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Q28346 (RL4_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L4
Alternative name(s):
60S ribosomal protein L1
Gene names
Name:RPL4
Synonyms:RPL1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with RBM3. May bind IPO9 with low affinity By similarity.

Post-translational modification

Citrullinated by PADI4 By similarity.

Sequence similarities

Belongs to the ribosomal protein L4P family.

Ontologies

Keywords
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMAcetylation
Citrullination
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 42142060S ribosomal protein L4
PRO_0000129349

Regions

Compositional bias307 – 418112Lys-rich

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue141N6-acetyllysine By similarity
Modified residue1061N6-acetyllysine By similarity
Modified residue2591N6-acetyllysine By similarity
Modified residue3001Citrulline By similarity
Modified residue3331N6-acetyllysine By similarity
Modified residue3531N6-acetyllysine By similarity
Modified residue3611N6-acetyllysine By similarity
Modified residue3621Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28346 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: AF08C4DDA50A435B

FASTA42147,515
        10         20         30         40         50         60 
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH 

        70         80         90        100        110        120 
QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR MFAPTKTWRR WHRRVNTTQK 

       130        140        150        160        170        180 
RYAICSALAC LSLPALVMSK GHRIEEVPEL PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI 

       190        200        210        220        230        240 
KKVYASQRMR AGKGKMRNRR RIQRRGPCII YNEDNGIIKA FRKHPGITLL NVSKLNILKL 

       250        260        270        280        290        300 
APGGHVGRFC IWTESAFRKL DDLYGTWRKA ASLKSNYNLP MHKMLNTDLS RILKMPRDPR 

       310        320        330        340        350        360 
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQAKNHKLR MDKAAAALEA 

       370        380        390        400        410        420 
KSEEKGVPGK KPRRKKGKKT VGVKKPKKPV VGKKAAATKK PAADKKPAEK KPTTEEKKPA 


A 

« Hide

References

[1]Sandholzer U.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-421.
Strain: Mongrel.
[2]"Structure of the mammalian 80S ribosome at 8.7 A resolution."
Chandramouli P., Topf M., Menetret J.F., Eswar N., Cannone J.J., Gutell R.R., Sali A., Akey C.W.
Structure 16:535-548(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (8.7 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X99909 mRNA. Translation: CAA68182.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKRelectron microscopy8.70c1-421[»]
ProteinModelPortalQ28346.
SMRQ28346. Positions 7-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000025501.

Proteomic databases

PaxDbQ28346.
PRIDEQ28346.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0088.
HOGENOMHOG000107331.
HOVERGENHBG001453.
InParanoidQ28346.

Family and domain databases

Gene3D3.40.1370.10. 1 hit.
InterProIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMSSF52166. SSF52166. 1 hit.
PROSITEPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ28346.

Entry information

Entry nameRL4_CANFA
AccessionPrimary (citable) accession number: Q28346
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references