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Protein

Vascular cell adhesion protein 1

Gene

VCAM1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular cell adhesion protein 1
Short name:
V-CAM 1
Short name:
VCAM-1
Alternative name(s):
CD_antigen: CD106
Gene namesi
Name:VCAM1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 698674ExtracellularSequence analysisAdd
BLAST
Transmembranei699 – 72022HelicalSequence analysisAdd
BLAST
Topological domaini721 – 73919CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 739715Vascular cell adhesion protein 1PRO_0000014996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 95PROSITE-ProRule annotation
Disulfide bondi52 ↔ 99PROSITE-ProRule annotation
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi137 ↔ 195PROSITE-ProRule annotation
Disulfide bondi246 ↔ 291PROSITE-ProRule annotation
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi335 ↔ 383PROSITE-ProRule annotation
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi534 ↔ 579PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28260.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029643.

Structurei

3D structure databases

ProteinModelPortaliQ28260.
SMRiQ28260. Positions 26-223, 313-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 10581Ig-like C2-type 1Add
BLAST
Domaini109 – 212104Ig-like C2-type 2Add
BLAST
Domaini223 – 30987Ig-like C2-type 3Add
BLAST
Domaini312 – 39988Ig-like C2-type 4Add
BLAST
Domaini408 – 50699Ig-like C2-type 5Add
BLAST
Domaini511 – 59585Ig-like C2-type 6Add
BLAST
Domaini600 – 68485Ig-like C2-type 7Add
BLAST

Domaini

Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIKS. Eukaryota.
ENOG4111F4V. LUCA.
HOGENOMiHOG000004820.
HOVERGENiHBG053965.
InParanoidiQ28260.
KOiK06527.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR003989. VCAM-1.
[Graphical view]
PfamiPF05790. C2-set. 2 hits.
PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01472. ICAMVCAM1.
PR01474. VCAM1.
SMARTiSM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKMVVIFG ASNILWMVFA VSQASKMEIF LEPRVAAQIG DVISLTCSTT
60 70 80 90 100
GCETPSFSWR TQIDSPLNGK VKNEGNNSTL TMDPVSFNNE HAYLCTATCG
110 120 130 140 150
SKKLEKGIQV EIYSFPKDPE IQLSGPLEVG KPVTVTCLVR DVYPFDRLEM
160 170 180 190 200
NLLNGNDLLQ SKDFLEPMEK KSLETKSLEV TFTPTNEDIG KGLVCRAQLH
210 220 230 240 250
MDEIDFEPKE RETTKELQVY ISPRNTFISV TPSMRLQEGG SVTMTCASEG
260 270 280 290 300
LPPPQIFWSK KLDNGNLQLL SGNATLTLIA MRLEDSGTYV CEGVNEVGKD
310 320 330 340 350
GKEVELIVQE KPFTVEISPG PQIIAQIGDS VVLTCGVTDC ESPSFSWRTQ
360 370 380 390 400
IDSPLSGTVK VEGAKSTLTL SPVNLENEHS YLCTVTCGHK KLEKGIKVDL
410 420 430 440 450
YSFPRDPEVE MSGLLVDGNP VTVSCEVPNV YPSDRLEIEL FKGETIIESK
460 470 480 490 500
SFLEDMDKKS LETKSLEMTF IPTTEDTGKV LVCLAKLHID EMEFEPKQRQ
510 520 530 540 550
STQTLYVNVA PRDTTVVVSP SSIVEEGSPV NMTCSSDGLP APNILWSRRL
560 570 580 590 600
SNGRLQSLSE DPILTLTSAK MEDSGIYVCE GINQAGISRK EVELIIQVAP
610 620 630 640 650
KDIQLIAFPS ESVKEGDTVI ISCTCGNVPK TWIILKKKAE TGDTVLKSRD
660 670 680 690 700
GAYTIHKVQL EDAGVYECES KNEAGLQLRS LTLDVKGREN NKDYFSPELL
710 720 730
VLYCASSLII PAIGMIIYFA RRANMKGSYS LVEAQKSKV
Length:739
Mass (Da):81,412
Last modified:November 1, 1996 - v1
Checksum:iBB5DA3853739C615
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32086 mRNA. Translation: AAA84866.1.
RefSeqiNP_001003298.1. NM_001003298.1.
UniGeneiCfa.1941.

Genome annotation databases

GeneIDi403982.
KEGGicfa:403982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32086 mRNA. Translation: AAA84866.1.
RefSeqiNP_001003298.1. NM_001003298.1.
UniGeneiCfa.1941.

3D structure databases

ProteinModelPortaliQ28260.
SMRiQ28260. Positions 26-223, 313-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029643.

Proteomic databases

PaxDbiQ28260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403982.
KEGGicfa:403982.

Organism-specific databases

CTDi7412.

Phylogenomic databases

eggNOGiENOG410IIKS. Eukaryota.
ENOG4111F4V. LUCA.
HOGENOMiHOG000004820.
HOVERGENiHBG053965.
InParanoidiQ28260.
KOiK06527.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR003989. VCAM-1.
[Graphical view]
PfamiPF05790. C2-set. 2 hits.
PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01472. ICAMVCAM1.
PR01474. VCAM1.
SMARTiSM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVCAM1_CANLF
AccessioniPrimary (citable) accession number: Q28260
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.