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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:IL1A
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152631 – 112By similarityAdd BLAST112
ChainiPRO_0000015264113 – 270Interleukin-1 alphaAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineBy similarity1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ28385

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000021137

Structurei

3D structure databases

ProteinModelPortaliQ28385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI Eukaryota
ENOG411151X LUCA
HOGENOMiHOG000113034
HOVERGENiHBG002432
InParanoidiQ28385
KOiK04383

Family and domain databases

InterProiView protein in InterPro
IPR003295 IL-1_alpha
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR45409 PTHR45409, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01358 INTRLEUKIN1A
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENED YSSEIDHLSL TQKSFYDASY DPLPEDCMDT
60 70 80 90 100
FMSLSTSETS KTSKLNFKES VVLVAANGKT LKKRRLSLNQ FITNDDLEAI
110 120 130 140 150
ANDPEEGIIR PRSVHYNFQS NTKYNFMRIV NHQCTLNDAL NQSVIRDTSG
160 170 180 190 200
QYLATAALNN LDDAVKFDMG AYTSEEDSQL PVTLRISKTR LFVSAQNEDE
210 220 230 240 250
PVLLKEMPDT PKTIKDETNL LFFWERHGSK NYFKSVAHPK LFIATKQGKL
260 270
VHMARGQPSI TDFQILDNQF
Length:270
Mass (Da):30,807
Last modified:November 1, 1996 - v1
Checksum:i381859713754DB90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110R → K in AAC39255 (PubMed:9622738).Curated1
Sequence conflicti150G → V in AAC39255 (PubMed:9622738).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42146 mRNA Translation: BAA07717.1
U92480 mRNA Translation: AAC39255.1
RefSeqiNP_001075969.2, NM_001082500.2
UniGeneiEca.13125

Genome annotation databases

GeneIDi100064969
KEGGiecb:100064969

Similar proteinsi

Entry informationi

Entry nameiIL1A_HORSE
AccessioniPrimary (citable) accession number: Q28385
Secondary accession number(s): O77743
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health