Q28409 (PENK_FELCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proenkephalin-A

Cleaved into the following 3 chains:

1. Synenkephalin
2. Met-enkephalin
3. Leu-enkephalin

Gene names

Name:

PENK

Organism

Felis catus (Cat) (Felis silvestris catus) [Complete proteome]

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	187 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Subcellular location	Secreted.
Post-translational modification	The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Sequence similarities	Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Endorphin Neuropeptide Opioid peptide
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	‹1 – 34	›34	Synenkephalin		PRO_0000008232
	Peptide	38 – 42	5	Met-enkephalin		PRO_0000008233
	Peptide	45 – 49	5	Met-enkephalin		PRO_0000008234
	Propeptide	52 – 70	19			PRO_0000008235
	Peptide	73 – 77	5	Met-enkephalin		PRO_0000008236
	Propeptide	80 – 143	64			PRO_0000008237
	Peptide	146 – 150	5	Met-enkephalin		PRO_0000008238
	Propeptide	153 – 163	11			PRO_0000008239
	Peptide	166 – 170	5	Leu-enkephalin		PRO_0000008240
	Propeptide	173 – ›187	›15			PRO_0000008241
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	187	1

Sequences

	Sequence		Length	Mass (Da)
	Q28409 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 0D1837460773E433	FASTA	187	21,267
	10 20 30 40 50 60 WETCKEFLKL SQLEIPQDGT SALRESSPEE SHALRKKYGG FMKRYGGFMK KMDELYPQEP 70 80 90 100 110 120 EEEAPAEILA KRYGGFMKKD AEEEEDALAS SSDLLKELLG PGETETAAAP RGRDDEDVSK 130 140 150 160 170 180 SHGGFMRALK GSPQLAQEAK MLQKRYGGFM RRVGRPEWWM DYQKRYGGFL KRFADSLPSD EEGESYS

References

[1]	"Cat proenkephalin-A does not contain the opioid octapeptide." Chaminade M., Chelot E., de Carvalho L., Bochet P., Rossier J. Neurochem. Int. 28:155-160(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adrenal medulla.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U24247 mRNA. Translation: AAC48512.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9685.ENSFCAP00000011717.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG40630.
HOVERGEN	HBG000063.
Family and domain databases
InterPro	IPR006024. Opioid_neupept. IPR000703. Proenkphlin_A. [Graphical view]
PANTHER	PTHR11438. PTHR11438. 1 hit. PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PRINTS	PR01029. PENKAPRCRSR.
PROSITE	PS01252. OPIOIDS_PRECURSOR. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PENK_FELCA

Accession

Primary (citable) accession number: Q28409

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program