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Protein

Aldehyde dehydrogenase, cytosolic 1

Gene

ALDH1

Organism
Elephantulus edwardii (Cape long-eared elephant shrew)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major component of the eye of elephant shrews, which in contrast to other mammals, possesses both a lens- and a non-lens class-1 aldehyde dehydrogenase 1. This eye-specific form is a structural protein of the lens and, in other part of the eye, serves as the major form of ALDH1. Can convert/oxidize retinaldehyde to retinoic acid.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, cytosolic 1 (ALDH1)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei170Transition state stabilizer1
Active sitei269Proton acceptor1
Active sitei303Nucleophile1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 251NAD1 Publication6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.36. 7360.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, cytosolic 1 (EC:1.2.1.3)
Alternative name(s):
ALDH class 1
ETA-crystallin
Gene namesi
Name:ALDH1
OrganismiElephantulus edwardii (Cape long-eared elephant shrew)
Taxonomic identifieri28737 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaMacroscelideaMacroscelididaeElephantulus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564271 – 501Aldehyde dehydrogenase, cytosolic 1Add BLAST501

Proteomic databases

PRIDEiQ28399.

Expressioni

Tissue specificityi

Eye specific, with very high expression in the lens.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

Secondary structure

1501
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 25Combined sources4
Beta strandi28 – 30Combined sources3
Beta strandi37 – 41Combined sources5
Turni43 – 45Combined sources3
Beta strandi48 – 53Combined sources6
Helixi57 – 71Combined sources15
Helixi76 – 79Combined sources4
Helixi82 – 98Combined sources17
Helixi100 – 111Combined sources12
Helixi115 – 120Combined sources6
Helixi122 – 136Combined sources15
Helixi137 – 139Combined sources3
Beta strandi142 – 145Combined sources4
Beta strandi148 – 159Combined sources12
Beta strandi162 – 166Combined sources5
Helixi172 – 185Combined sources14
Beta strandi189 – 193Combined sources5
Helixi200 – 212Combined sources13
Beta strandi218 – 221Combined sources4
Turni226 – 228Combined sources3
Helixi229 – 234Combined sources6
Beta strandi241 – 246Combined sources6
Helixi248 – 260Combined sources13
Beta strandi265 – 269Combined sources5
Beta strandi274 – 278Combined sources5
Helixi284 – 296Combined sources13
Helixi297 – 300Combined sources4
Beta strandi306 – 312Combined sources7
Helixi313 – 326Combined sources14
Helixi348 – 364Combined sources17
Beta strandi367 – 370Combined sources4
Beta strandi373 – 379Combined sources7
Beta strandi385 – 390Combined sources6
Helixi395 – 398Combined sources4
Beta strandi403 – 411Combined sources9
Helixi414 – 422Combined sources9
Beta strandi423 – 425Combined sources3
Beta strandi428 – 433Combined sources6
Helixi437 – 446Combined sources10
Beta strandi449 – 455Combined sources7
Helixi470 – 472Combined sources3
Beta strandi473 – 475Combined sources3
Helixi479 – 483Combined sources5
Helixi484 – 486Combined sources3
Beta strandi487 – 495Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O9JX-ray2.40A/B/C/D1-501[»]
1PEJmodel-A1-501[»]
ProteinModelPortaliQ28399.
SMRiQ28399.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ28399.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOVERGENiHBG000097.
OrthoDBiEOG091G05E8.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSGMPDLP APLTNIKIQH TKLFINNEWH ESVSGKTFPV FNPATEEKIC
60 70 80 90 100
EVEEADKEDV DKAVKAAREA FQMGSPWRTM DASERGQLIY KLADLIERDR
110 120 130 140 150
LLLATLESIN AGKVFASAYL MDLDYCIKAL RYCAGWADKI QGRTIPVDGE
160 170 180 190 200
FFSYTRHEPI GVCGLIFPWN APMILLACKI GPALCCGNTV IVKPAEQTPL
210 220 230 240 250
TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD KVAFTGSTEV
260 270 280 290 300
GKMIQEAAAK SNLKRVTLEL GAKNPCIVFA DADLDSAVEF AHQGVFTNQG
310 320 330 340 350
QSCIAASKLF VEEAIYDEFV QRSVERAKKY VFGNPLTPGV NHGPQINKAQ
360 370 380 390 400
HNKIMELIES GKKEGAKLEC GGGPWGNKGY FIQPTVFSNV TDDMRIAKEE
410 420 430 440 450
IFGPVQQIMK FKSLDEVIKR ANNTYYGLVA GVFTKDLDKA VTVSSALQAG
460 470 480 490 500
TVWVNCYLAA SAQSPAGGFK MSGHGREMGE YGIHEYTEVK TVTMKISEKN

S
Length:501
Mass (Da):54,538
Last modified:November 1, 1996 - v1
Checksum:i9E3D5BBE083ACAD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02483 mRNA. Translation: AAB60268.1.
RefSeqiNP_001277088.1. NM_001290159.1.

Genome annotation databases

GeneIDi102867337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02483 mRNA. Translation: AAB60268.1.
RefSeqiNP_001277088.1. NM_001290159.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O9JX-ray2.40A/B/C/D1-501[»]
1PEJmodel-A1-501[»]
ProteinModelPortaliQ28399.
SMRiQ28399.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ28399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102867337.

Organism-specific databases

CTDi102867337.

Phylogenomic databases

HOVERGENiHBG000097.
OrthoDBiEOG091G05E8.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
BRENDAi1.2.1.36. 7360.

Miscellaneous databases

EvolutionaryTraceiQ28399.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALDH1_ELEED
AccessioniPrimary (citable) accession number: Q28399
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.