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Protein

Uterocalin

Gene
N/A
Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds fatty acids and retinol. Is specialized for the preattachment embryo. May be important to maintain the pregnancy and may transport small hydrophobic ligands from mother to the developing embryo.2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Uterocalin
Alternative name(s):
Concepticalin
Equicalin
Lipocalin P19
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi150 – 1501W → E: No effect. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 180162UterocalinPRO_0000249685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi82 ↔ 175By similarity
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28388.

Expressioni

Tissue specificityi

Expressed in glandular and lumenal epithelia of the endometrium. Is transferred to the embryonic capsule, the conceptus and the yolk sac.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ28388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KEYS. Eukaryota.
ENOG41116UH. LUCA.
HOGENOMiHOG000171062.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLLLAMGL ILPRRPHALH MGPGDPNFDE KLVKGKWFSV ALASNEPKFI
60 70 80 90 100
AKDTDMKFFI HKIQVTPESL QFHFHRKVRG MCVPTMMTAH KTKKKFQYTV
110 120 130 140 150
NHSGHKTIFL EKVDPKHFVI FCAHSMKHGK ETVVVTLFSR TPTVSPDVMW
160 170 180
MFKKYCKTHG IHTSNIVDLT QTDRCLHARH
Length:180
Mass (Da):20,805
Last modified:November 1, 1996 - v1
Checksum:i892BB394BEF93417
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98459 mRNA. Translation: CAA67099.1.
RefSeqiNP_001075978.2. NM_001082509.2.
UniGeneiEca.12486.

Genome annotation databases

GeneIDi100034213.
KEGGiecb:100034213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98459 mRNA. Translation: CAA67099.1.
RefSeqiNP_001075978.2. NM_001082509.2.
UniGeneiEca.12486.

3D structure databases

ProteinModelPortaliQ28388.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ28388.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034213.
KEGGiecb:100034213.

Organism-specific databases

CTDi100034213.

Phylogenomic databases

eggNOGiENOG410KEYS. Eukaryota.
ENOG41116UH. LUCA.
HOGENOMiHOG000171062.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A 19 kDa protein secreted bythe endometrium of the mare is a novel member of the lipocalin family."
    Crossett B., Allen W.R., Stewart F.
    Biochem. J. 320:137-143(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-42, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Endometrium.
  2. "Transfer of a uterine lipocalin from the endometrium of the mare to the developing equine conceptus."
    Crossett B., Suire S., Herrler A., Allen W.R., Stewart F.
    Biol. Reprod. 59:483-490(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  3. "Uterocalin, a lipocalin provisioning the preattachment equine conceptus: fatty acid and retinol binding properties, and structural characterization."
    Suire S., Stewart F., Beauchamp J., Kennedy M.W.
    Biochem. J. 356:369-376(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF TRP-150.

Entry informationi

Entry nameiUCAL_HORSE
AccessioniPrimary (citable) accession number: Q28388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.