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Protein

Antigen peptide transporter 1

Gene

TAP1

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi538 – 545ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity, Peptide transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen peptide transporter 1
Short name:
APT1
Alternative name(s):
ATP-binding cassette sub-family B member 2
Peptide transporter TAP1
Gene namesi
Name:TAP1
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini37 – 53LumenalSequence analysisAdd BLAST17
Transmembranei54 – 76Helical; Name=2PROSITE-ProRule annotationAdd BLAST23
Topological domaini77 – 92CytoplasmicSequence analysisAdd BLAST16
Transmembranei93 – 113Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini114 – 133LumenalSequence analysisAdd BLAST20
Transmembranei134 – 154Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini155 – 186CytoplasmicSequence analysisAdd BLAST32
Transmembranei187 – 207Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini208 – 227LumenalSequence analysisAdd BLAST20
Transmembranei228 – 248Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini249 – 298CytoplasmicSequence analysisAdd BLAST50
Transmembranei299 – 319Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini320 – 328LumenalSequence analysis9
Transmembranei329 – 349Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini350 – 418CytoplasmicSequence analysisAdd BLAST69
Transmembranei419 – 439Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini440 – 443LumenalSequence analysis4
Transmembranei444 – 464Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini465 – 748CytoplasmicSequence analysisAdd BLAST284

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933251 – 748Antigen peptide transporter 1Add BLAST748

Interactioni

Subunit structurei

Heterodimer of TAP1 and TAP2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ28433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 470ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST284
Domaini503 – 742ABC transporterPROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni375 – 420Involved in peptide-binding siteAdd BLAST46
Regioni453 – 487Involved in peptide-binding siteAdd BLAST35

Domaini

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG008358.
InParanoidiQ28433.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR013306. Tap1/ABCB2.
[Graphical view]
PANTHERiPTHR24221:SF249. PTHR24221:SF249. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSRCPAPR GCRCLPGASL AWLGTVLLFL ADWVLLRTAL PRIFSLLVPT
60 70 80 90 100
ALPLLRVWAV GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALEPLA
110 120 130 140 150
AALGLALPGL ALFRELISWG APGSADSTRL LHWGSHPSAF VVSYAAALPA
160 170 180 190 200
AALWHKLGSL WVPGGQGGSG NPVRRLLGCL GSETRRLSLF LVLVVLSSLG
210 220 230 240 250
EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV LEFVGDGIYN
260 270 280 290 300
NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNITSRVTE DTSTLSDSLS
310 320 330 340 350
ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLVTLPLLFL LPKKVGKWYQ
360 370 380 390 400
LLEVQVRESL AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL
410 420 430 440 450
NQKEAVAYAV NSWTTSISGM LLKVGILYIG GQLVTSGAVS SGNLVTFVLY
460 470 480 490 500
QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE YLDRTPRCPP SGLLTPLHLE
510 520 530 540 550
GLVQFQDVSF AYPNRPDVLV LQGLTFTLHP GEVTALVGPN GSGKSTVAAL
560 570 580 590 600
LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA
610 620 630 640 650
YGLTQKPTME EITAAAVKCG AHSFISGLPQ GYDTEVGEAG SQLSGGQRQA
660 670 680 690 700
VALARALIRK PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT
710 720 730 740
QHLSLVEQAD HILFLEGGAI REGGTHQQLM EKKGCYWAMV QAPADAPE
Length:748
Mass (Da):80,880
Last modified:July 19, 2004 - v2
Checksum:iD834F6DA0AD6217B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019127233I → V in allele Gogo-TAP1b. 1 Publication1
Natural variantiVAR_019128273T → M in allele Gogo-TAP1b. 1 Publication1
Natural variantiVAR_019129619C → S in allele Gogo-TAP1b. 1 Publication1
Natural variantiVAR_019130629P → R in allele Gogo-TAP1c. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76468 mRNA. Translation: AAA91199.1.
L76469 mRNA. Translation: AAA91200.1.
L76470 mRNA. Translation: AAA91198.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76468 mRNA. Translation: AAA91199.1.
L76469 mRNA. Translation: AAA91200.1.
L76470 mRNA. Translation: AAA91198.1.

3D structure databases

ProteinModelPortaliQ28433.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008358.
InParanoidiQ28433.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR013306. Tap1/ABCB2.
[Graphical view]
PANTHERiPTHR24221:SF249. PTHR24221:SF249. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAP1_GORGO
AccessioniPrimary (citable) accession number: Q28433
Secondary accession number(s): Q28432, Q28434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 5, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.