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Q28161

- PKP1_BOVIN

UniProt

Q28161 - PKP1_BOVIN

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Protein
Plakophilin-1
Gene
PKP1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to play a role in junctional plaques By similarity.

GO - Biological processi

  1. single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-1
Alternative name(s):
Band-6 protein
Short name:
B6P
Gene namesi
Name:PKP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Nucleus By similarity. Cell junctiondesmosome By similarity
Note: Nuclear and associated with desmosomes By similarity.

GO - Cellular componenti

  1. desmosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Plakophilin-1
PRO_0000064283Add
BLAST

Proteomic databases

PRIDEiQ28161.

Structurei

3D structure databases

ProteinModelPortaliQ28161.
SMRiQ28161. Positions 245-701.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati244 – 27532ARM 1
Add
BLAST
Repeati276 – 31742ARM 2
Add
BLAST
Repeati318 – 36043ARM 3
Add
BLAST
Repeati361 – 41252ARM 4
Add
BLAST
Repeati413 – 44331ARM 5
Add
BLAST
Repeati505 – 53632ARM 6
Add
BLAST
Repeati537 – 58347ARM 7
Add
BLAST
Repeati584 – 62946ARM 8
Add
BLAST
Repeati630 – 69364ARM 9
Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 9 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG096389.
KOiK10387.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028432. Plakophilin-1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF3. PTHR10372:SF3. 1 hit.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28161-1 [UniParc]FASTAAdd to Basket

« Hide

MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK    50
RQKSKSSQSS TLSHSNRGSM YDGLADSYNN YGTSSRSSFY SKFQAGSGSW 100
GYPIYNGTLK READNRRFSS YSQMESWGRQ YPRGGCTAAG AGSDICFMQK 150
IKASRSEPDL YCDPRGTLRK GTLGGKGHKT TQNRYSFYST CSGQKAVKKY 200
PGRPPSCTSR QDPVCVPPTS CTKDLSFSHS RASSKICSED IECSGLTIPK 250
AVQYLSSQDE KCQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP 300
NQNVQQAAAG ALRNLVFRST TNKLETRRQN GIREAVSLLR RTGSTEIQKQ 350
LTGLLWNLSS TDELKEELIA EALPVLADRV IIPFSGWCDG NSNLSREPVD 400
PEVFFNATGC LRNLSSADVG RQTMRNYTGL IDSLMAYVQN CVAANRCDDK 450
SVENCMCVLH NLSYRLDAEV PTRYRQLEYN ARNAYTDKSS TGCFSNKSDR 500
MTNNNYDCPL PEEEPNPKGS SWLYHSDAVR TYLNLMGKSK KDATLEACAG 550
ALQNLTASKG LMSSGMSQLI GLKEKGLPHI ARLLQSGNSD VVRSGASLLS 600
NMSRHPALHR VMGTQVFPEV TRLLTSHTGN TSNSEDILAS ACYTVRNLMA 650
SLPGMAKQHF SSSMVNNIIN LCRSSTSPKA AEAARLLLSD MWSSRELQGL 700
LRQQGFDRSM LGTLAGANSL RNFTSRF 727
Length:727
Mass (Da):80,180
Last modified:November 1, 1996 - v1
Checksum:i3A27979279BCCEDF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37975 mRNA. Translation: CAA86029.1.
RefSeqiNP_776570.1. NM_174145.2.
UniGeneiBt.305.

Genome annotation databases

GeneIDi281405.
KEGGibta:281405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37975 mRNA. Translation: CAA86029.1 .
RefSeqi NP_776570.1. NM_174145.2.
UniGenei Bt.305.

3D structure databases

ProteinModelPortali Q28161.
SMRi Q28161. Positions 245-701.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q28161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281405.
KEGGi bta:281405.

Organism-specific databases

CTDi 5317.

Phylogenomic databases

HOVERGENi HBG096389.
KOi K10387.

Miscellaneous databases

NextBioi 20805395.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028432. Plakophilin-1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view ]
PANTHERi PTHR10372. PTHR10372. 1 hit.
PTHR10372:SF3. PTHR10372:SF3. 1 hit.
Pfami PF00514. Arm. 1 hit.
[Graphical view ]
SMARTi SM00185. ARM. 5 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein)."
    Heid H.W., Schmidt A., Zimbelmann R., Schaefer S., Winter-Simanowski S., Stumpp S., Keith M., Figge U., Schnolzer M., Franke W.W.
    Differentiation 58:113-131(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPKP1_BOVIN
AccessioniPrimary (citable) accession number: Q28161
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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