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Reviewed, UniProtKB/Swiss-Prot Q28314 (NOS2_CAPHI)

Last modified November 25, 2008. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Nitric oxide synthase, inducible
    EC=1.14.13.39
Alternative name(s):
    Inducible NO synthase
      Short name=Inducible NOS
      Short name=iNOS
    NOS type II
Gene names
Name: NOS2
OrganismCapra hircus (Goat)
Taxonomic identifier9925 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Protein attributes

Sequence length110 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

Catalytic activity

L-arginine + n NADPH + m O(2) = citrulline + nitric oxide + n NADP(+).

Cofactor

Heme group By similarity.

Binds 1 FAD By similarity.

Binds 1 FMN By similarity.

Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme By similarity.

Enzyme regulation

Regulated by calcium/calmodulin By similarity.

Subunit structure

Homodimer. Binds SLC9A3R1 By similarity.

Induction

By lipopolysaccharide (LPS).

Sequence similarities

Belongs to the NOS family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›110›110Nitric oxide synthase, inducible
PRO_0000170928

Sites

Metal binding351Iron (heme axial ligand) By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1101

Sequences

Sequence LengthMass (Da)Tools
Q28314-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D72188FB257EC518

FASTA11012,654
        10         20         30         40         50         60 
VEAVTKEIET TGTYQLTGDE LIFATKQAWR NAPRCIGRIQ WSNLQVFDAR SCSTAQEMFE 

        70         80         90        100        110 
HICRHVRYAT NNGNIRSAIT VFPQRSDGKH DFRVWNAQLI RYAGYQMPDG 

« Hide

References

[1]"Differential regulation of inducible nitric oxide synthase production in bovine and caprine macrophages."
Adler H., Adler B., Peveri P., Werner E.R., Wachter H., Peterhans E., Jungi T.W.
J. Infect. Dis. 173:971-978(1996) [PubMed: 8603979] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Peripheral blood monocyte.

Cross-references

Sequence databases

U29085 mRNA. Translation: AAB02338.1.

3D structure databases

HSSPHSSP built from PDB template 4NOS based on UniProtKB P35228.
SMRQ28314. Positions 1-110.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ28314.

Family and domain databases

InterProIPR004030. NO_synthase_oxygenase_reg.
[Graphical view]
Gene3DG3DSA:3.90.340.10. NO_synthase_oxygenase_reg. 1 hit.
PfamPF02898. NO_synthase. 1 hit.
[Graphical view]
PROSITEPS60001. NOS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNOS2_CAPHI
AccessionPrimary (citable) accession number: Q28314
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents