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Protein

Advanced glycosylation end product-specific receptor

Gene

AGER

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Advanced glycosylation end product-specific receptor
Alternative name(s):
Receptor for advanced glycosylation end products
Gene namesi
Name:AGER
Synonyms:RAGE
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 352ExtracellularSequence analysisAdd BLAST330
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 416CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001492223 – 416Advanced glycosylation end product-specific receptorAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi38 ↔ 98PROSITE-ProRule annotation
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi143 ↔ 207PROSITE-ProRule annotation
Disulfide bondi269InterchainPROSITE-ProRule annotation
Disulfide bondi311InterchainPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28173.
PRIDEiQ28173.

Expressioni

Tissue specificityi

Endothelial cells.

Interactioni

Subunit structurei

Interacts with S100B, S100A1, S100A12, S100A14 and APP. Constitutive homodimer; disulfide-linked (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019179.

Structurei

3D structure databases

ProteinModelPortaliQ28173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 115Ig-like V-typeAdd BLAST93
Domaini123 – 220Ig-like C2-type 1Add BLAST98
Domaini238 – 327Ig-like C2-type 2Add BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi391 – 396Poly-Glu6

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT2. Eukaryota.
ENOG4111C4I. LUCA.
HOGENOMiHOG000232122.
HOVERGENiHBG004350.
InParanoidiQ28173.
KOiK19722.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGAVVGAW MLVLSLGGTV TGDQNITARI GKPLVLNCKG APKKPPQQLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGDP WDSVARVLPN GSLLLPAVGI QDEGTFRCRA
110 120 130 140 150
TSRSGKETKS NYRVRVYQIP GKPEIVDPAS ELMAGVPNKV GTCVSEGGYP
160 170 180 190 200
AGTLNWLLDG KTLIPDGKGV SVKEETKRHP KTGLFTLHSE LMVTPARGGA
210 220 230 240 250
LHPTFSCSFT PGLPRRRALH TAPIQLRVWS EHRGGEGPNV DAVPLKEVQL
260 270 280 290 300
VVEPEGGAVA PGGTVTLTCE APAQPPPQIH WIKDGRPLPL PPGPMLLLPE
310 320 330 340 350
VGPEDQGTYS CVATHPSHGP QESRAVSVTI IETGEEGTTA GSVEGPGLET
360 370 380 390 400
LALTLGILGG LGTVALLIGV IVWHRRRQRK GQERKVPENQ EEEEEERAEL
410
NQPEEPEAAE SSTGGP
Length:416
Mass (Da):44,182
Last modified:November 1, 1997 - v1
Checksum:iB703815573E767AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91212 mRNA. Translation: AAA03575.1.
PIRiA42879.
RefSeqiNP_776407.1. NM_173982.3.
UniGeneiBt.103300.

Genome annotation databases

GeneIDi280986.
KEGGibta:280986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91212 mRNA. Translation: AAA03575.1.
PIRiA42879.
RefSeqiNP_776407.1. NM_173982.3.
UniGeneiBt.103300.

3D structure databases

ProteinModelPortaliQ28173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019179.

Proteomic databases

PaxDbiQ28173.
PRIDEiQ28173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280986.
KEGGibta:280986.

Organism-specific databases

CTDi177.

Phylogenomic databases

eggNOGiENOG410IVT2. Eukaryota.
ENOG4111C4I. LUCA.
HOGENOMiHOG000232122.
HOVERGENiHBG004350.
InParanoidiQ28173.
KOiK19722.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAGE_BOVIN
AccessioniPrimary (citable) accession number: Q28173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.