Q28161 (PKP1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plakophilin-1

Alternative name(s):
Band-6 protein
Short name=B6P

Gene names

Name:

PKP1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	727 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Seems to play a role in junctional plaques By similarity.
Subcellular location	Nucleus By similarity. Cell junction › desmosome By similarity. Note: Nuclear and associated with desmosomes By similarity.
Sequence similarities	Belongs to the beta-catenin family. Contains 9 ARM repeats.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Nucleus
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	desmosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 727	727	Plakophilin-1		PRO_0000064283
Regions
	Repeat	244 – 275	32	ARM 1
	Repeat	276 – 317	42	ARM 2
	Repeat	318 – 360	43	ARM 3
	Repeat	361 – 412	52	ARM 4
	Repeat	413 – 443	31	ARM 5
	Repeat	505 – 536	32	ARM 6
	Repeat	537 – 583	47	ARM 7
	Repeat	584 – 629	46	ARM 8
	Repeat	630 – 693	64	ARM 9
Amino acid modifications
	Modified residue	65	1	Phosphoserine By similarity
	Modified residue	156	1	Phosphoserine By similarity
	Modified residue	206	1	Phosphoserine By similarity
	Modified residue	226	1	Phosphoserine By similarity
	Modified residue	230	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q28161 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3A27979279BCCEDF	FASTA	727	80,180
	10 20 30 40 50 60 MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQSS 70 80 90 100 110 120 TLSHSNRGSM YDGLADSYNN YGTSSRSSFY SKFQAGSGSW GYPIYNGTLK READNRRFSS 130 140 150 160 170 180 YSQMESWGRQ YPRGGCTAAG AGSDICFMQK IKASRSEPDL YCDPRGTLRK GTLGGKGHKT 190 200 210 220 230 240 TQNRYSFYST CSGQKAVKKY PGRPPSCTSR QDPVCVPPTS CTKDLSFSHS RASSKICSED 250 260 270 280 290 300 IECSGLTIPK AVQYLSSQDE KCQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP 310 320 330 340 350 360 NQNVQQAAAG ALRNLVFRST TNKLETRRQN GIREAVSLLR RTGSTEIQKQ LTGLLWNLSS 370 380 390 400 410 420 TDELKEELIA EALPVLADRV IIPFSGWCDG NSNLSREPVD PEVFFNATGC LRNLSSADVG 430 440 450 460 470 480 RQTMRNYTGL IDSLMAYVQN CVAANRCDDK SVENCMCVLH NLSYRLDAEV PTRYRQLEYN 490 500 510 520 530 540 ARNAYTDKSS TGCFSNKSDR MTNNNYDCPL PEEEPNPKGS SWLYHSDAVR TYLNLMGKSK 550 560 570 580 590 600 KDATLEACAG ALQNLTASKG LMSSGMSQLI GLKEKGLPHI ARLLQSGNSD VVRSGASLLS 610 620 630 640 650 660 NMSRHPALHR VMGTQVFPEV TRLLTSHTGN TSNSEDILAS ACYTVRNLMA SLPGMAKQHF 670 680 690 700 710 720 SSSMVNNIIN LCRSSTSPKA AEAARLLLSD MWSSRELQGL LRQQGFDRSM LGTLAGANSL RNFTSRF

References

[1]

"Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein)." Heid H.W., Schmidt A., Zimbelmann R., Schaefer S., Winter-Simanowski S., Stumpp S., Keith M., Figge U., Schnolzer M., Franke W.W. Differentiation 58:113-131(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z37975 mRNA. Translation: CAA86029.1.
IPI	IPI00716942.
RefSeq	NP_776570.1. NM_174145.2.
UniGene	Bt.305.
3D structure databases
ProteinModelPortal	Q28161.
SMR	Q28161. Positions 245-701.
ModBase	Search...
Proteomic databases
PRIDE	Q28161.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	281405.
KEGG	bta:281405.
Organism-specific databases
CTD	5317.
Phylogenomic databases
HOVERGEN	HBG096389.
KO	K10387.
Family and domain databases
Gene3D	1.25.10.10. 2 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. [Graphical view]
Pfam	PF00514. Arm. 1 hit. [Graphical view]
SMART	SM00185. ARM. 5 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805395.

Entry information

Entry name

PKP1_BOVIN

Accession

Primary (citable) accession number: Q28161

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program