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Protein

Serum albumin

Gene

ALB

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191CopperBy similarity
Metal bindingi83 – 831ZincBy similarity
Metal bindingi115 – 1151ZincBy similarity
Binding sitei256 – 2561BilirubinBy similarity
Metal bindingi263 – 2631ZincBy similarity
Metal bindingi265 – 2651ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 10›10By similarity
Propeptidei11 – 166By similarityPRO_0000001069
Chaini17 – 600584Serum albuminPRO_0000001070Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineBy similarity
Disulfide bondi69 ↔ 78PROSITE-ProRule annotation
Modified residuei74 – 741PhosphoserineBy similarity
Modified residuei81 – 811PhosphoserineBy similarity
Disulfide bondi91 ↔ 107PROSITE-ProRule annotation
Modified residuei99 – 991PhosphothreonineBy similarity
Disulfide bondi106 ↔ 117PROSITE-ProRule annotation
Disulfide bondi140 ↔ 185PROSITE-ProRule annotation
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi216 ↔ 262PROSITE-ProRule annotation
Modified residuei221 – 2211N6-succinyllysineBy similarity
Disulfide bondi261 ↔ 269PROSITE-ProRule annotation
Disulfide bondi281 ↔ 295PROSITE-ProRule annotation
Modified residuei289 – 2891PhosphoserineBy similarity
Disulfide bondi294 ↔ 305PROSITE-ProRule annotation
Disulfide bondi332 ↔ 377PROSITE-ProRule annotation
Disulfide bondi376 ↔ 385PROSITE-ProRule annotation
Disulfide bondi408 ↔ 454PROSITE-ProRule annotation
Modified residuei435 – 4351PhosphoserineBy similarity
Modified residuei436 – 4361PhosphothreonineBy similarity
Modified residuei438 – 4381PhosphothreonineBy similarity
Modified residuei452 – 4521N6-succinyllysineBy similarity
Disulfide bondi453 ↔ 464PROSITE-ProRule annotation
Disulfide bondi477 ↔ 493PROSITE-ProRule annotation
Disulfide bondi492 ↔ 503PROSITE-ProRule annotation
Modified residuei505 – 5051PhosphoserineBy similarity
Disulfide bondi530 ↔ 575PROSITE-ProRule annotation
Modified residuei535 – 5351N6-succinyllysineBy similarity
Disulfide bondi574 ↔ 583PROSITE-ProRule annotation
Modified residuei580 – 5801N6-succinyllysineBy similarity

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005100.

Structurei

3D structure databases

ProteinModelPortaliQ28522.
SMRiQ28522. Positions 21-577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 202192Albumin 1PROSITE-ProRule annotationAdd
BLAST
Domaini203 – 395193Albumin 2PROSITE-ProRule annotationAdd
BLAST
Domaini396 – 593198Albumin 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiQ28522.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLFLFSSAYS RGVFRRDTHK SEVAHRFKDL GEEHFKGLVL VAFSQYLQQC
60 70 80 90 100
PFEEHVKLVN EVTEFAKTCV ADESAENCDK SLHTLFGDKL CTVATLRETY
110 120 130 140 150
GEMADCCAKQ EPERNECFLQ HKDDNPNLPP LVRPEVDVMC TAFHDNEATF
160 170 180 190 200
LKKYLYEVAR RHPYFYAPEL LFFAARYKAA FAECCQAADK AACLLPKLDE
210 220 230 240 250
LRDEGKASSA KQRLKCASLQ KFGDRAFKAW AVARLSQKFP KAEFAEVSKL
260 270 280 290 300
VTDLTKVHTE CCHGDLLECA DDRADLAKYM CENQDSISSK LKECCDKPLL
310 320 330 340 350
EKSHCLAEVE NDEMPADLPS LAADYVESKD VCKNYAEAKD VFLGMFLYEY
360 370 380 390 400
ARRHPDYSVM LLLRLAKAYE ATLEKCCAAA DPHECYAKVF DEFQPLVEEP
410 420 430 440 450
QNLVKQNCEL FEQLGEYKFQ NALLVRYTKK VPQVSTPTLV EVSRNLGKVG
460 470 480 490 500
AKCCKLPEAK RMPCAEDYLS VVLNRLCVLH EKTPVSEKVT KCCTESLVNR
510 520 530 540 550
RPCFSALELD EAYVPKAFNA ETFTFHADMC TLSEKEKQVK KQTALVELVK
560 570 580 590 600
HKPKATKEQL KGVMDNFAAF VEKCCKADDK EACFAEEGPK FVAASQAALA
Length:600
Mass (Da):67,881
Last modified:November 1, 1996 - v1
Checksum:iE45C871A670E740B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90463 mRNA. Translation: AAA36906.1.
PIRiA47391.
RefSeqiNP_001182578.1. NM_001195649.1.
UniGeneiMmu.2987.

Genome annotation databases

GeneIDi704892.
KEGGimcc:704892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90463 mRNA. Translation: AAA36906.1.
PIRiA47391.
RefSeqiNP_001182578.1. NM_001195649.1.
UniGeneiMmu.2987.

3D structure databases

ProteinModelPortaliQ28522.
SMRiQ28522. Positions 21-577.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi704892.
KEGGimcc:704892.

Organism-specific databases

CTDi213.

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiQ28522.
KOiK16141.

Miscellaneous databases

NextBioi19959742.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA and protein sequence of polymorphic macaque albumins that differ in bilirubin binding."
    Watkins S.A., Sakamoto Y., Madison J.M., Davis E.M., Smith D.G., Dwulet J., Putnam F.W.
    Proc. Natl. Acad. Sci. U.S.A. 90:2409-2413(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiALBU_MACMU
AccessioniPrimary (citable) accession number: Q28522
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.