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Protein

Interleukin-1 beta

Gene

IL1B

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei169Important for interaction with integrinBy similarity1
Sitei177Important for interaction with integrinBy similarity1
Sitei179Important for interaction with integrinBy similarity1
Sitei188Important for interaction with integrinBy similarity1
Sitei202Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:IL1B
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152851 – 114By similarityAdd BLAST114
ChainiPRO_0000015286115 – 266Interleukin-1 betaAdd BLAST152

Proteomic databases

PaxDbiQ28292

Interactioni

Subunit structurei

Monomer. Interacts with MEFV. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000010762

Structurei

3D structure databases

ProteinModelPortaliQ28292
SMRiQ28292
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGSZ Eukaryota
ENOG410XU2E LUCA
HOGENOMiHOG000246399
HOVERGENiHBG007328
InParanoidiQ28292

Family and domain databases

InterProiView protein in InterPro
IPR003296 IL-1_beta
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR44849 PTHR44849, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVPELTSE MMAYSSNNEN DLFFEADGPG NDVKCCCQDL NHSSLVDEGI
60 70 80 90 100
QLQVSHQLCN KSLRHFVSVI VALEKLKKPC PQVLQEDDLK SIFCYIFEEE
110 120 130 140 150
PIICKTDADN FMSDAAMQSV DCKLQDISHK YLVLSNSYEL RALHLNGENV
160 170 180 190 200
NKQVVFHMSF VHGDESNNKI PVVLGIKQKN LYLSCVMKDG KPTLQLEKVD
210 220 230 240 250
PKVYPKRKME KRFVFNKIEI KNTVEFESSQ YPNWYISTSQ VEGMPVFLGN
260
TRGGQDITDF TMEFSS
Length:266
Mass (Da):30,259
Last modified:January 9, 2007 - v2
Checksum:i3F7FE73949D1E3D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31 – 32ND → GSN in CAA93909 (Ref. 2) Curated2
Sequence conflicti153Q → A in CAA93909 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ923807 mRNA Translation: ABJ51908.1
Z70047 mRNA Translation: CAA93909.1
UniGeneiCfa.33592

Similar proteinsi

Entry informationi

Entry nameiIL1B_CANLF
AccessioniPrimary (citable) accession number: Q28292
Secondary accession number(s): Q006K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 9, 2007
Last modified: April 25, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health