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Protein

Disintegrin and metalloproteinase domain-containing protein 7

Gene

ADAM7

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM12.956.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 7
Short name:
ADAM 7
Alternative name(s):
Epididymal apical protein I
Short name:
EAP I
Gene namesi
Name:ADAM7
Synonyms:EAPI
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 669ExtracellularSequence analysisAdd BLAST644
Transmembranei670 – 690HelicalSequence analysisAdd BLAST21
Topological domaini691 – 776CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000002905424 – 176By similarityAdd BLAST153
ChainiPRO_0000029055177 – 776Disintegrin and metalloproteinase domain-containing protein 7Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi310 ↔ 389By similarity
Disulfide bondi350 ↔ 373By similarity
Disulfide bondi352 ↔ 357By similarity
Disulfide bondi460 ↔ 480By similarity
Glycosylationi584N-linked (GlcNAc...)Sequence analysis1
Glycosylationi629N-linked (GlcNAc...)Sequence analysis1
Glycosylationi665N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed specifically in the caput region of the epididymis. Not detectable in the testis.

Structurei

3D structure databases

ProteinModelPortaliQ28475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 394Peptidase M12BPROSITE-ProRule annotationAdd BLAST196
Domaini402 – 488DisintegrinPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi489 – 669Cys-richAdd BLAST181

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006978.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGCIFLMI LLILQVKEKV ILGVEGQQLV YPKKLPLMQK RDIGHTHDDD
60 70 80 90 100
IEETYEEELM YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGEAFTRH
110 120 130 140 150
LQIMDHCFYQ GSIVHEYDSA ASISTCNGLR GFFRVNDQRY LIEPVKYSDE
160 170 180 190 200
GEHLVFKYNP RVPYVANYSC TELNFTRKTV PGDTESEGDP KMKAIHNEKY
210 220 230 240 250
IELFIVADDT VYRRNSHPHN KLRNRIWGMV NFVNMIYKTL NIHVTLVGIE
260 270 280 290 300
IWTHEDKIEL HSNIETTLLR FSSWQERILK TRKDFDHVVL LSGKWIYTHV
310 320 330 340 350
QGISYPAGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC
360 370 380 390 400
TCPSGKCVMD SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPCNFD
410 420 430 440 450
DFQFCGNKKL DEGEECDCGP PQECTNPCCD AHTCVLKPGF TCAEGECCES
460 470 480 490 500
CQIKKAGSIC RPAEDECDFP EMCTGHSPAC PKDQFRVNGF PCKNSEGYCF
510 520 530 540 550
MGKCPTRRDQ CSELFDDEAT ESHDICYKMN TKGNKFGYCK NKENRFLPCE
560 570 580 590 600
EKDVRCGKIY CTGGELSYLL GEDKTYHLKD PQQNATVKCK TIFLYHDSTD
610 620 630 640 650
IGLVASGTKC GDGMVCNNGE CLNMEKVYNS TNCPSQCHEN PMDDHGLQCH
660 670 680 690 700
CEEGQAPVAW EETLNVTNVA ILIVVLVLVI VGIGVLILLI RYQKCIKLKQ
710 720 730 740 750
VQSPPIETLG VENKGYFGDE QQMRTEPILP EIHFLNQRTP ESLESLPTSF
760 770
SSPHYITLKP ASKDSRGIAD PNQSAK
Length:776
Mass (Da):88,362
Last modified:November 1, 1996 - v1
Checksum:i0208E8C9A8A28C10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66139 mRNA. Translation: CAA46929.1.
PIRiS28258.
UniGeneiMfa.6656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66139 mRNA. Translation: CAA46929.1.
PIRiS28258.
UniGeneiMfa.6656.

3D structure databases

ProteinModelPortaliQ28475.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006978.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADAM7_MACFA
AccessioniPrimary (citable) accession number: Q28475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.