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Protein

Proenkephalin-A

Gene

PENK

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A
Cleaved into the following 3 chains:
Gene namesi
Name:PENK
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei‹1 – 34›34SynenkephalinPRO_0000008232Add
BLAST
Peptidei38 – 425Met-enkephalinPRO_0000008233
Peptidei45 – 495Met-enkephalinPRO_0000008234
Propeptidei52 – 7019PRO_0000008235Add
BLAST
Peptidei73 – 775Met-enkephalinPRO_0000008236
Propeptidei80 – 14364PRO_0000008237Add
BLAST
Peptidei146 – 1505Met-enkephalinPRO_0000008238
Propeptidei153 – 16311PRO_0000008239Add
BLAST
Peptidei166 – 1705Leu-enkephalinPRO_0000008240
Propeptidei173 – ›187›15PRO_0000008241Add
BLAST

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011717.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG40630.
HOVERGENiHBG000063.
InParanoidiQ28409.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PRINTSiPR01029. PENKAPRCRSR.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28409-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
WETCKEFLKL SQLEIPQDGT SALRESSPEE SHALRKKYGG FMKRYGGFMK
60 70 80 90 100
KMDELYPQEP EEEAPAEILA KRYGGFMKKD AEEEEDALAS SSDLLKELLG
110 120 130 140 150
PGETETAAAP RGRDDEDVSK SHGGFMRALK GSPQLAQEAK MLQKRYGGFM
160 170 180
RRVGRPEWWM DYQKRYGGFL KRFADSLPSD EEGESYS
Length:187
Mass (Da):21,267
Last modified:November 1, 1997 - v1
Checksum:i0D1837460773E433
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei187 – 1871

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24247 mRNA. Translation: AAC48512.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24247 mRNA. Translation: AAC48512.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG40630.
HOVERGENiHBG000063.
InParanoidiQ28409.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PRINTSiPR01029. PENKAPRCRSR.
ProtoNetiSearch...

Publicationsi

  1. "Cat proenkephalin-A does not contain the opioid octapeptide."
    Chaminade M., Chelot E., de Carvalho L., Bochet P., Rossier J.
    Neurochem. Int. 28:155-160(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal medulla.

Entry informationi

Entry nameiPENK_FELCA
AccessioniPrimary (citable) accession number: Q28409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.