similarity

Modified residue

23

1

Phosphoserine By similarity

Modified residue

25

1

Phosphoserine By similarity

Modified residue

29

1

Phosphoserine By similarity

Modified residue

48

1

Phosphoserine By similarity

Modified residue

50

1

Phosphoserine By similarity

Modified residue

53

1

Phosphoserine By similarity

Modified residue

56

1

Phosphoserine By similarity

Modified residue

58

1

Phosphothreonine By similarity

Modified residue

60

1

Phosphoserine By similarity

Modified residue

78

1

Phosphoserine By similarity

Modified residue

80

1

Phosphoserine By similarity

Modified residue

786

1

N6-biotinyllysine By similarity

Modified residue

1042

1

Phosphothreonine By similarity

Modified residue

1201

1

Phosphoserine By similarity

Modified residue

1263

1

Phosphoserine By similarity

Modified residue

1844

1

Phosphoserine By similarity

Modified residue

2108

1

Phosphotyrosine By similarity

Natural variations

Alternative sequence

1 – 75

75

MGEPS…LALHM → MEGSAEESKEMRYYMLQ in isoform 2.

VSP_026102

Alternative sequence

1

M → MWWSTLMSILRASSFWKWIS AQTIRIIRALRARFEGTM in isoform 3.

VSP_026103

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BCA010ADF6CD24EF Show »	FASTA	2,346	265,251
10 20 30 40 50 60 MGEPSSLAKP LELNQHSRFI IGSVSEDNSE DEISNLVKLD LLEEKEGSLS PASVSSDTLS 70 80 90 100 110 120 DLGISSLQDG LALHMRSSMS GLHLVKQGRD RKKIDSQRDF TVASPAEFVT RFGGNKVIEK 130 140 150 160 170 180 VLIANNGIAA VKCMRSIRRW SYEMFRNERA IRFVVMVTPE DLKANAEYIK MADHYVPVPG 190 200 210 220 230 240 GPNNNNYANV ELILDIARRI PVQAVWAGWG HASENPKLPE LLLKNGIAFM GPPSQAMWAL 250 260 270 280 290 300 GDKIASSIVA QTAGIPTLPW SGSGLCVDWH ENDFSKRILN VPQELYEKGY VKDVDDGLKA 310 320 330 340 350 360 AEEVGYPVMI KASEGGGGKG IRKVNNADDF PNLFRQVQAE VPGSPIFVMR LAKQSRHLEV 370 380 390 400 410 420 QILADQYGNA ISLFGRDCSV QRRHQKIIEE APAAIATPAV FEHMEQCAVK LARMVGYVSA 430 440 450 460 470 480 GTVEYLYSQD GSFYFLELNP RLQVEHPCTE MVADVNLPAA QLQIAMGIPL YRIKDIRMMY 490 500 510 520 530 540 GVSPWGDAPI DFENSAHVPC PRGHVIAARI TSENPDEGFK PSSGTVQELN FRSNKNVWGY 550 560 570 580 590 600 FSVAAAGGLH EFADSQFGHC FSWGENREEA ISNMVVALKE LSIRGDFRTT VEYLIKLLET 610 620 630 640 650 660 ESFQLNRIDT GWLDRLIAEK VQAERPDTML GVVCGALHVA DVSLRNSISN FLHSLERGQV 670 680 690 700 710 720 LSAHTLLNTV DVELIYEGEK IVLKVTRQSP NSYVVIMNGS CVEVDVHRLS DGGLLLSYDG 730 740 750 760 770 780 SSYTTYMKEE VDRYRITIGN KTCVFEKEND PSVLRSPSAG KLIQYIVEDG GHVFAGQCYA 790 800 810 820 830 840 EIEVMKMVMT LTAAESGCIH YVKRPGAALD PGCVIAKMQL DNPSKVQQAE LHTGSLPRIQ 850 860 870 880 890 900 STALRGEKLH RVFHYVLDNL VNVMNGYCLP DPFFSSRVKD WVEGLMKTLR DPSLPLLELQ 910 920 930 940 950 960 DIMTSVSGRI PPNVEKSIKK EMAQYASNIT SVLCQFPSQQ IANILDSHAA TLNRKSEREV 970 980 990 1000 1010 1020 FFMNTQSIVQ LVQRYRSGIR GHMKAVVMDL LRQYLRVETQ FQNGHYDKCV FALREENKSD 1030 1040 1050 1060 1070 1080 MNTVLNYIFS HAQVTKKNLL VTMLIDQLCG RDPTLTDELL NILTELTQLS KTTNAKVALR 1090 1100 1110 1120 1130 1140 ARQVLIASHL PSYELRHNQV ESIFLSAIDM YGHQFCIENL QKLILSETSI FDVLPNFFYH 1150 1160 1170 1180 1190 1200 SNQVVRMAAL EVYVRRAYIA YELNSVQHRQ LKDNTCVVEF QFMLPTSHPN RGNIPTLNRM 1210 1220 1230 1240 1250 1260 SFSSNLNHYG MTHVASVSDV LLDNAFTPPC QRMGGMVSFR TFEDFVRIFD EVMGCFCDSP 1270 1280 1290 1300 1310 1320 PQSPTFPEAG HTSLYDEDKV PRDEPIHILN VAIKTDCDIE DDSLAAMFRE FTQQNKATLV 1330 1340 1350 1360 1370 1380 EHGIRRLTFL VAQKDFRKQV NYEVDQRFHR EFPKFFTFRA RDKFEEDRIY RHLEPALAFQ 1390 1400 1410 1420 1430 1440 LELNRMRNFD LTAIPCANHK MHLYLGAAKV EVGTEVTDYR FFVRAIIRHS DLVTKEASFE 1450 1460 1470 1480 1490 1500 YLQNEGERLL LEAMDELEVA FNNTNVRTDC NHIFLNFVPT VIMDPSKIEE SVRSMVMRYG 1510 1520 1530 1540 1550 1560 SRLWKLRVLQ AELKINIRLT PTGKAIPIRL FLTNESGYYL DISLYKEVTD SRTAQIMFQA 1570 1580 1590 1600 1610 1620 YGDKQGPLHG MLINTPYVTK DLLQSKRFQA QSLGTTYIYD IPEMFRQSLI KLWESMSSQA 1630 1640 1650 1660 1670 1680 FLPPPPLPSD ILTYTELVLD DQGQLVHMNR LPGGNEIGMV AWKMTLKSPE YPDGRDIIVI 1690 1700 1710 1720 1730 1740 GNDITYRIGS FGPQEDLLFL RASELARAEG IPRIYVAANS GARIGLAEEI RHMFHVAWVD 1750 1760 1770 1780 1790 1800 PEDPYKGYKY LYLTPQDYKR VSALNSVHCE HVEDEGESRY KITDIIGKEE GLGAENLRGS 1810 1820 1830 1840 1850 1860 GMIAGESSLA YDEIITISLV TCRAIGIGAY LVRLGQRTIQ VENSHLILTG AGALNKVLGR 1870 1880 1890 1900 1910 1920 EVYTSNNQLG GIQIMHNNGV THSTVCDDFE GVFTVLHWLS YMPKSVYSSV PLLNSKDPID 1930 1940 1950 1960 1970 1980 RVIEFVPTKA PYDPRWMLAG RPHPTQKGQW LSGFFDYGSF SEIMQPWAQT VVVGRARLGG 1990 2000 2010 2020 2030 2040 IPVGVVAVET RTVELSIPAD PANLDSEAKI IQQAGQVWFP DSAFKTYQAI KDFNREGLPL 2050 2060 2070 2080 2090 2100 MVFANWRGFS GGMKDMYDQV LKFGAYIVDG LRECSQPVMV YIPPQAELRG GSWVVIDPTI 2110 2120 2130 2140 2150 2160 NPRHMEMYAD RESRGSVLEP EGTVEIKFRR KDLVKTMRRV DPVYIHLAER LGTPELSARE 2170 2180 2190 2200 2210 2220 RKELESKLKE REEFLLPIYH QVAVQFADLH DTPGRMQEKG VINDILDWKT SRTFFYWRLR 2230 2240 2250 2260 2270 2280 RLLLEDLVKK KIHNANPELT DGQIQAMLRR WFVEVEGTVK AYVWDNNKDL VEWLEKQLTE 2290 2300 2310 2320 2330 2340 EDGVRSVIEE NIKYISRDYV LKQIRSLVQA NPEVAMDSIV HMTQHISPTQ RAEVVRILST MDSPST « Hide
Isoform 2 (E5A). Checksum: 0B66EF366FC81E7E Show »	FASTA	2,288	259,351
10 20 30 40 50 60 MEGSAEESKE MRYYMLQRSS MSGLHLVKQG RDRKKIDSQR DFTVASPAEF VTRFGGNKVI 70 80 90 100 110 120 EKVLIANNGI AAVKCMRSIR RWSYEMFRNE RAIRFVVMVT PEDLKANAEY IKMADHYVPV 130 140 150 160 170 180 PGGPNNNNYA NVELILDIAR RIPVQAVWAG WGHASENPKL PELLLKNGIA FMGPPSQAMW 190 200 210 220 230 240 ALGDKIASSI VAQTAGIPTL PWSGSGLCVD WHENDFSKRI LNVPQELYEK GYVKDVDDGL 250 260 270 280 290 300 KAAEEVGYPV MIKASEGGGG KGIRKVNNAD DFPNLFRQVQ AEVPGSPIFV MRLAKQSRHL 310 320 330 340 350 360 EVQILADQYG NAISLFGRDC SVQRRHQKII EEAPAAIATP AVFEHMEQCA VKLARMVGYV 370 380 390 400 410 420 SAGTVEYLYS QDGSFYFLEL NPRLQVEHPC TEMVADVNLP AAQLQIAMGI PLYRIKDIRM 430 440 450 460 470 480 MYGVSPWGDA PIDFENSAHV PCPRGHVIAA RITSENPDEG FKPSSGTVQE LNFRSNKNVW 490 500 510 520 530 540 GYFSVAAAGG LHEFADSQFG HCFSWGENRE EAISNMVVAL KELSIRGDFR TTVEYLIKLL 550 560 570 580 590 600 ETESFQLNRI DTGWLDRLIA EKVQAERPDT MLGVVCGALH VADVSLRNSI SNFLHSLERG 610 620 630 640 650 660 QVLSAHTLLN TVDVELIYEG EKIVLKVTRQ SPNSYVVIMN GSCVEVDVHR LSDGGLLLSY 670 680 690 700 710 720 DGSSYTTYMK EEVDRYRITI GNKTCVFEKE NDPSVLRSPS AGKLIQYIVE DGGHVFAGQC 730 740 750 760 770 780 YAEIEVMKMV MTLTAAESGC IHYVKRPGAA LDPGCVIAKM QLDNPSKVQQ AELHTGSLPR 790 800 810 820 830 840 IQSTALRGEK LHRVFHYVLD NLVNVMNGYC LPDPFFSSRV KDWVEGLMKT LRDPSLPLLE 850 860 870 880 890 900 LQDIMTSVSG RIPPNVEKSI KKEMAQYASN ITSVLCQFPS QQIANILDSH AATLNRKSER 910 920 930 940 950 960 EVFFMNTQSI VQLVQRYRSG IRGHMKAVVM DLLRQYLRVE TQFQNGHYDK CVFALREENK 970 980 990 1000 1010 1020 SDMNTVLNYI FSHAQVTKKN LLVTMLIDQL CGRDPTLTDE LLNILTELTQ LSKTTNAKVA 1030 1040 1050 1060 1070 1080 LRARQVLIAS HLPSYELRHN QVESIFLSAI DMYGHQFCIE NLQKLILSET SIFDVLPNFF 1090 1100 1110 1120 1130 1140 YHSNQVVRMA ALEVYVRRAY IAYELNSVQH RQLKDNTCVV EFQFMLPTSH PNRGNIPTLN 1150 1160 1170 1180 1190 1200 RMSFSSNLNH YGMTHVASVS DVLLDNAFTP PCQRMGGMVS FRTFEDFVRI FDEVMGCFCD 1210 1220 1230 1240 1250 1260 SPPQSPTFPE AGHTSLYDED KVPRDEPIHI LNVAIKTDCD IEDDSLAAMF REFTQQNKAT 1270 1280 1290 1300 1310 1320 LVEHGIRRLT FLVAQKDFRK QVNYEVDQRF HREFPKFFTF RARDKFEEDR IYRHLEPALA 1330 1340 1350 1360 1370 1380 FQLELNRMRN FDLTAIPCAN HKMHLYLGAA KVEVGTEVTD YRFFVRAIIR HSDLVTKEAS 1390 1400 1410 1420 1430 1440 FEYLQNEGER LLLEAMDELE VAFNNTNVRT DCNHIFLNFV PTVIMDPSKI EESVRSMVMR 1450 1460 1470 1480 1490 1500 YGSRLWKLRV LQAELKINIR LTPTGKAIPI RLFLTNESGY YLDISLYKEV TDSRTAQIMF 1510 1520 1530 1540 1550 1560 QAYGDKQGPL HGMLINTPYV TKDLLQSKRF QAQSLGTTYI YDIPEMFRQS LIKLWESMSS 1570 1580 1590 1600 1610 1620 QAFLPPPPLP SDILTYTELV LDDQGQLVHM NRLPGGNEIG MVAWKMTLKS PEYPDGRDII 1630 1640 1650 1660 1670 1680 VIGNDITYRI GSFGPQEDLL FLRASELARA EGIPRIYVAA NSGARIGLAE EIRHMFHVAW 1690 1700 1710 1720 1730 1740 VDPEDPYKGY KYLYLTPQDY KRVSALNSVH CEHVEDEGES RYKITDIIGK EEGLGAENLR 1750 1760 1770 1780 1790 1800 GSGMIAGESS LAYDEIITIS LVTCRAIGIG AYLVRLGQRT IQVENSHLIL TGAGALNKVL 1810 1820 1830 1840 1850 1860 GREVYTSNNQ LGGIQIMHNN GVTHSTVCDD FEGVFTVLHW LSYMPKSVYS SVPLLNSKDP 1870 1880 1890 1900 1910 1920 IDRVIEFVPT KAPYDPRWML AGRPHPTQKG QWLSGFFDYG SFSEIMQPWA QTVVVGRARL 1930 1940 1950 1960 1970 1980 GGIPVGVVAV ETRTVELSIP ADPANLDSEA KIIQQAGQVW FPDSAFKTYQ AIKDFNREGL 1990 2000 2010 2020 2030 2040 PLMVFANWRG FSGGMKDMYD QVLKFGAYIV DGLRECSQPV MVYIPPQAEL RGGSWVVIDP 2050 2060 2070 2080 2090 2100 TINPRHMEMY ADRESRGSVL EPEGTVEIKF RRKDLVKTMR RVDPVYIHLA ERLGTPELSA 2110 2120 2130 2140 2150 2160 RERKELESKL KEREEFLLPI YHQVAVQFAD LHDTPGRMQE KGVINDILDW KTSRTFFYWR 2170 2180 2190 2200 2210 2220 LRRLLLEDLV KKKIHNANPE LTDGQIQAML RRWFVEVEGT VKAYVWDNNK DLVEWLEKQL 2230 2240 2250 2260 2270 2280 TEEDGVRSVI EENIKYISRD YVLKQIRSLV QANPEVAMDS IVHMTQHISP TQRAEVVRIL STMDSPST « Hide
Isoform 3. Checksum: C697CD9E0D5243C9 Show »	FASTA	2,383	269,705
10 20 30 40 50 60 MWWSTLMSIL RASSFWKWIS AQTIRIIRAL RARFEGTMGE PSSLAKPLEL NQHSRFIIGS 70 80 90 100 110 120 VSEDNSEDEI SNLVKLDLLE EKEGSLSPAS VSSDTLSDLG ISSLQDGLAL HMRSSMSGLH 130 140 150 160 170 180 LVKQGRDRKK IDSQRDFTVA SPAEFVTRFG GNKVIEKVLI ANNGIAAVKC MRSIRRWSYE 190 200 210 220 230 240 MFRNERAIRF VVMVTPEDLK ANAEYIKMAD HYVPVPGGPN NNNYANVELI LDIARRIPVQ 250 260 270 280 290 300 AVWAGWGHAS ENPKLPELLL KNGIAFMGPP SQAMWALGDK IASSIVAQTA GIPTLPWSGS 310 320 330 340 350 360 GLCVDWHEND FSKRILNVPQ ELYEKGYVKD VDDGLKAAEE VGYPVMIKAS EGGGGKGIRK 370 380 390 400 410 420 VNNADDFPNL FRQVQAEVPG SPIFVMRLAK QSRHLEVQIL ADQYGNAISL FGRDCSVQRR 430 440 450 460 470 480 HQKIIEEAPA AIATPAVFEH MEQCAVKLAR MVGYVSAGTV EYLYSQDGSF YFLELNPRLQ 490 500 510 520 530 540 VEHPCTEMVA DVNLPAAQLQ IAMGIPLYRI KDIRMMYGVS PWGDAPIDFE NSAHVPCPRG 550 560 570 580 590 600 HVIAARITSE NPDEGFKPSS GTVQELNFRS NKNVWGYFSV AAAGGLHEFA DSQFGHCFSW 610 620 630 640 650 660 GENREEAISN MVVALKELSI RGDFRTTVEY LIKLLETESF QLNRIDTGWL DRLIAEKVQA 670 680 690 700 710 720 ERPDTMLGVV CGALHVADVS LRNSISNFLH SLERGQVLSA HTLLNTVDVE LIYEGEKIVL 730 740 750 760 770 780 KVTRQSPNSY VVIMNGSCVE VDVHRLSDGG LLLSYDGSSY TTYMKEEVDR YRITIGNKTC 790 800 810 820 830 840 VFEKENDPSV LRSPSAGKLI QYIVEDGGHV FAGQCYAEIE VMKMVMTLTA AESGCIHYVK 850 860 870 880 890 900 RPGAALDPGC VIAKMQLDNP SKVQQAELHT GSLPRIQSTA LRGEKLHRVF HYVLDNLVNV 910 920 930 940 950 960 MNGYCLPDPF FSSRVKDWVE GLMKTLRDPS LPLLELQDIM TSVSGRIPPN VEKSIKKEMA 970 980 990 1000 1010 1020 QYASNITSVL CQFPSQQIAN ILDSHAATLN RKSEREVFFM NTQSIVQLVQ RYRSGIRGHM 1030 1040 1050 1060 1070 1080 KAVVMDLLRQ YLRVETQFQN GHYDKCVFAL REENKSDMNT VLNYIFSHAQ VTKKNLLVTM 1090 1100 1110 1120 1130 1140 LIDQLCGRDP TLTDELLNIL TELTQLSKTT NAKVALRARQ VLIASHLPSY ELRHNQVESI 1150 1160 1170 1180 1190 1200 FLSAIDMYGH QFCIENLQKL ILSETSIFDV LPNFFYHSNQ VVRMAALEVY VRRAYIAYEL 1210 1220 1230 1240 1250 1260 NSVQHRQLKD NTCVVEFQFM LPTSHPNRGN IPTLNRMSFS SNLNHYGMTH VASVSDVLLD 1270 1280 1290 1300 1310 1320 NAFTPPCQRM GGMVSFRTFE DFVRIFDEVM GCFCDSPPQS PTFPEAGHTS LYDEDKVPRD 1330 1340 1350 1360 1370 1380 EPIHILNVAI KTDCDIEDDS LAAMFREFTQ QNKATLVEHG IRRLTFLVAQ KDFRKQVNYE 1390 1400 1410 1420 1430 1440 VDQRFHREFP KFFTFRARDK FEEDRIYRHL EPALAFQLEL NRMRNFDLTA IPCANHKMHL 1450 1460 1470 1480 1490 1500 YLGAAKVEVG TEVTDYRFFV RAIIRHSDLV TKEASFEYLQ NEGERLLLEA MDELEVAFNN 1510 1520 1530 1540 1550 1560 TNVRTDCNHI FLNFVPTVIM DPSKIEESVR SMVMRYGSRL WKLRVLQAEL KINIRLTPTG 1570 1580 1590 1600 1610 1620 KAIPIRLFLT NESGYYLDIS LYKEVTDSRT AQIMFQAYGD KQGPLHGMLI NTPYVTKDLL 1630 1640 1650 1660 1670 1680 QSKRFQAQSL GTTYIYDIPE MFRQSLIKLW ESMSSQAFLP PPPLPSDILT YTELVLDDQG 1690 1700 1710 1720 1730 1740 QLVHMNRLPG GNEIGMVAWK MTLKSPEYPD GRDIIVIGND ITYRIGSFGP QEDLLFLRAS 1750 1760 1770 1780 1790 1800 ELARAEGIPR IYVAANSGAR IGLAEEIRHM FHVAWVDPED PYKGYKYLYL TPQDYKRVSA 1810 1820 1830 1840 1850 1860 LNSVHCEHVE DEGESRYKIT DIIGKEEGLG AENLRGSGMI AGESSLAYDE IITISLVTCR 1870 1880 1890 1900 1910 1920 AIGIGAYLVR LGQRTIQVEN SHLILTGAGA LNKVLGREVY TSNNQLGGIQ IMHNNGVTHS 1930 1940 1950 1960 1970 1980 TVCDDFEGVF TVLHWLSYMP KSVYSSVPLL NSKDPIDRVI EFVPTKAPYD PRWMLAGRPH 1990 2000 2010 2020 2030 2040 PTQKGQWLSG FFDYGSFSEI MQPWAQTVVV GRARLGGIPV GVVAVETRTV ELSIPADPAN 2050 2060 2070 2080 2090 2100 LDSEAKIIQQ AGQVWFPDSA FKTYQAIKDF NREGLPLMVF ANWRGFSGGM KDMYDQVLKF 2110 2120 2130 2140 2150 2160 GAYIVDGLRE CSQPVMVYIP PQAELRGGSW VVIDPTINPR HMEMYADRES RGSVLEPEGT 2170 2180 2190 2200 2210 2220 VEIKFRRKDL VKTMRRVDPV YIHLAERLGT PELSARERKE LESKLKEREE FLLPIYHQVA 2230 2240 2250 2260 2270 2280 VQFADLHDTP GRMQEKGVIN DILDWKTSRT FFYWRLRRLL LEDLVKKKIH NANPELTDGQ 2290 2300 2310 2320 2330 2340 IQAMLRRWFV EVEGTVKAYV WDNNKDLVEW LEKQLTEEDG VRSVIEENIK YISRDYVLKQ 2350 2360 2370 2380 IRSLVQANPE VAMDSIVHMT QHISPTQRAE VVRILSTMDS PST « Hide

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References

[1]	"Cloning and characterisation of multiple acetyl-CoA carboxylase transcripts in ovine adipose tissue." Barber M.C., Travers M.T. Gene 154:271-275(1995) [PubMed: 7890176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: Finn-Dorset. Tissue: Adipose tissue.
[2]	"Elucidation of a promoter activity that directs the expression of acetyl-CoA carboxylase alpha with an alternative N-terminus in a tissue-restricted fashion." Barber M.C., Travers M.T. Biochem. J. 333:17-25(1998) [PubMed: 9639557] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-144 (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION BY LACTATION. Strain: Finn-Dorset. Tissue: Mammary gland.
[3]	"Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes." Travers M.T., Cambot M., Kennedy H.T., Lenoir G.M., Barber M.C., Joulin V. Genomics 85:71-84(2005) [PubMed: 15607423] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-93 (ISOFORM 3). Tissue: Brain.

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Cross-references

Sequence databases
	X80045 mRNA. Translation: CAA56352.1. AJ001056 mRNA. Translation: CAA04506.1. AJ564445 mRNA. Translation: CAD92090.1.
RefSeq	NP_001009256.1.
UniGene	Oar.17311 Oar.994
3D structure databases
HSSP	HSSP built from PDB template 1OD4 based on UniProtKB Q00955.
ModBase	Search...
Genome annotation databases
GeneID	443186.
Phylogenomic databases
HOVERGEN	Q28559.
Enzyme and pathway databases
BRENDA	6.3.4.14. 271. 6.4.1.2. 271.
Family and domain databases
InterPro	IPR013537. AcCoA_COase_cen. IPR011761. ATP-grasp. IPR013816. ATP_grasp_subdomain_2. IPR011764. BC. IPR001882. Biotin_BS. IPR005482. Biotin_COase_C. IPR000089. Biotin_lipoyl. IPR005479. CarbamoylP_synth_lsu_ATP-bd. IPR005481. CarbamoylP_synth_lsu_N. IPR000022. Carboxyl_trans. IPR011763. COA_CT_C. IPR011762. COA_CT_N. IPR013817. Pre-ATP_grasp. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
Pfam	PF08326. ACC_central. 1 hit. PF02785. Biotin_carb_C. 1 hit. PF00364. Biotin_lipoyl. 1 hit. PF01039. Carboxyl_trans. 1 hit. PF00289. CPSase_L_chain. 1 hit. PF02786. CPSase_L_D2. 1 hit. [Graphical view]
PROSITE	PS50975. ATP_GRASP. 1 hit. PS50979. BC. 1 hit. PS00188. BIOTIN. 1 hit. PS50968. BIOTINYL_LIPOYL. 1 hit. PS50989. COA_CT_CTER. 1 hit. PS50980. COA_CT_NTER. 1 hit. PS00866. CPSASE_1. 1 hit. PS00867. CPSASE_2. 1 hit. [Graphical view]
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Entry information

Entry name

ACACA_SHEEP

Accession

Primary (citable) accession number: Q28559
Secondary accession number(s): O62847, Q6KEV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents