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Protein

Chymotrypsin-like elastase family member 1

Gene

CELA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts upon elastin.

Catalytic activityi

Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71Charge relay systemBy similarity1
Metal bindingi85CalciumBy similarity1
Metal bindingi90Calcium; via carbonyl oxygenBy similarity1
Metal bindingi95CalciumBy similarity1
Active sitei119Charge relay systemBy similarity1
Active sitei214Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandCalcium, Metal-binding

Protein family/group databases

MEROPSiS01.153.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 1 (EC:3.4.21.36)
Alternative name(s):
Elastase I
Elastase-1
Gene namesi
Name:CELA1
Synonyms:ELA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000002767117 – 26Activation peptideBy similarity10
ChainiPRO_000002767227 – 266Chymotrypsin-like elastase family member 1Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 72PROSITE-ProRule annotation
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 220PROSITE-ProRule annotation
Disulfide bondi184 ↔ 200PROSITE-ProRule annotation
Disulfide bondi210 ↔ 240PROSITE-ProRule annotation
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ28153.
PRIDEiQ28153.

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiENSBTAG00000008900.

Interactioni

Protein-protein interaction databases

BioGridi158500. 1 interactor.
STRINGi9913.ENSBTAP00000011718.

Structurei

3D structure databases

ProteinModelPortaliQ28153.
SMRiQ28153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 264Peptidase S1PROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
InParanoidiQ28153.
KOiK01326.
OMAiNSWPSQI.
OrthoDBiEOG091G0DF7.
TreeFamiTF330455.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLLVFTSL VLYGHSTQDF PETNARVVGG TAVSKNSWPS QISLQYKSGS
60 70 80 90 100
SWYHTCGGTL IKQKWVMTAA HCVDSQMTFR VVLGDHNLSQ NDGTEQYISV
110 120 130 140 150
QKIVVHPSWN SNNVAAGYDI AVLRLAQSAT LNSYVQLGVL PQSGTILANN
160 170 180 190 200
TPCYITGWGR TKTNGQLAQT LQQAYLPSVD YATCSSSSYW GSTVKTTMVC
210 220 230 240 250
AGGDGVRAGC QGDSGGPLHC LVNGQYAVHG VTSFVSSLGC NVSKKPTVFT
260
RVSAYISWIN NAIASN
Length:266
Mass (Da):28,518
Last modified:November 1, 1997 - v1
Checksum:i927E29C69BAF67E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80838 mRNA. Translation: AAA98525.1.
BC149525 mRNA. Translation: AAI49526.1.
RefSeqiNP_776473.1. NM_174048.2.
XP_005206313.1. XM_005206256.3.
UniGeneiBt.4522.

Genome annotation databases

EnsembliENSBTAT00000011718; ENSBTAP00000011718; ENSBTAG00000008900.
GeneIDi281139.
KEGGibta:281139.

Similar proteinsi

Entry informationi

Entry nameiCELA1_BOVIN
AccessioniPrimary (citable) accession number: Q28153
Secondary accession number(s): A6QPW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 7, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families