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Protein

Retinol-binding protein 4

Gene

RBP4

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name:
PRBP
Short name:
RBP
Gene namesi
Name:RBP4
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001796019 – 201Retinol-binding protein 4Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 178By similarity
Disulfide bondi88 ↔ 192By similarity
Disulfide bondi138 ↔ 147By similarity
Modified residuei139Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

PaxDbiQ28369.
PeptideAtlasiQ28369.
PRIDEiQ28369.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000013969.

Structurei

3D structure databases

ProteinModelPortaliQ28369.
SMRiQ28369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJHC. Eukaryota.
ENOG4111K1Y. LUCA.
HOGENOMiHOG000293156.
HOVERGENiHBG004493.
InParanoidiQ28369.
KOiK18271.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd/Purpurin.
PANTHERiPTHR11873. PTHR11873. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PIRSF500204. RBP_purpurin. 1 hit.
PRINTSiPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00213. LIPOCALIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWVWALVVL AALGSAGAER DCRVSSFRVK ENFDKARFSG TWYAMAKKDP
60 70 80 90 100
EGLFLQDNIV AEFSVDEYGQ MSATAKGRVR LLNNWDVCAD MVGTFTDTED
110 120 130 140 150
PAKFKMKYWG VASFLQKGND DHWIIDTDYD TYAVQYSCRL LNLDGTCADS
160 170 180 190 200
YSFVFARDPN GFPPEVQRIV RRRQEELCLA RQYRLISHNG YCDGKSDRNL

L
Length:201
Mass (Da):23,022
Last modified:November 1, 1996 - v1
Checksum:i12CF80834E4262DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21208 mRNA. Translation: AAC48461.1.
PIRiI46257.
RefSeqiNP_001075420.1. NM_001081951.1.
UniGeneiEca.1453.

Genome annotation databases

GeneIDi100049790.
KEGGiecb:100049790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21208 mRNA. Translation: AAC48461.1.
PIRiI46257.
RefSeqiNP_001075420.1. NM_001081951.1.
UniGeneiEca.1453.

3D structure databases

ProteinModelPortaliQ28369.
SMRiQ28369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000013969.

Proteomic databases

PaxDbiQ28369.
PeptideAtlasiQ28369.
PRIDEiQ28369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100049790.
KEGGiecb:100049790.

Organism-specific databases

CTDi5950.

Phylogenomic databases

eggNOGiENOG410IJHC. Eukaryota.
ENOG4111K1Y. LUCA.
HOGENOMiHOG000293156.
HOVERGENiHBG004493.
InParanoidiQ28369.
KOiK18271.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd/Purpurin.
PANTHERiPTHR11873. PTHR11873. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PIRSF500204. RBP_purpurin. 1 hit.
PRINTSiPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00213. LIPOCALIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRET4_HORSE
AccessioniPrimary (citable) accession number: Q28369
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: November 1, 1996
Last modified: February 15, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.