Q28452 (QOR_LAMGU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Quinone oxidoreductase
EC=1.6.5.5

Alternative name(s):
NADPH:quinone reductase
Zeta-crystallin

Gene names

Name:

CRYZ

Organism

Lama guanicoe (Guanaco)

Taxonomic identifier

9840 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Tylopoda › Camelidae › Lama

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding By similarity.
Catalytic activity	NADPH + 2 quinone = NADP+ + 2 semiquinone.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP RNA-binding
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	xenobiotic catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	NADPH binding Inferred from sequence or structural similarity. Source: UniProtKB NADPH:quinone reductase activity Inferred from sequence or structural similarity. Source: UniProtKB mRNA 3'-UTR binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Quinone oxidoreductase		PRO_0000160907
Regions
	Nucleotide binding	158 – 161	4	NADP By similarity
	Nucleotide binding	246 – 249	4	NADP By similarity
	Nucleotide binding	269 – 271	3	NADP By similarity
Sites
	Binding site	53	1	NADP By similarity
	Binding site	181	1	NADP; via amide nitrogen By similarity
	Binding site	200	1	NADP By similarity
	Binding site	229	1	NADP By similarity
Amino acid modifications
	Modified residue	23	1	N6-acetyllysine By similarity
	Modified residue	208	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q28452 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E784E414D2BA23D6	FASTA	330	35,187
	10 20 30 40 50 60 MATGQRLMRA IRVSEFGGPE VLKLQSDVAV PIPEEHQVLI KVQACGVNPV DTYIRSGTYS 70 80 90 100 110 120 RKPRLPYTPG LDVAGLIEAV GERVSAFKKG DRVFTTSTVS GGYAEYALAA DHTVYKLPGE 130 140 150 160 170 180 LDFQKGAAIG VPYFTAYRAL LHSACAKAGE SVLVHGASGG VGLAACQIAR ACCFKVLGTA 190 200 210 220 230 240 GTEEGQRVVL QNGAHEVFNH REDINIDKIK KSVGEKGIDV IIEMLANVNL SNDLNLLSQG 250 260 270 280 290 300 GRVIIVGSKG PVEINPRDTM TKESSIKGVT LFSSTKEEFQ QFAAALQAGM EIGWLRPVIG 310 320 330 SQYPLEKVAQ AHEDLTHSSG AAGKVVLLLK

References

[1]	"Evidence for independent recruitment of zeta-crystallin/quinone reductase (CRYZ) as a crystallin in camelids and hystricomorph rodents." Gonzalez P., Rao P.V., Nunez S.B., Zigler J.S. Jr. Mol. Biol. Evol. 12:773-781(1995) [PubMed: 7476124] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lens.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L34159 mRNA. Translation: AAA99986.1.
3D structure databases
ProteinModelPortal	Q28452.
SMR	Q28452. Positions 6-329.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG002466.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. IPR002364. Quin_OxRdtase/zeta-crystal_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS01162. QOR_ZETA_CRYSTAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QOR_LAMGU

Accession

Primary (citable) accession number: Q28452

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	July 27, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program