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Protein

Interferon-induced GTP-binding protein Mx1

Gene

MX1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Interferon-induced dynamin-like GTPase with antiviral activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 84GTPSequence analysis8
Nucleotide bindingi178 – 182GTPSequence analysis5
Nucleotide bindingi247 – 250GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Alternative name(s):
Interferon-regulated resistance GTP-binding protein MxA
Myxoma resistance protein 1
Myxovirus resistance protein 1
Cleaved into the following chain:
Gene namesi
Name:MX1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cytoplasmperinuclear region By similarity

  • Note: Binds preferentially to negatively charged phospholipids.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199531 – 660Interferon-induced GTP-binding protein Mx1Add BLAST660
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00003829422 – 660Interferon-induced GTP-binding protein Mx1, N-terminally processedAdd BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ28379.

Expressioni

Inductioni

By type I and type III interferons.2 Publications

Interactioni

Subunit structurei

Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000010646.

Structurei

3D structure databases

ProteinModelPortaliQ28379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 340Dynamin-type GAdd BLAST274
Domaini572 – 660GEDPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 340GTPase domainBy similarityAdd BLAST272
Regioni341 – 366Bundle signaling element (BSE)By similarityAdd BLAST26
Regioni366 – 533Middle domainBy similarityAdd BLAST168
Regioni367 – 630StalkBy similarityAdd BLAST264
Regioni554 – 557Critical for lipid-bindingBy similarity4

Domaini

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.By similarity
The middle domain mediates self-assembly and oligomerization.By similarity

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiQ28379.
KOiK14754.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHSEAKMTR PDSASASKQQ LLNGNADIQE TNQKRSIEKN LCSQYEEKVR
60 70 80 90 100
PCIDLIDSLR ALGVEQDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG
110 120 130 140 150
IVTRCPLVLK LKRLVKEDEW KGKVSYRDIE VEISNALDVE EQVRKAQNVL
160 170 180 190 200
AGEGVGISQE LVTLEVSSPH VPDLTLIDLP GITRVAVGNQ PADIGRQIKT
210 220 230 240 250
LIRKYIQRQE TINLVVVPSN VDIATTEALS MAQEVDPEGD RTIGILTKPD
260 270 280 290 300
LVDKGTEEQV VDVVRNLICH LKKGYMIVKC RGQQDIQDRL SLAEALQREK
310 320 330 340 350
AFFEENPYFR GLLEEGRASV PCLAERLTTE LITHISKSLP LLENQIKESY
360 370 380 390 400
QNLSDELQKY GTDIPEDETE KTFFLIVKIT TFNQNITSFV QGEELVGPND
410 420 430 440 450
TRLFNKIRQE FQKWSGVIEN NFRKGGEAIR RQIWTFENQY RGRELPGFVN
460 470 480 490 500
YRTFETIIKQ QIQLLEEPAI DMLHRISDLV RDTFTKVSEK NFSEFFNLHR
510 520 530 540 550
TTKSKLEDIK LEQENEAEKS IRLHFQMEKI VYCQDHVYRG TLQKVRENEM
560 570 580 590 600
EEEKKKKTIN VWGQNTSTES SMAEILEHLN AYQHEAGNRL STHIPLIIQF
610 620 630 640 650
FVLQTFGQQL QKSMLQLLQD RDTYDWLLKE RNDTCDKRKF LKERLARLAQ
660
ARRRLAKFPG
Length:660
Mass (Da):75,566
Last modified:November 1, 1996 - v1
Checksum:iB49CD399714C89CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55216 mRNA. Translation: AAC23906.1.
RefSeqiNP_001075961.1. NM_001082492.1.
UniGeneiEca.2265.

Genome annotation databases

GeneIDi100034192.
KEGGiecb:100034192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55216 mRNA. Translation: AAC23906.1.
RefSeqiNP_001075961.1. NM_001082492.1.
UniGeneiEca.2265.

3D structure databases

ProteinModelPortaliQ28379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000010646.

Proteomic databases

PaxDbiQ28379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034192.
KEGGiecb:100034192.

Organism-specific databases

CTDi4599.

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiQ28379.
KOiK14754.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMX1_HORSE
AccessioniPrimary (citable) accession number: Q28379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.