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Protein

Tumor necrosis factor receptor superfamily member 5

Gene

CD40

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 5
Alternative name(s):
B-cell surface antigen CD40
CD40L receptor
CD_antigen: CD40
Gene namesi
Name:CD40
Synonyms:TNFRSF5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 194174ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Topological domaini216 – 28065CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 280260Tumor necrosis factor receptor superfamily member 5PRO_0000034557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 37PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi41 ↔ 59PROSITE-ProRule annotation
Disulfide bondi62 ↔ 77PROSITE-ProRule annotation
Disulfide bondi83 ↔ 103PROSITE-ProRule annotation
Disulfide bondi105 ↔ 119PROSITE-ProRule annotation
Disulfide bondi111 ↔ 116PROSITE-ProRule annotation
Disulfide bondi125 ↔ 143PROSITE-ProRule annotation
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28203.
PRIDEiQ28203.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027630.

Structurei

3D structure databases

ProteinModelPortaliQ28203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 6036TNFR-Cys 1Add
BLAST
Repeati61 – 10343TNFR-Cys 2Add
BLAST
Repeati104 – 14441TNFR-Cys 3Add
BLAST
Repeati145 – 18743TNFR-Cys 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 2538Poly-Pro

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
HOGENOMiHOG000136317.
HOVERGENiHBG005117.
InParanoidiQ28203.
KOiK03160.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view]
PRINTSiPR01922. TNFACTORR5.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRLPLQCLF WGFFLTAVHS EPATACGEKQ YPVNSLCCDL CPPGQKLVND
60 70 80 90 100
CTEVSKTECQ SCGKGEFLST WNREKYCHEH RYCNPNLGLR IQSEGTLNTD
110 120 130 140 150
TTCVCVEGQH CTSHTCESCT PHSLCLPGFG VKQIATGLLD TVCEPCPLGF
160 170 180 190 200
FSNVSSAFEK CHRWTSCERK GLVEQHVGTN KTDVVCGFQS RMRTLVVIPV
210 220 230 240 250
TMGVLFAVLL VSACIRNITK KRQAKALHPT AERQDPVETI DPEDFPGPHP
260 270 280
PPPVQETLCW CQPVAQEDGK ESRISVQERE
Length:280
Mass (Da):31,062
Last modified:February 26, 2008 - v3
Checksum:i695ED038DCADFE29
GO

Sequence cautioni

The sequence AAC48710.1 differs from that shown. Reason: Frameshift at positions 224 and 253. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021T → I in AAC48710 (PubMed:9135560).Curated
Sequence conflicti230 – 2301T → M in AAC48710 (PubMed:9135560).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134765 mRNA. Translation: AAI34766.1.
U57745 mRNA. Translation: AAC48710.1. Frameshift.
RefSeqiNP_001099081.1. NM_001105611.2.
UniGeneiBt.42498.

Genome annotation databases

GeneIDi286849.
KEGGibta:286849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134765 mRNA. Translation: AAI34766.1.
U57745 mRNA. Translation: AAC48710.1. Frameshift.
RefSeqiNP_001099081.1. NM_001105611.2.
UniGeneiBt.42498.

3D structure databases

ProteinModelPortaliQ28203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027630.

Proteomic databases

PaxDbiQ28203.
PRIDEiQ28203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286849.
KEGGibta:286849.

Organism-specific databases

CTDi958.

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
HOGENOMiHOG000136317.
HOVERGENiHBG005117.
InParanoidiQ28203.
KOiK03160.

Miscellaneous databases

NextBioi20806498.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view]
PRINTSiPR01922. TNFACTORR5.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.
  2. "Cloning, expression and biological function of the bovine CD40 homologue: role in B-lymphocyte growth and differentiation in cattle."
    Hirano A., Brown W.C., Estes D.M.
    Immunology 90:294-300(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-270.
    Tissue: Peripheral blood lymphocyte.

Entry informationi

Entry nameiTNR5_BOVIN
AccessioniPrimary (citable) accession number: Q28203
Secondary accession number(s): A7YWS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 26, 2008
Last modified: May 11, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.