Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-12 subunit beta

Gene

IL12B

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.By similarity
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit beta
Short name:
IL-12B
Alternative name(s):
Cytotoxic lymphocyte maturation factor 40 kDa subunit
Short name:
CLMF p40
IL-12 subunit p40
Gene namesi
Name:IL12B
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001092423 – 329Interleukin-12 subunit betaAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 90PROSITE-ProRule annotation
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi200Interchain (with C-99 in IL12A)PROSITE-ProRule annotation
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28268.

Interactioni

Subunit structurei

Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000025465.

Structurei

3D structure databases

ProteinModelPortaliQ28268.
SMRiQ28268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 106Ig-like C2-typeAdd BLAST78
Domaini238 – 329Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IF5K. Eukaryota.
ENOG410YWXR. LUCA.
HOGENOMiHOG000113027.
HOVERGENiHBG052094.
InParanoidiQ28268.
KOiK05425.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015528. IL-12_beta.
IPR019482. IL-12_beta_cen-dom.
PANTHERiPTHR44982. PTHR44982. 1 hit.
PfamiView protein in Pfam
PF10420. IL12p40_C. 1 hit.
PIRSFiPIRSF038007. IL_12_beta. 1 hit.
PRINTSiPR01928. INTRLEUKN12B.
SMARTiView protein in SMART
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPQQLVISW FSLVLLASSL MTIWELEKDV YVVELDWHPD APGEMVVLTC
60 70 80 90 100
HTPEEDDITW TSAQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGKVLSRS
110 120 130 140 150
LLLIHKKEDG IWSTDILKEQ KESKNKIFLK CEAKNYSGRF TCWWLTAIST
160 170 180 190 200
DLKFSVKSSR GFSDPQGVTC GAVTLSAERV RVDNRDYKKY TVECQEGSAC
210 220 230 240 250
PSAEESLPIE VVVDAIHKLK YENYTSSFFI RDIIKPDPPT NLQLKPLKNS
260 270 280 290 300
RHVEVSWEYP DTWSTPHSYF SLTFCVQAQG KNNREKKDRL CVDKTSAKVV
310 320
CHKDAKIRVQ ARDRYYSSSW SDWASVSCS
Length:329
Mass (Da):37,410
Last modified:November 1, 1997 - v1
Checksum:i79F83ED02B5DA93C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49100 mRNA. Translation: AAA92059.1.
RefSeqiNP_001003292.1. NM_001003292.1.
UniGeneiCfa.3651.

Genome annotation databases

GeneIDi403976.
KEGGicfa:403976.

Similar proteinsi

Entry informationi

Entry nameiIL12B_CANLF
AccessioniPrimary (citable) accession number: Q28268
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 20, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families