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Q28433 (TAP1_GORGO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Antigen peptide transporter 1
Short name=APT1
Alternative name(s):
ATP-binding cassette sub-family B member 2
Peptide transporter TAP1
Gene names
Name:TAP1
OrganismGorilla gorilla gorilla (Lowland gorilla) [Reference proteome]
Taxonomic identifier9595 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla ›

Protein attributes

Sequence length748 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin By similarity.

Subunit structure

Heterodimer of TAP1 and TAP2 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: The transmembrane segments seem to form a pore in the membrane By similarity.

Domain

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 748748Antigen peptide transporter 1
PRO_0000093325

Regions

Topological domain1 – 1515Cytoplasmic Potential
Transmembrane16 – 3621Helical; Name=1; Potential
Topological domain37 – 5317Lumenal Potential
Transmembrane54 – 7623Helical; Name=2; Potential
Topological domain77 – 9216Cytoplasmic Potential
Transmembrane93 – 11321Helical; Name=3; Potential
Topological domain114 – 13320Lumenal Potential
Transmembrane134 – 15421Helical; Name=4; Potential
Topological domain155 – 18632Cytoplasmic Potential
Transmembrane187 – 20721Helical; Name=5; Potential
Topological domain208 – 22720Lumenal Potential
Transmembrane228 – 24821Helical; Name=6; Potential
Topological domain249 – 29850Cytoplasmic Potential
Transmembrane299 – 31921Helical; Name=7; Potential
Topological domain320 – 3289Lumenal Potential
Transmembrane329 – 34921Helical; Name=8; Potential
Topological domain350 – 41869Cytoplasmic Potential
Transmembrane419 – 43921Helical; Name=9; Potential
Topological domain440 – 4434Lumenal Potential
Transmembrane444 – 46421Helical; Name=10; Potential
Topological domain465 – 748284Cytoplasmic Potential
Domain187 – 470284ABC transmembrane type-1
Domain503 – 742240ABC transporter
Nucleotide binding538 – 5458ATP Potential
Region375 – 42046Involved in peptide-binding site
Region453 – 48735Involved in peptide-binding site

Natural variations

Natural variant2331I → V in allele Gogo-TAP1b. Ref.1
VAR_019127
Natural variant2731T → M in allele Gogo-TAP1b. Ref.1
VAR_019128
Natural variant6191C → S in allele Gogo-TAP1b. Ref.1
VAR_019129
Natural variant6291P → R in allele Gogo-TAP1c. Ref.1
VAR_019130

Sequences

Sequence LengthMass (Da)Tools
Q28433 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: D834F6DA0AD6217B

FASTA74880,880
        10         20         30         40         50         60 
MASSRCPAPR GCRCLPGASL AWLGTVLLFL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 

        70         80         90        100        110        120 
GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALEPLA AALGLALPGL ALFRELISWG 

       130        140        150        160        170        180 
APGSADSTRL LHWGSHPSAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 

       190        200        210        220        230        240 
GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 

       250        260        270        280        290        300 
LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNITSRVTE DTSTLSDSLS 

       310        320        330        340        350        360 
ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLVTLPLLFL LPKKVGKWYQ LLEVQVRESL 

       370        380        390        400        410        420 
AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM 

       430        440        450        460        470        480 
LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE 

       490        500        510        520        530        540 
YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLHP GEVTALVGPN 

       550        560        570        580        590        600 
GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 

       610        620        630        640        650        660 
YGLTQKPTME EITAAAVKCG AHSFISGLPQ GYDTEVGEAG SQLSGGQRQA VALARALIRK 

       670        680        690        700        710        720 
PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 

       730        740 
REGGTHQQLM EKKGCYWAMV QAPADAPE

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References

[1]"Transporter associated with antigen-processing-1 (TAP1) alleles in Gorilla gorilla: diversification of the locus postspeciation."
Laud P.R., Loflin P.T., Jeevan A., Lawlor D.A.
Hum. Immunol. 50:91-102(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-233; MET-273; SER-619 AND ARG-629.
Strain: Isolate Machi and Isolate Oko.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L76468 mRNA. Translation: AAA91199.1.
L76469 mRNA. Translation: AAA91200.1.
L76470 mRNA. Translation: AAA91198.1.

3D structure databases

ProteinModelPortalQ28433.
SMRQ28433. Positions 492-742.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG008358.

Family and domain databases

InterProIPR003593. AAA+_ATPase.
IPR013305. ABC_B2.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR005293. Ag_transporter2.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSPR01896. TAP1PROTEIN.
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 1 hit.
TIGRFAMsTIGR00958. 3a01208. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTAP1_GORGO
AccessionPrimary (citable) accession number: Q28433
Secondary accession number(s): Q28432, Q28434
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: April 3, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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