Q28505 (FMO2_MACMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 2
EC=1.14.13.8

Alternative name(s):
Dimethylaniline oxidase 2
FMO 1B1
Pulmonary flavin-containing monooxygenase 2
Short name=FMO 2

Gene names

Name:

FMO2

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	535 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
Catalytic activity	N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
Cofactor	FAD By similarity. Magnesium By similarity.
Subcellular location	Microsome membrane. Endoplasmic reticulum membrane By similarity.
Sequence similarities	Belongs to the FMO family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane
Ligand	FAD Flavoprotein Magnesium NADP
Molecular function	Monooxygenase Oxidoreductase
PTM	Acetylation Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	NADPH oxidation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intrinsic to endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro flavin-containing monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 535	534	Dimethylaniline monooxygenase [N-oxide-forming] 2		PRO_0000147647
Regions
	Nucleotide binding	9 – 14	6	FAD Potential
	Nucleotide binding	191 – 196	6	NADP Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Cross-link	492		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q28505 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 85621203B07CCFAE	FASTA	535	60,961
	10 20 30 40 50 60 MAKKVAVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGV WRFKEKVEDG RASIYQSVVT 70 80 90 100 110 120 NTSKEMSCFS DFPMPEDFPN FLHNSKLLEY FRIFAKKFDL LKYIQFQTTV LSVRKCPDFS 130 140 150 160 170 180 SSGQWKVVTQ SNGKEQSAVF DAVMVCTGHH FLPHIPLKSF PGIERFKGQY FHSRQYKHPD 190 200 210 220 230 240 GFEGKRILVI GMGNSGSDIA VELSKSAAQV FISTRHGTWV MSRVSEDGYP WDSVFHTRFR 250 260 270 280 290 300 SMLRNVLPRT VVKWMIEQQM NQWFNHENYG LEPQNKYIMK EPVLNDDVPS RLLCGAIKVK 310 320 330 340 350 360 STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED SLVKVENNMV SLYKYIFPAH 370 380 390 400 410 420 LEKSTFACIG LIQPLGSIFP TAELQARWVT RVFKGLCHLP SERTMMMDII KRNEKRIDLF 430 440 450 460 470 480 GESQSQTLQT NYVDYLDELA LEIGAKPDFC SLLFKDPKLA VRLFFGPCNS YQYRLAGPGQ 490 500 510 520 530 WEGARSAIFT QKQRILKPLK TRVLKDSSNF PVSFLLKILG LVAVVVAFFC QLQWS

References

[1]	"Pulmonary flavin-containing monooxygenase (FMO) in rhesus macaque: expression of FMO2 protein, mRNA and analysis of the cDNA." Yueh M.-F., Krueger S.K., Williams D.E. Biochim. Biophys. Acta 1350:267-271(1997) [PubMed: 9061021] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59453 mRNA. Translation: AAB02939.1.
RefSeq	NP_001036242.1. NM_001042777.1.
UniGene	Mmu.3381.
3D structure databases
ProteinModelPortal	Q28505.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	703639.
KEGG	mcc:703639.
Organism-specific databases
CTD	2329.
Phylogenomic databases
eggNOG	prNOG12177.
GeneTree	ENSGT00550000074292.
HOVERGEN	HBG002037.
InParanoid	Q28505.
OrthoDB	EOG48SGT0.
Family and domain databases
InterPro	IPR012143. DiMe-aniline_mOase. IPR000960. Flavin_mOase. IPR020946. Flavin_mOase-like. IPR002254. Flavin_mOase_2. [Graphical view]
KO	K00485.
Pfam	PF00743. FMO-like. 1 hit. [Graphical view]
PIRSF	PIRSF000332. FMO. 1 hit.
PRINTS	PR00370. FMOXYGENASE. PR01122. FMOXYGENASE2.
ProtoNet	Search...

Entry information

Entry name

FMO2_MACMU

Accession

Primary (citable) accession number: Q28505

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program