Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apolipoprotein E

Gene

APOE

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000191637‹1 – ›107Apolipoprotein EAdd BLAST›107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74Methionine sulfoxideBy similarity1
Modified residuei78PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Oxidation, Phosphoprotein

Proteomic databases

PRIDEiQ28502.

Expressioni

Tissue specificityi

Secreted in plasma.

Gene expression databases

BgeeiENSMMUG00000014305.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000018786.

Structurei

3D structure databases

ProteinModelPortaliQ28502.
SMRiQ28502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 321Add BLAST22
Repeati33 – 542Add BLAST22
Repeati55 – 763Add BLAST22
Repeati77 – 984Add BLAST22
Repeati99 – ›1075›9

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – ›1075 X 22 AA approximate tandem repeatsAdd BLAST›97
Regioni89 – 99LDL receptor bindingBy similarityAdd BLAST11
Regioni93 – 96Heparin-bindingBy similarity4

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
HOGENOMiHOG000034006.
HOVERGENiHBG010582.
InParanoidiQ28502.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q28502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LSPQVTQELT TLMDETMKEL KAYKSELEEQ LSPVAEETRA RLSKELQAAQ
60 70 80 90 100
ARLGADMEDV RSRLVQYRSE VQAMLGQSTE ELRARLASHL RKLRKRLLRD

ADDLQKR
Length:107
Mass (Da):12,382
Last modified:November 1, 1996 - v1
Checksum:iE1D38C32F5AACB23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1071

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52030 mRNA. Translation: AAC50441.1.
UniGeneiMmu.3035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52030 mRNA. Translation: AAC50441.1.
UniGeneiMmu.3035.

3D structure databases

ProteinModelPortaliQ28502.
SMRiQ28502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000018786.

Proteomic databases

PRIDEiQ28502.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
HOGENOMiHOG000034006.
HOVERGENiHBG010582.
InParanoidiQ28502.

Gene expression databases

BgeeiENSMMUG00000014305.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPOE_MACMU
AccessioniPrimary (citable) accession number: Q28502
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: March 15, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.