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Q28409 (PENK_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proenkephalin-A

Cleaved into the following 3 chains:

  1. Synenkephalin
  2. Met-enkephalin
  3. Leu-enkephalin
Gene names
Name:PENK
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length187 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.

Subcellular location

Secreted.

Post-translational modification

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionEndorphin
Neuropeptide
Opioid peptide
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide‹1 – 34›34Synenkephalin
PRO_0000008232
Peptide38 – 425Met-enkephalin
PRO_0000008233
Peptide45 – 495Met-enkephalin
PRO_0000008234
Propeptide52 – 7019
PRO_0000008235
Peptide73 – 775Met-enkephalin
PRO_0000008236
Propeptide80 – 14364
PRO_0000008237
Peptide146 – 1505Met-enkephalin
PRO_0000008238
Propeptide153 – 16311
PRO_0000008239
Peptide166 – 1705Leu-enkephalin
PRO_0000008240
Propeptide173 – ›187›15
PRO_0000008241

Experimental info

Non-terminal residue11
Non-terminal residue1871

Sequences

Sequence LengthMass (Da)Tools
Q28409 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 0D1837460773E433

FASTA18721,267
        10         20         30         40         50         60 
WETCKEFLKL SQLEIPQDGT SALRESSPEE SHALRKKYGG FMKRYGGFMK KMDELYPQEP 

        70         80         90        100        110        120 
EEEAPAEILA KRYGGFMKKD AEEEEDALAS SSDLLKELLG PGETETAAAP RGRDDEDVSK 

       130        140        150        160        170        180 
SHGGFMRALK GSPQLAQEAK MLQKRYGGFM RRVGRPEWWM DYQKRYGGFL KRFADSLPSD 


EEGESYS 

« Hide

References

[1]"Cat proenkephalin-A does not contain the opioid octapeptide."
Chaminade M., Chelot E., de Carvalho L., Bochet P., Rossier J.
Neurochem. Int. 28:155-160(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adrenal medulla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U24247 mRNA. Translation: AAC48512.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000011717.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG40630.
HOVERGENHBG000063.

Family and domain databases

InterProIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PRINTSPR01029. PENKAPRCRSR.
ProtoNetSearch...

Entry information

Entry namePENK_FELCA
AccessionPrimary (citable) accession number: Q28409
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families