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Protein

cGMP-gated cation channel alpha-1

Gene

CNGA1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei545 – 5451cGMPSequence analysis
Binding sitei560 – 5601cGMPSequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi486 – 608123cGMPSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport, Vision

Keywords - Ligandi

cGMP, cGMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-gated cation channel alpha-1
Alternative name(s):
Cyclic nucleotide-gated cation channel 1
Cyclic nucleotide-gated channel alpha-1
Short name:
CNG channel alpha-1
Short name:
CNG-1
Short name:
CNG1
Cyclic nucleotide-gated channel, photoreceptor
Rod photoreceptor cGMP-gated channel subunit alpha
Gene namesi
Name:CNGA1
Synonyms:CNCG, CNCG1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 163163CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=H1Sequence analysisAdd
BLAST
Topological domaini185 – 19713ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21619Helical; Name=H2Sequence analysisAdd
BLAST
Topological domaini217 – 24024CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26020Helical; Name=H3Sequence analysisAdd
BLAST
Topological domaini261 – 29838ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 32123Helical; Name=H4Sequence analysisAdd
BLAST
Topological domaini322 – 37352CytoplasmicSequence analysisAdd
BLAST
Transmembranei374 – 39320Helical; Name=H5Sequence analysisAdd
BLAST
Topological domaini394 – 47784ExtracellularSequence analysisAdd
BLAST
Transmembranei478 – 49821Helical; Name=H6Sequence analysisAdd
BLAST
Topological domaini499 – 691193CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691cGMP-gated cation channel alpha-1PRO_0000219307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi424 – 4241N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ28279.

Interactioni

Subunit structurei

Tetramer formed of three CNGA1 and one CNGB1 modulatory subunits.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035274.

Structurei

3D structure databases

ProteinModelPortaliQ28279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili622 – 66544By similarityAdd
BLAST

Domaini

The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ28279.
KOiK04948.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR032945. CNGA1.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10217:SF387. PTHR10217:SF387. 1 hit.
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKNIINTWY SFVNIPNVIV PDIEKEIRRM ENGARSSFSD DDGDDDSASM
60 70 80 90 100
FEESENETPH ARDSCRNNSQ RRDPSQREQY LPGAIALFNV NNSSNKEQEP
110 120 130 140 150
KEKKKKKKEK KSKSGDKNEN KKDSEKKKKK EKEKEKKNKE EKGKDKKEEE
160 170 180 190 200
KKEVMVIDPA GNMYYNWLFC ITLPVMYNWT MVIARACFDE LQSDYLEYWI
210 220 230 240 250
IFDYLSDIVY LLDMFVRTRT GYLEQGLLVR EEAKLIEKYK SNLQFKLDFL
260 270 280 290 300
SVIPTDLLYF KLGWNYPEIR LNRLLRISRM FEFFQRTETR TNYPNIFRIS
310 320 330 340 350
NLVMYIVIII HWNACVYFSI SKAIGFGNDT WVYPDVNDPE FGRLARKYVY
360 370 380 390 400
SLYWSTLTLT TIGETPPPVR DSEYVFVVVD FLIGVLIFAT IVGNIGSMIS
410 420 430 440 450
NMNAARAEFQ ARIDAIKQYM HFRNVSKDME KRVIKWFDYL WTNKKTVDEK
460 470 480 490 500
EVLKYLPDKL RAEIAINVHL DTLKKVRIFA DCEAGLLVEL VLKLQPQVYS
510 520 530 540 550
PGDYICKKGD IGREMYIIKE GKLAVVADDG ITQFVVLSDG SYFGEISILN
560 570 580 590 600
IKGSKAGNRR TANIKSIGYS DLFCLSKDDL MEALTEYPDA KTMLEEKGKQ
610 620 630 640 650
ILMKDGLLDI NIANAGSDPK DLEEKVTRME GSVDLLQTRF ARILAEYESM
660 670 680 690
QQKLKQRLTK VERFLKPIID TEFSALEGTG DESRPLDSTQ D
Length:691
Mass (Da):80,251
Last modified:November 1, 1997 - v1
Checksum:i0775CAA42F065275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99914 Genomic DNA. Translation: CAA68186.1.
U83905 mRNA. Translation: AAB61707.1.
PIRiJC6509.
RefSeqiNP_001003222.1. NM_001003222.1.
XP_005628028.1. XM_005627971.1.
UniGeneiCfa.3753.

Genome annotation databases

GeneIDi403891.
KEGGicfa:403891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99914 Genomic DNA. Translation: CAA68186.1.
U83905 mRNA. Translation: AAB61707.1.
PIRiJC6509.
RefSeqiNP_001003222.1. NM_001003222.1.
XP_005628028.1. XM_005627971.1.
UniGeneiCfa.3753.

3D structure databases

ProteinModelPortaliQ28279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035274.

Proteomic databases

PaxDbiQ28279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403891.
KEGGicfa:403891.

Organism-specific databases

CTDi1259.

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ28279.
KOiK04948.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR032945. CNGA1.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10217:SF387. PTHR10217:SF387. 1 hit.
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNGA1_CANLF
AccessioniPrimary (citable) accession number: Q28279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.