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Protein

Serum albumin

Gene

ALB

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19CopperBy similarity1
Metal bindingi83ZincBy similarity1
Metal bindingi115ZincBy similarity1
Binding sitei256BilirubinBy similarity1
Metal bindingi263ZincBy similarity1
Metal bindingi265ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 10By similarity›10
PropeptideiPRO_000000106911 – 16By similarity6
ChainiPRO_000000107017 – 600Serum albuminAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Disulfide bondi69 ↔ 78PROSITE-ProRule annotation
Modified residuei74PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1
Disulfide bondi91 ↔ 107PROSITE-ProRule annotation
Modified residuei99PhosphothreonineBy similarity1
Disulfide bondi106 ↔ 117PROSITE-ProRule annotation
Disulfide bondi140 ↔ 185PROSITE-ProRule annotation
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi216 ↔ 262PROSITE-ProRule annotation
Modified residuei221N6-succinyllysineBy similarity1
Disulfide bondi261 ↔ 269PROSITE-ProRule annotation
Disulfide bondi281 ↔ 295PROSITE-ProRule annotation
Modified residuei289PhosphoserineBy similarity1
Disulfide bondi294 ↔ 305PROSITE-ProRule annotation
Disulfide bondi332 ↔ 377PROSITE-ProRule annotation
Disulfide bondi376 ↔ 385PROSITE-ProRule annotation
Disulfide bondi408 ↔ 454PROSITE-ProRule annotation
Modified residuei435PhosphoserineBy similarity1
Modified residuei436PhosphothreonineBy similarity1
Modified residuei438PhosphothreonineBy similarity1
Modified residuei452N6-succinyllysineBy similarity1
Disulfide bondi453 ↔ 464PROSITE-ProRule annotation
Disulfide bondi477 ↔ 493PROSITE-ProRule annotation
Disulfide bondi492 ↔ 503PROSITE-ProRule annotation
Modified residuei505PhosphoserineBy similarity1
Disulfide bondi530 ↔ 575PROSITE-ProRule annotation
Modified residuei535N6-succinyllysineBy similarity1
Modified residuei550N6-methyllysineBy similarity1
Disulfide bondi574 ↔ 583PROSITE-ProRule annotation
Modified residuei580N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PRIDEiQ28522.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSMMUG00000003827.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005100.

Structurei

3D structure databases

ProteinModelPortaliQ28522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 202Albumin 1PROSITE-ProRule annotationAdd BLAST192
Domaini203 – 395Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini396 – 593Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiQ28522.
KOiK16141.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLFLFSSAYS RGVFRRDTHK SEVAHRFKDL GEEHFKGLVL VAFSQYLQQC
60 70 80 90 100
PFEEHVKLVN EVTEFAKTCV ADESAENCDK SLHTLFGDKL CTVATLRETY
110 120 130 140 150
GEMADCCAKQ EPERNECFLQ HKDDNPNLPP LVRPEVDVMC TAFHDNEATF
160 170 180 190 200
LKKYLYEVAR RHPYFYAPEL LFFAARYKAA FAECCQAADK AACLLPKLDE
210 220 230 240 250
LRDEGKASSA KQRLKCASLQ KFGDRAFKAW AVARLSQKFP KAEFAEVSKL
260 270 280 290 300
VTDLTKVHTE CCHGDLLECA DDRADLAKYM CENQDSISSK LKECCDKPLL
310 320 330 340 350
EKSHCLAEVE NDEMPADLPS LAADYVESKD VCKNYAEAKD VFLGMFLYEY
360 370 380 390 400
ARRHPDYSVM LLLRLAKAYE ATLEKCCAAA DPHECYAKVF DEFQPLVEEP
410 420 430 440 450
QNLVKQNCEL FEQLGEYKFQ NALLVRYTKK VPQVSTPTLV EVSRNLGKVG
460 470 480 490 500
AKCCKLPEAK RMPCAEDYLS VVLNRLCVLH EKTPVSEKVT KCCTESLVNR
510 520 530 540 550
RPCFSALELD EAYVPKAFNA ETFTFHADMC TLSEKEKQVK KQTALVELVK
560 570 580 590 600
HKPKATKEQL KGVMDNFAAF VEKCCKADDK EACFAEEGPK FVAASQAALA
Length:600
Mass (Da):67,881
Last modified:November 1, 1996 - v1
Checksum:iE45C871A670E740B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90463 mRNA. Translation: AAA36906.1.
PIRiA47391.
RefSeqiNP_001182578.1. NM_001195649.1.
UniGeneiMmu.2987.

Genome annotation databases

GeneIDi704892.
KEGGimcc:704892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90463 mRNA. Translation: AAA36906.1.
PIRiA47391.
RefSeqiNP_001182578.1. NM_001195649.1.
UniGeneiMmu.2987.

3D structure databases

ProteinModelPortaliQ28522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005100.

Proteomic databases

PRIDEiQ28522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi704892.
KEGGimcc:704892.

Organism-specific databases

CTDi213.

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiQ28522.
KOiK16141.

Gene expression databases

BgeeiENSMMUG00000003827.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALBU_MACMU
AccessioniPrimary (citable) accession number: Q28522
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.