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Protein

Antigen peptide transporter 1

Gene

TAP1

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi538 – 5458ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity, Peptide transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen peptide transporter 1
Short name:
APT1
Alternative name(s):
ATP-binding cassette sub-family B member 2
Peptide transporter TAP1
Gene namesi
Name:TAP1
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence analysisAdd
BLAST
Transmembranei16 – 3621Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Topological domaini37 – 5317LumenalSequence analysisAdd
BLAST
Transmembranei54 – 7623Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Topological domaini77 – 9216CytoplasmicSequence analysisAdd
BLAST
Transmembranei93 – 11321Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Topological domaini114 – 13320LumenalSequence analysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Topological domaini155 – 18632CytoplasmicSequence analysisAdd
BLAST
Transmembranei187 – 20721Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Topological domaini208 – 22720LumenalSequence analysisAdd
BLAST
Transmembranei228 – 24821Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Topological domaini249 – 29850CytoplasmicSequence analysisAdd
BLAST
Transmembranei299 – 31921Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Topological domaini320 – 3289LumenalSequence analysis
Transmembranei329 – 34921Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Topological domaini350 – 41869CytoplasmicSequence analysisAdd
BLAST
Transmembranei419 – 43921Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Topological domaini440 – 4434LumenalSequence analysis
Transmembranei444 – 46421Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Topological domaini465 – 748284CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Antigen peptide transporter 1PRO_0000093325Add
BLAST

Interactioni

Subunit structurei

Heterodimer of TAP1 and TAP2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ28433.
SMRiQ28433. Positions 492-742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 470284ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini503 – 742240ABC transporterPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni375 – 42046Involved in peptide-binding siteAdd
BLAST
Regioni453 – 48735Involved in peptide-binding siteAdd
BLAST

Domaini

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG008358.
InParanoidiQ28433.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR013306. Tap1/ABCB2.
[Graphical view]
PANTHERiPTHR24221:SF249. PTHR24221:SF249. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSRCPAPR GCRCLPGASL AWLGTVLLFL ADWVLLRTAL PRIFSLLVPT
60 70 80 90 100
ALPLLRVWAV GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALEPLA
110 120 130 140 150
AALGLALPGL ALFRELISWG APGSADSTRL LHWGSHPSAF VVSYAAALPA
160 170 180 190 200
AALWHKLGSL WVPGGQGGSG NPVRRLLGCL GSETRRLSLF LVLVVLSSLG
210 220 230 240 250
EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV LEFVGDGIYN
260 270 280 290 300
NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNITSRVTE DTSTLSDSLS
310 320 330 340 350
ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLVTLPLLFL LPKKVGKWYQ
360 370 380 390 400
LLEVQVRESL AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL
410 420 430 440 450
NQKEAVAYAV NSWTTSISGM LLKVGILYIG GQLVTSGAVS SGNLVTFVLY
460 470 480 490 500
QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE YLDRTPRCPP SGLLTPLHLE
510 520 530 540 550
GLVQFQDVSF AYPNRPDVLV LQGLTFTLHP GEVTALVGPN GSGKSTVAAL
560 570 580 590 600
LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA
610 620 630 640 650
YGLTQKPTME EITAAAVKCG AHSFISGLPQ GYDTEVGEAG SQLSGGQRQA
660 670 680 690 700
VALARALIRK PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT
710 720 730 740
QHLSLVEQAD HILFLEGGAI REGGTHQQLM EKKGCYWAMV QAPADAPE
Length:748
Mass (Da):80,880
Last modified:July 19, 2004 - v2
Checksum:iD834F6DA0AD6217B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti233 – 2331I → V in allele Gogo-TAP1b. 1 Publication
VAR_019127
Natural varianti273 – 2731T → M in allele Gogo-TAP1b. 1 Publication
VAR_019128
Natural varianti619 – 6191C → S in allele Gogo-TAP1b. 1 Publication
VAR_019129
Natural varianti629 – 6291P → R in allele Gogo-TAP1c. 1 Publication
VAR_019130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76468 mRNA. Translation: AAA91199.1.
L76469 mRNA. Translation: AAA91200.1.
L76470 mRNA. Translation: AAA91198.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76468 mRNA. Translation: AAA91199.1.
L76469 mRNA. Translation: AAA91200.1.
L76470 mRNA. Translation: AAA91198.1.

3D structure databases

ProteinModelPortaliQ28433.
SMRiQ28433. Positions 492-742.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008358.
InParanoidiQ28433.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR013306. Tap1/ABCB2.
[Graphical view]
PANTHERiPTHR24221:SF249. PTHR24221:SF249. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Transporter associated with antigen-processing-1 (TAP1) alleles in Gorilla gorilla: diversification of the locus postspeciation."
    Laud P.R., Loflin P.T., Jeevan A., Lawlor D.A.
    Hum. Immunol. 50:91-102(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-233; MET-273; SER-619 AND ARG-629.
    Strain: Isolate Machi and Isolate Oko.

Entry informationi

Entry nameiTAP1_GORGO
AccessioniPrimary (citable) accession number: Q28433
Secondary accession number(s): Q28432, Q28434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: January 20, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.