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Q28346

- RL4_CANFA

UniProt

Q28346 - RL4_CANFA

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Protein

60S ribosomal protein L4

Gene

RPL4

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L4
Alternative name(s):
60S ribosomal protein L1
Gene namesi
Name:RPL4
Synonyms:RPL1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 42142060S ribosomal protein L4PRO_0000129349Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei14 – 141N6-acetyllysineBy similarity
Modified residuei106 – 1061N6-acetyllysineBy similarity
Modified residuei259 – 2591N6-acetyllysineBy similarity
Modified residuei300 – 3001CitrullineBy similarity
Modified residuei333 – 3331N6-acetyllysineBy similarity
Modified residuei353 – 3531N6-acetyllysineBy similarity
Modified residuei361 – 3611N6-acetyllysineBy similarity
Modified residuei362 – 3621PhosphoserineBy similarity

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

PaxDbiQ28346.
PRIDEiQ28346.

Interactioni

Subunit structurei

Interacts with RBM3. May bind IPO9 with low affinity (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000025501.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKRelectron microscopy8.70c1-421[»]
ProteinModelPortaliQ28346.
SMRiQ28346. Positions 7-263.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ28346.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 418112Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein L4P family.Curated

Phylogenomic databases

eggNOGiCOG0088.
HOGENOMiHOG000107331.
HOVERGENiHBG001453.
InParanoidiQ28346.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
InterProiIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamiPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
PROSITEiPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28346-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ
60 70 80 90 100
PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR
110 120 130 140 150
MFAPTKTWRR WHRRVNTTQK RYAICSALAC LSLPALVMSK GHRIEEVPEL
160 170 180 190 200
PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI KKVYASQRMR AGKGKMRNRR
210 220 230 240 250
RIQRRGPCII YNEDNGIIKA FRKHPGITLL NVSKLNILKL APGGHVGRFC
260 270 280 290 300
IWTESAFRKL DDLYGTWRKA ASLKSNYNLP MHKMLNTDLS RILKMPRDPR
310 320 330 340 350
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQAKNHKLR
360 370 380 390 400
MDKAAAALEA KSEEKGVPGK KPRRKKGKKT VGVKKPKKPV VGKKAAATKK
410 420
PAADKKPAEK KPTTEEKKPA A
Length:421
Mass (Da):47,515
Last modified:January 23, 2007 - v2
Checksum:iAF08C4DDA50A435B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99909 mRNA. Translation: CAA68182.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99909 mRNA. Translation: CAA68182.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ZKR electron microscopy 8.70 c 1-421 [» ]
ProteinModelPortali Q28346.
SMRi Q28346. Positions 7-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000025501.

Proteomic databases

PaxDbi Q28346.
PRIDEi Q28346.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0088.
HOGENOMi HOG000107331.
HOVERGENi HBG001453.
InParanoidi Q28346.

Miscellaneous databases

EvolutionaryTracei Q28346.

Family and domain databases

Gene3Di 3.40.1370.10. 1 hit.
InterProi IPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view ]
Pfami PF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view ]
SUPFAMi SSF52166. SSF52166. 1 hit.
PROSITEi PS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sandholzer U.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-421.
    Strain: Mongrel.
  2. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (8.7 ANGSTROMS).

Entry informationi

Entry nameiRL4_CANFA
AccessioniPrimary (citable) accession number: Q28346
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3