Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q28409

- PENK_FELCA

UniProt

Q28409 - PENK_FELCA

Protein

Proenkephalin-A

Gene

PENK

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endorphin, Neuropeptide, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proenkephalin-A
    Cleaved into the following 3 chains:
    Gene namesi
    Name:PENK
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei‹1 – 34›34SynenkephalinPRO_0000008232Add
    BLAST
    Peptidei38 – 425Met-enkephalinPRO_0000008233
    Peptidei45 – 495Met-enkephalinPRO_0000008234
    Propeptidei52 – 7019PRO_0000008235Add
    BLAST
    Peptidei73 – 775Met-enkephalinPRO_0000008236
    Propeptidei80 – 14364PRO_0000008237Add
    BLAST
    Peptidei146 – 1505Met-enkephalinPRO_0000008238
    Propeptidei153 – 16311PRO_0000008239Add
    BLAST
    Peptidei166 – 1705Leu-enkephalinPRO_0000008240
    Propeptidei173 – ›187›15PRO_0000008241Add
    BLAST

    Post-translational modificationi

    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000011717.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG40630.
    HOVERGENiHBG000063.

    Family and domain databases

    InterProiIPR006024. Opioid_neupept.
    IPR000703. Proenkphlin_A.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF3. PTHR11438:SF3. 1 hit.
    PRINTSiPR01029. PENKAPRCRSR.

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28409-1 [UniParc]FASTAAdd to Basket

    « Hide

    WETCKEFLKL SQLEIPQDGT SALRESSPEE SHALRKKYGG FMKRYGGFMK    50
    KMDELYPQEP EEEAPAEILA KRYGGFMKKD AEEEEDALAS SSDLLKELLG 100
    PGETETAAAP RGRDDEDVSK SHGGFMRALK GSPQLAQEAK MLQKRYGGFM 150
    RRVGRPEWWM DYQKRYGGFL KRFADSLPSD EEGESYS 187
    Length:187
    Mass (Da):21,267
    Last modified:November 1, 1997 - v1
    Checksum:i0D1837460773E433
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei187 – 1871

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24247 mRNA. Translation: AAC48512.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24247 mRNA. Translation: AAC48512.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000011717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG40630.
    HOVERGENi HBG000063.

    Family and domain databases

    InterProi IPR006024. Opioid_neupept.
    IPR000703. Proenkphlin_A.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF3. PTHR11438:SF3. 1 hit.
    PRINTSi PR01029. PENKAPRCRSR.
    ProtoNeti Search...

    Publicationsi

    1. "Cat proenkephalin-A does not contain the opioid octapeptide."
      Chaminade M., Chelot E., de Carvalho L., Bochet P., Rossier J.
      Neurochem. Int. 28:155-160(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adrenal medulla.

    Entry informationi

    Entry nameiPENK_FELCA
    AccessioniPrimary (citable) accession number: Q28409
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3