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Protein

Apolipoprotein E

Gene

APOE

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000191637‹1 – ›107Apolipoprotein EAdd BLAST›107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74Methionine sulfoxideBy similarity1
Modified residuei78PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Oxidation, Phosphoprotein

Proteomic databases

PRIDEiQ28502.

Expressioni

Tissue specificityi

Secreted in plasma.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000018786.

Structurei

3D structure databases

ProteinModelPortaliQ28502.
SMRiQ28502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 321Add BLAST22
Repeati33 – 542Add BLAST22
Repeati55 – 763Add BLAST22
Repeati77 – 984Add BLAST22
Repeati99 – ›1075›9

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – ›1075 X 22 AA approximate tandem repeatsAdd BLAST›97
Regioni89 – 99LDL receptor bindingBy similarityAdd BLAST11
Regioni93 – 96Heparin-bindingBy similarity4

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
HOGENOMiHOG000034006.
HOVERGENiHBG010582.
InParanoidiQ28502.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q28502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LSPQVTQELT TLMDETMKEL KAYKSELEEQ LSPVAEETRA RLSKELQAAQ
60 70 80 90 100
ARLGADMEDV RSRLVQYRSE VQAMLGQSTE ELRARLASHL RKLRKRLLRD

ADDLQKR
Length:107
Mass (Da):12,382
Last modified:November 1, 1996 - v1
Checksum:iE1D38C32F5AACB23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1071

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52030 mRNA. Translation: AAC50441.1.
UniGeneiMmu.3035.

Similar proteinsi

Entry informationi

Entry nameiAPOE_MACMU
AccessioniPrimary (citable) accession number: Q28502
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families