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Q28161

- PKP1_BOVIN

UniProt

Q28161 - PKP1_BOVIN

Protein

Plakophilin-1

Gene

PKP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Seems to play a role in junctional plaques.By similarity

    GO - Biological processi

    1. single organismal cell-cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plakophilin-1
    Alternative name(s):
    Band-6 protein
    Short name:
    B6P
    Gene namesi
    Name:PKP1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Nucleus By similarity. Cell junctiondesmosome By similarity
    Note: Nuclear and associated with desmosomes.By similarity

    GO - Cellular componenti

    1. desmosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 727727Plakophilin-1PRO_0000064283Add
    BLAST

    Proteomic databases

    PRIDEiQ28161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28161.
    SMRiQ28161. Positions 245-701.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati244 – 27532ARM 1Add
    BLAST
    Repeati276 – 31742ARM 2Add
    BLAST
    Repeati318 – 36043ARM 3Add
    BLAST
    Repeati361 – 41252ARM 4Add
    BLAST
    Repeati413 – 44331ARM 5Add
    BLAST
    Repeati505 – 53632ARM 6Add
    BLAST
    Repeati537 – 58347ARM 7Add
    BLAST
    Repeati584 – 62946ARM 8Add
    BLAST
    Repeati630 – 69364ARM 9Add
    BLAST

    Sequence similaritiesi

    Belongs to the beta-catenin family.Curated
    Contains 9 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG096389.
    KOiK10387.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR028432. Plakophilin-1.
    IPR028435. Plakophilin/d_Catenin.
    [Graphical view]
    PANTHERiPTHR10372. PTHR10372. 1 hit.
    PTHR10372:SF3. PTHR10372:SF3. 1 hit.
    PfamiPF00514. Arm. 1 hit.
    [Graphical view]
    SMARTiSM00185. ARM. 5 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q28161-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK    50
    RQKSKSSQSS TLSHSNRGSM YDGLADSYNN YGTSSRSSFY SKFQAGSGSW 100
    GYPIYNGTLK READNRRFSS YSQMESWGRQ YPRGGCTAAG AGSDICFMQK 150
    IKASRSEPDL YCDPRGTLRK GTLGGKGHKT TQNRYSFYST CSGQKAVKKY 200
    PGRPPSCTSR QDPVCVPPTS CTKDLSFSHS RASSKICSED IECSGLTIPK 250
    AVQYLSSQDE KCQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP 300
    NQNVQQAAAG ALRNLVFRST TNKLETRRQN GIREAVSLLR RTGSTEIQKQ 350
    LTGLLWNLSS TDELKEELIA EALPVLADRV IIPFSGWCDG NSNLSREPVD 400
    PEVFFNATGC LRNLSSADVG RQTMRNYTGL IDSLMAYVQN CVAANRCDDK 450
    SVENCMCVLH NLSYRLDAEV PTRYRQLEYN ARNAYTDKSS TGCFSNKSDR 500
    MTNNNYDCPL PEEEPNPKGS SWLYHSDAVR TYLNLMGKSK KDATLEACAG 550
    ALQNLTASKG LMSSGMSQLI GLKEKGLPHI ARLLQSGNSD VVRSGASLLS 600
    NMSRHPALHR VMGTQVFPEV TRLLTSHTGN TSNSEDILAS ACYTVRNLMA 650
    SLPGMAKQHF SSSMVNNIIN LCRSSTSPKA AEAARLLLSD MWSSRELQGL 700
    LRQQGFDRSM LGTLAGANSL RNFTSRF 727
    Length:727
    Mass (Da):80,180
    Last modified:November 1, 1996 - v1
    Checksum:i3A27979279BCCEDF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z37975 mRNA. Translation: CAA86029.1.
    RefSeqiNP_776570.1. NM_174145.2.
    UniGeneiBt.305.

    Genome annotation databases

    GeneIDi281405.
    KEGGibta:281405.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z37975 mRNA. Translation: CAA86029.1 .
    RefSeqi NP_776570.1. NM_174145.2.
    UniGenei Bt.305.

    3D structure databases

    ProteinModelPortali Q28161.
    SMRi Q28161. Positions 245-701.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q28161.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281405.
    KEGGi bta:281405.

    Organism-specific databases

    CTDi 5317.

    Phylogenomic databases

    HOVERGENi HBG096389.
    KOi K10387.

    Miscellaneous databases

    NextBioi 20805395.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR028432. Plakophilin-1.
    IPR028435. Plakophilin/d_Catenin.
    [Graphical view ]
    PANTHERi PTHR10372. PTHR10372. 1 hit.
    PTHR10372:SF3. PTHR10372:SF3. 1 hit.
    Pfami PF00514. Arm. 1 hit.
    [Graphical view ]
    SMARTi SM00185. ARM. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein)."
      Heid H.W., Schmidt A., Zimbelmann R., Schaefer S., Winter-Simanowski S., Stumpp S., Keith M., Figge U., Schnolzer M., Franke W.W.
      Differentiation 58:113-131(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPKP1_BOVIN
    AccessioniPrimary (citable) accession number: Q28161
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3