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Protein

Disintegrin and metalloproteinase domain-containing protein 7

Gene

ADAM7

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM12.956.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 7
Short name:
ADAM 7
Alternative name(s):
Epididymal apical protein I
Short name:
EAP I
Gene namesi
Name:ADAM7
Synonyms:EAPI
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 669644ExtracellularSequence analysisAdd
BLAST
Transmembranei670 – 69021HelicalSequence analysisAdd
BLAST
Topological domaini691 – 77686CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 176153By similarityPRO_0000029054Add
BLAST
Chaini177 – 776600Disintegrin and metalloproteinase domain-containing protein 7PRO_0000029055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi310 ↔ 389By similarity
Disulfide bondi350 ↔ 373By similarity
Disulfide bondi352 ↔ 357By similarity
Disulfide bondi460 ↔ 480By similarity
Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence analysis
Glycosylationi629 – 6291N-linked (GlcNAc...)Sequence analysis
Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed specifically in the caput region of the epididymis. Not detectable in the testis.

Structurei

3D structure databases

ProteinModelPortaliQ28475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 394196Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini402 – 48887DisintegrinPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi489 – 669181Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006978.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGCIFLMI LLILQVKEKV ILGVEGQQLV YPKKLPLMQK RDIGHTHDDD
60 70 80 90 100
IEETYEEELM YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGEAFTRH
110 120 130 140 150
LQIMDHCFYQ GSIVHEYDSA ASISTCNGLR GFFRVNDQRY LIEPVKYSDE
160 170 180 190 200
GEHLVFKYNP RVPYVANYSC TELNFTRKTV PGDTESEGDP KMKAIHNEKY
210 220 230 240 250
IELFIVADDT VYRRNSHPHN KLRNRIWGMV NFVNMIYKTL NIHVTLVGIE
260 270 280 290 300
IWTHEDKIEL HSNIETTLLR FSSWQERILK TRKDFDHVVL LSGKWIYTHV
310 320 330 340 350
QGISYPAGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC
360 370 380 390 400
TCPSGKCVMD SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPCNFD
410 420 430 440 450
DFQFCGNKKL DEGEECDCGP PQECTNPCCD AHTCVLKPGF TCAEGECCES
460 470 480 490 500
CQIKKAGSIC RPAEDECDFP EMCTGHSPAC PKDQFRVNGF PCKNSEGYCF
510 520 530 540 550
MGKCPTRRDQ CSELFDDEAT ESHDICYKMN TKGNKFGYCK NKENRFLPCE
560 570 580 590 600
EKDVRCGKIY CTGGELSYLL GEDKTYHLKD PQQNATVKCK TIFLYHDSTD
610 620 630 640 650
IGLVASGTKC GDGMVCNNGE CLNMEKVYNS TNCPSQCHEN PMDDHGLQCH
660 670 680 690 700
CEEGQAPVAW EETLNVTNVA ILIVVLVLVI VGIGVLILLI RYQKCIKLKQ
710 720 730 740 750
VQSPPIETLG VENKGYFGDE QQMRTEPILP EIHFLNQRTP ESLESLPTSF
760 770
SSPHYITLKP ASKDSRGIAD PNQSAK
Length:776
Mass (Da):88,362
Last modified:November 1, 1996 - v1
Checksum:i0208E8C9A8A28C10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66139 mRNA. Translation: CAA46929.1.
PIRiS28258.
UniGeneiMfa.6656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66139 mRNA. Translation: CAA46929.1.
PIRiS28258.
UniGeneiMfa.6656.

3D structure databases

ProteinModelPortaliQ28475.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006978.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A mammalian epididymal protein with remarkable sequence similarity to snake venom haemorrhagic peptides."
    Perry A.C.F., Jones R., Barker P.J., Hall L.
    Biochem. J. 286:671-675(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epididymis.

Entry informationi

Entry nameiADAM7_MACFA
AccessioniPrimary (citable) accession number: Q28475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.