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Protein

Serum albumin

Gene

ALB

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19CopperBy similarity1
Metal bindingi83ZincBy similarity1
Metal bindingi115ZincBy similarity1
Binding sitei256BilirubinBy similarity1
Metal bindingi263ZincBy similarity1
Metal bindingi265ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 10By similarity›10
PropeptideiPRO_000000106911 – 16By similarity6
ChainiPRO_000000107017 – 600Serum albuminAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Disulfide bondi69 ↔ 78PROSITE-ProRule annotation
Modified residuei74PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1
Disulfide bondi91 ↔ 107PROSITE-ProRule annotation
Modified residuei99PhosphothreonineBy similarity1
Disulfide bondi106 ↔ 117PROSITE-ProRule annotation
Disulfide bondi140 ↔ 185PROSITE-ProRule annotation
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi216 ↔ 262PROSITE-ProRule annotation
Modified residuei221N6-succinyllysineBy similarity1
Disulfide bondi261 ↔ 269PROSITE-ProRule annotation
Disulfide bondi281 ↔ 295PROSITE-ProRule annotation
Modified residuei289PhosphoserineBy similarity1
Disulfide bondi294 ↔ 305PROSITE-ProRule annotation
Disulfide bondi332 ↔ 377PROSITE-ProRule annotation
Disulfide bondi376 ↔ 385PROSITE-ProRule annotation
Disulfide bondi408 ↔ 454PROSITE-ProRule annotation
Modified residuei435PhosphoserineBy similarity1
Modified residuei436PhosphothreonineBy similarity1
Modified residuei438PhosphothreonineBy similarity1
Modified residuei452N6-succinyllysineBy similarity1
Disulfide bondi453 ↔ 464PROSITE-ProRule annotation
Disulfide bondi477 ↔ 493PROSITE-ProRule annotation
Disulfide bondi492 ↔ 503PROSITE-ProRule annotation
Modified residuei505PhosphoserineBy similarity1
Disulfide bondi530 ↔ 575PROSITE-ProRule annotation
Modified residuei535N6-succinyllysineBy similarity1
Modified residuei550N6-methyllysineBy similarity1
Disulfide bondi574 ↔ 583PROSITE-ProRule annotation
Modified residuei580N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PRIDEiQ28522

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005100

Structurei

3D structure databases

ProteinModelPortaliQ28522
SMRiQ28522
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 202Albumin 1PROSITE-ProRule annotationAdd BLAST192
Domaini203 – 395Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini396 – 593Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiQ28522
KOiK16141

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLFLFSSAYS RGVFRRDTHK SEVAHRFKDL GEEHFKGLVL VAFSQYLQQC
60 70 80 90 100
PFEEHVKLVN EVTEFAKTCV ADESAENCDK SLHTLFGDKL CTVATLRETY
110 120 130 140 150
GEMADCCAKQ EPERNECFLQ HKDDNPNLPP LVRPEVDVMC TAFHDNEATF
160 170 180 190 200
LKKYLYEVAR RHPYFYAPEL LFFAARYKAA FAECCQAADK AACLLPKLDE
210 220 230 240 250
LRDEGKASSA KQRLKCASLQ KFGDRAFKAW AVARLSQKFP KAEFAEVSKL
260 270 280 290 300
VTDLTKVHTE CCHGDLLECA DDRADLAKYM CENQDSISSK LKECCDKPLL
310 320 330 340 350
EKSHCLAEVE NDEMPADLPS LAADYVESKD VCKNYAEAKD VFLGMFLYEY
360 370 380 390 400
ARRHPDYSVM LLLRLAKAYE ATLEKCCAAA DPHECYAKVF DEFQPLVEEP
410 420 430 440 450
QNLVKQNCEL FEQLGEYKFQ NALLVRYTKK VPQVSTPTLV EVSRNLGKVG
460 470 480 490 500
AKCCKLPEAK RMPCAEDYLS VVLNRLCVLH EKTPVSEKVT KCCTESLVNR
510 520 530 540 550
RPCFSALELD EAYVPKAFNA ETFTFHADMC TLSEKEKQVK KQTALVELVK
560 570 580 590 600
HKPKATKEQL KGVMDNFAAF VEKCCKADDK EACFAEEGPK FVAASQAALA
Length:600
Mass (Da):67,881
Last modified:November 1, 1996 - v1
Checksum:iE45C871A670E740B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90463 mRNA Translation: AAA36906.1
PIRiA47391
RefSeqiNP_001182578.1, NM_001195649.1
UniGeneiMmu.2987

Genome annotation databases

GeneIDi704892
KEGGimcc:704892

Similar proteinsi

Entry informationi

Entry nameiALBU_MACMU
AccessioniPrimary (citable) accession number: Q28522
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome