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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Mitogen, Pyrogen

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:IL1A
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

  • Secreted

  • Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152631 – 112By similarityAdd BLAST112
ChainiPRO_0000015264113 – 270Interleukin-1 alphaAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineBy similarity1
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ28385.
PRIDEiQ28385.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000021137.

Structurei

3D structure databases

ProteinModelPortaliQ28385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiQ28385.
KOiK04383.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENED YSSEIDHLSL TQKSFYDASY DPLPEDCMDT
60 70 80 90 100
FMSLSTSETS KTSKLNFKES VVLVAANGKT LKKRRLSLNQ FITNDDLEAI
110 120 130 140 150
ANDPEEGIIR PRSVHYNFQS NTKYNFMRIV NHQCTLNDAL NQSVIRDTSG
160 170 180 190 200
QYLATAALNN LDDAVKFDMG AYTSEEDSQL PVTLRISKTR LFVSAQNEDE
210 220 230 240 250
PVLLKEMPDT PKTIKDETNL LFFWERHGSK NYFKSVAHPK LFIATKQGKL
260 270
VHMARGQPSI TDFQILDNQF
Length:270
Mass (Da):30,807
Last modified:November 1, 1996 - v1
Checksum:i381859713754DB90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110R → K in AAC39255 (PubMed:9622738).Curated1
Sequence conflicti150G → V in AAC39255 (PubMed:9622738).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42146 mRNA. Translation: BAA07717.1.
U92480 mRNA. Translation: AAC39255.1.
RefSeqiNP_001075969.2. NM_001082500.2.
UniGeneiEca.13125.

Genome annotation databases

GeneIDi100064969.
KEGGiecb:100064969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42146 mRNA. Translation: BAA07717.1.
U92480 mRNA. Translation: AAC39255.1.
RefSeqiNP_001075969.2. NM_001082500.2.
UniGeneiEca.13125.

3D structure databases

ProteinModelPortaliQ28385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000021137.

Proteomic databases

PaxDbiQ28385.
PRIDEiQ28385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100064969.
KEGGiecb:100064969.

Organism-specific databases

CTDi3552.

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiQ28385.
KOiK04383.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL1A_HORSE
AccessioniPrimary (citable) accession number: Q28385
Secondary accession number(s): O77743
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.