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Protein

Proenkephalin-A

Gene

PENK

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A
Cleaved into the following 3 chains:
Gene namesi
Name:PENK
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_0000008232‹1 – 34SynenkephalinAdd BLAST›34
PeptideiPRO_000000823338 – 42Met-enkephalin5
PeptideiPRO_000000823445 – 49Met-enkephalin5
PropeptideiPRO_000000823552 – 70Add BLAST19
PeptideiPRO_000000823673 – 77Met-enkephalin5
PropeptideiPRO_000000823780 – 143Add BLAST64
PeptideiPRO_0000008238146 – 150Met-enkephalin5
PropeptideiPRO_0000008239153 – 163Add BLAST11
PeptideiPRO_0000008240166 – 170Leu-enkephalin5
PropeptideiPRO_0000008241173 – ›187Add BLAST›15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187PhosphoserineBy similarity1

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000063.
InParanoidiQ28409.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PRINTSiPR01029. PENKAPRCRSR.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
WETCKEFLKL SQLEIPQDGT SALRESSPEE SHALRKKYGG FMKRYGGFMK
60 70 80 90 100
KMDELYPQEP EEEAPAEILA KRYGGFMKKD AEEEEDALAS SSDLLKELLG
110 120 130 140 150
PGETETAAAP RGRDDEDVSK SHGGFMRALK GSPQLAQEAK MLQKRYGGFM
160 170 180
RRVGRPEWWM DYQKRYGGFL KRFADSLPSD EEGESYS
Length:187
Mass (Da):21,267
Last modified:November 1, 1997 - v1
Checksum:i0D1837460773E433
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1871

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24247 mRNA. Translation: AAC48512.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24247 mRNA. Translation: AAC48512.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000063.
InParanoidiQ28409.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PRINTSiPR01029. PENKAPRCRSR.
ProtoNetiSearch...

Entry informationi

Entry nameiPENK_FELCA
AccessioniPrimary (citable) accession number: Q28409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.