SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q28409

- PENK_FELCA

UniProt

Q28409 - PENK_FELCA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Proenkephalin-A

Gene
PENK
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A
Cleaved into the following 3 chains:
Gene namesi
Name:PENK
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei‹1 – 34›34SynenkephalinPRO_0000008232Add
BLAST
Peptidei38 – 425Met-enkephalinPRO_0000008233
Peptidei45 – 495Met-enkephalinPRO_0000008234
Propeptidei52 – 7019PRO_0000008235Add
BLAST
Peptidei73 – 775Met-enkephalinPRO_0000008236
Propeptidei80 – 14364PRO_0000008237Add
BLAST
Peptidei146 – 1505Met-enkephalinPRO_0000008238
Propeptidei153 – 16311PRO_0000008239Add
BLAST
Peptidei166 – 1705Leu-enkephalinPRO_0000008240
Propeptidei173 – ›187›15PRO_0000008241Add
BLAST

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011717.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG40630.
HOVERGENiHBG000063.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PRINTSiPR01029. PENKAPRCRSR.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28409-1 [UniParc]FASTAAdd to Basket

« Hide

WETCKEFLKL SQLEIPQDGT SALRESSPEE SHALRKKYGG FMKRYGGFMK    50
KMDELYPQEP EEEAPAEILA KRYGGFMKKD AEEEEDALAS SSDLLKELLG 100
PGETETAAAP RGRDDEDVSK SHGGFMRALK GSPQLAQEAK MLQKRYGGFM 150
RRVGRPEWWM DYQKRYGGFL KRFADSLPSD EEGESYS 187
Length:187
Mass (Da):21,267
Last modified:November 1, 1997 - v1
Checksum:i0D1837460773E433
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei187 – 1871

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24247 mRNA. Translation: AAC48512.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24247 mRNA. Translation: AAC48512.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000011717.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG40630.
HOVERGENi HBG000063.

Family and domain databases

InterProi IPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PRINTSi PR01029. PENKAPRCRSR.
ProtoNeti Search...

Publicationsi

  1. "Cat proenkephalin-A does not contain the opioid octapeptide."
    Chaminade M., Chelot E., de Carvalho L., Bochet P., Rossier J.
    Neurochem. Int. 28:155-160(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal medulla.

Entry informationi

Entry nameiPENK_FELCA
AccessioniPrimary (citable) accession number: Q28409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi