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Q28161 (PKP1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plakophilin-1
Alternative name(s):
Band-6 protein
Short name=B6P
Gene names
Name:PKP1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length727 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to play a role in junctional plaques By similarity.

Subcellular location

Nucleus By similarity. Cell junctiondesmosome By similarity. Note: Nuclear and associated with desmosomes By similarity.

Sequence similarities

Belongs to the beta-catenin family.

Contains 9 ARM repeats.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell junction
Nucleus
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsingle organismal cell-cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentdesmosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 727727Plakophilin-1
PRO_0000064283

Regions

Repeat244 – 27532ARM 1
Repeat276 – 31742ARM 2
Repeat318 – 36043ARM 3
Repeat361 – 41252ARM 4
Repeat413 – 44331ARM 5
Repeat505 – 53632ARM 6
Repeat537 – 58347ARM 7
Repeat584 – 62946ARM 8
Repeat630 – 69364ARM 9

Sequences

Sequence LengthMass (Da)Tools
Q28161 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3A27979279BCCEDF

FASTA72780,180
        10         20         30         40         50         60 
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQSS 

        70         80         90        100        110        120 
TLSHSNRGSM YDGLADSYNN YGTSSRSSFY SKFQAGSGSW GYPIYNGTLK READNRRFSS 

       130        140        150        160        170        180 
YSQMESWGRQ YPRGGCTAAG AGSDICFMQK IKASRSEPDL YCDPRGTLRK GTLGGKGHKT 

       190        200        210        220        230        240 
TQNRYSFYST CSGQKAVKKY PGRPPSCTSR QDPVCVPPTS CTKDLSFSHS RASSKICSED 

       250        260        270        280        290        300 
IECSGLTIPK AVQYLSSQDE KCQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP 

       310        320        330        340        350        360 
NQNVQQAAAG ALRNLVFRST TNKLETRRQN GIREAVSLLR RTGSTEIQKQ LTGLLWNLSS 

       370        380        390        400        410        420 
TDELKEELIA EALPVLADRV IIPFSGWCDG NSNLSREPVD PEVFFNATGC LRNLSSADVG 

       430        440        450        460        470        480 
RQTMRNYTGL IDSLMAYVQN CVAANRCDDK SVENCMCVLH NLSYRLDAEV PTRYRQLEYN 

       490        500        510        520        530        540 
ARNAYTDKSS TGCFSNKSDR MTNNNYDCPL PEEEPNPKGS SWLYHSDAVR TYLNLMGKSK 

       550        560        570        580        590        600 
KDATLEACAG ALQNLTASKG LMSSGMSQLI GLKEKGLPHI ARLLQSGNSD VVRSGASLLS 

       610        620        630        640        650        660 
NMSRHPALHR VMGTQVFPEV TRLLTSHTGN TSNSEDILAS ACYTVRNLMA SLPGMAKQHF 

       670        680        690        700        710        720 
SSSMVNNIIN LCRSSTSPKA AEAARLLLSD MWSSRELQGL LRQQGFDRSM LGTLAGANSL 


RNFTSRF 

« Hide

References

[1]"Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein)."
Heid H.W., Schmidt A., Zimbelmann R., Schaefer S., Winter-Simanowski S., Stumpp S., Keith M., Figge U., Schnolzer M., Franke W.W.
Differentiation 58:113-131(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z37975 mRNA. Translation: CAA86029.1.
RefSeqNP_776570.1. NM_174145.2.
UniGeneBt.305.

3D structure databases

ProteinModelPortalQ28161.
SMRQ28161. Positions 245-701.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ28161.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281405.
KEGGbta:281405.

Organism-specific databases

CTD5317.

Phylogenomic databases

HOVERGENHBG096389.
KOK10387.

Family and domain databases

Gene3D1.25.10.10. 2 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028432. Plakophilin-1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF3. PTHR10372:SF3. 1 hit.
PfamPF00514. Arm. 1 hit.
[Graphical view]
SMARTSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805395.

Entry information

Entry namePKP1_BOVIN
AccessionPrimary (citable) accession number: Q28161
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families