Q28506 (PROC_MACMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vitamin K-dependent protein C
EC=3.4.21.69

Alternative name(s):
Anticoagulant protein C
Autoprothrombin IIA
Blood coagulation factor XIV

Gene names

Name:

PROC

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	161 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
Catalytic activity	Degradation of blood coagulation factors Va and VIIIa.
Tissue specificity	Plasma; synthesized in the liver.
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Biological process	Blood coagulation
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›161	›161	Vitamin K-dependent protein C		PRO_0000088711
Regions
	Domain	‹1 – ›161	›161	Peptidase S1
Sites
	Active site	26	1	Charge relay system
	Active site	129	1	Charge relay system
Amino acid modifications
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Glycosylation	82	1	N-linked (GlcNAc...) Potential
	Disulfide bond	100 ↔ 114		By similarity
	Disulfide bond	125 ↔ 153		By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	161	1

Sequences

	Sequence		Length	Mass (Da)
	Q28506 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 27D78F185B2FCC69	FASTA	161	17,770
	10 20 30 40 50 60 EKWELDLDIE EVFIHPNYTK STTDNDIALL RLAQPATLSQ TIVPICLPDS GLAERELTQA 70 80 90 100 110 120 GQETLVTGWG YHSSREKEAK RNRTFILNFI KIPVVPRNEC SEVMSNMVSE NMLCAGILGD 130 140 150 160 RQDACEGDSG GPMVASFHGT WFLVGLVSWG EGCGLLHNYG V

References

[1]	"A comparative study of partial primary structures of the catalytic region of mammalian protein C." Murakawa M., Okamura T., Kamura T., Kuroiwa M., Harada M., Niho Y. Br. J. Haematol. 86:590-600(1994) [PubMed: 8043441] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D43754 Genomic DNA. Translation: BAA07811.1.
3D structure databases
ProteinModelPortal	Q28506.
SMR	Q28506. Positions 1-161.
ModBase	Search...
Protein-protein interaction databases
STRING	Q28506.
Protein family/group databases
MEROPS	S01.218.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	prNOG07393.
GeneTree	ENSGT00560000076714.
HOVERGEN	HBG013304.
InParanoid	Q28506.
OrthoDB	EOG43BMNX.
Family and domain databases
InterPro	IPR009003. Pept_cys/ser_Trypsin-like. IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROC_MACMU

Accession

Primary (citable) accession number: Q28506

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program