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Protein

Plakophilin-1

Gene

PKP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to play a role in junctional plaques.By similarity

GO - Biological processi

  1. single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-1
Alternative name(s):
Band-6 protein
Short name:
B6P
Gene namesi
Name:PKP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Nucleus By similarity. Cell junctiondesmosome By similarity
Note: Nuclear and associated with desmosomes.By similarity

GO - Cellular componenti

  1. desmosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Plakophilin-1PRO_0000064283Add
BLAST

Proteomic databases

PRIDEiQ28161.

Structurei

3D structure databases

ProteinModelPortaliQ28161.
SMRiQ28161. Positions 245-701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati244 – 27532ARM 1Add
BLAST
Repeati276 – 31742ARM 2Add
BLAST
Repeati318 – 36043ARM 3Add
BLAST
Repeati361 – 41252ARM 4Add
BLAST
Repeati413 – 44331ARM 5Add
BLAST
Repeati505 – 53632ARM 6Add
BLAST
Repeati537 – 58347ARM 7Add
BLAST
Repeati584 – 62946ARM 8Add
BLAST
Repeati630 – 69364ARM 9Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG096389.
InParanoidiQ28161.
KOiK10387.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028432. Plakophilin-1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF3. PTHR10372:SF3. 1 hit.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28161-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK
60 70 80 90 100
RQKSKSSQSS TLSHSNRGSM YDGLADSYNN YGTSSRSSFY SKFQAGSGSW
110 120 130 140 150
GYPIYNGTLK READNRRFSS YSQMESWGRQ YPRGGCTAAG AGSDICFMQK
160 170 180 190 200
IKASRSEPDL YCDPRGTLRK GTLGGKGHKT TQNRYSFYST CSGQKAVKKY
210 220 230 240 250
PGRPPSCTSR QDPVCVPPTS CTKDLSFSHS RASSKICSED IECSGLTIPK
260 270 280 290 300
AVQYLSSQDE KCQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP
310 320 330 340 350
NQNVQQAAAG ALRNLVFRST TNKLETRRQN GIREAVSLLR RTGSTEIQKQ
360 370 380 390 400
LTGLLWNLSS TDELKEELIA EALPVLADRV IIPFSGWCDG NSNLSREPVD
410 420 430 440 450
PEVFFNATGC LRNLSSADVG RQTMRNYTGL IDSLMAYVQN CVAANRCDDK
460 470 480 490 500
SVENCMCVLH NLSYRLDAEV PTRYRQLEYN ARNAYTDKSS TGCFSNKSDR
510 520 530 540 550
MTNNNYDCPL PEEEPNPKGS SWLYHSDAVR TYLNLMGKSK KDATLEACAG
560 570 580 590 600
ALQNLTASKG LMSSGMSQLI GLKEKGLPHI ARLLQSGNSD VVRSGASLLS
610 620 630 640 650
NMSRHPALHR VMGTQVFPEV TRLLTSHTGN TSNSEDILAS ACYTVRNLMA
660 670 680 690 700
SLPGMAKQHF SSSMVNNIIN LCRSSTSPKA AEAARLLLSD MWSSRELQGL
710 720
LRQQGFDRSM LGTLAGANSL RNFTSRF
Length:727
Mass (Da):80,180
Last modified:November 1, 1996 - v1
Checksum:i3A27979279BCCEDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37975 mRNA. Translation: CAA86029.1.
RefSeqiNP_776570.1. NM_174145.2.
UniGeneiBt.305.

Genome annotation databases

GeneIDi281405.
KEGGibta:281405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37975 mRNA. Translation: CAA86029.1.
RefSeqiNP_776570.1. NM_174145.2.
UniGeneiBt.305.

3D structure databases

ProteinModelPortaliQ28161.
SMRiQ28161. Positions 245-701.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ28161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281405.
KEGGibta:281405.

Organism-specific databases

CTDi5317.

Phylogenomic databases

HOVERGENiHBG096389.
InParanoidiQ28161.
KOiK10387.

Miscellaneous databases

NextBioi20805395.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028432. Plakophilin-1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF3. PTHR10372:SF3. 1 hit.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein)."
    Heid H.W., Schmidt A., Zimbelmann R., Schaefer S., Winter-Simanowski S., Stumpp S., Keith M., Figge U., Schnolzer M., Franke W.W.
    Differentiation 58:113-131(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPKP1_BOVIN
AccessioniPrimary (citable) accession number: Q28161
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.