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Protein

Neurexin-1

Gene

NRXN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca2+-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi345Calcium 11 Publication1
Metal bindingi362Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi430Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi788Calcium 21 Publication1
Metal bindingi805Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi864Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi1199Calcium 3By similarity1
Metal bindingi1216Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi1298Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi1300Calcium 3By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • neuroligin family protein binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-1
Alternative name(s):
Neurexin I-alpha
Neurexin-1-alpha
Gene namesi
Name:NRXN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 1454ExtracellularSequence analysisAdd BLAST1424
Transmembranei1455 – 1475HelicalSequence analysisAdd BLAST21
Topological domaini1476 – 1530CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000001948931 – 1530Neurexin-1Add BLAST1500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi228 ↔ 243By similarity
Disulfide bondi245 ↔ 255By similarity
Disulfide bondi460 ↔ 496
Disulfide bondi666 ↔ 695
Disulfide bondi703 ↔ 714
Glycosylationi705O-linked (Glc...)1 Publication1
Disulfide bondi708 ↔ 723
Disulfide bondi725 ↔ 735
Glycosylationi813N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi906 ↔ 914
Disulfide bondi1075 ↔ 1103
Disulfide bondi1110 ↔ 1121
Disulfide bondi1115 ↔ 1130
Disulfide bondi1132 ↔ 1142
Glycosylationi1246N-linked (GlcNAc...)3 Publications1

Post-translational modificationi

N-glycosylated.
O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ28146.

Interactioni

Subunit structurei

Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer. Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1, NLGN2, NLGN3 and NLGN4; these interactions are calcium-dependent. Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity). Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4 (By similarity). Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain). Alpha-type isoforms interact with alpha-latrotoxin from spider venom. The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. Interacts with SYT13 and SYTL1.By similarity5 Publications

GO - Molecular functioni

  • neuroligin family protein binding Source: BHF-UCL

Protein-protein interaction databases

DIPiDIP-59135N.

Structurei

Secondary structure

11530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi299 – 311Combined sources13
Beta strandi313 – 315Combined sources3
Beta strandi317 – 331Combined sources15
Beta strandi335 – 340Combined sources6
Beta strandi345 – 352Combined sources8
Beta strandi355 – 364Combined sources10
Beta strandi366 – 371Combined sources6
Beta strandi374 – 376Combined sources3
Beta strandi378 – 382Combined sources5
Beta strandi384 – 391Combined sources8
Beta strandi410 – 414Combined sources5
Turni415 – 417Combined sources3
Beta strandi418 – 423Combined sources6
Beta strandi425 – 427Combined sources3
Beta strandi431 – 433Combined sources3
Beta strandi435 – 440Combined sources6
Helixi445 – 447Combined sources3
Beta strandi448 – 450Combined sources3
Beta strandi458 – 470Combined sources13
Helixi475 – 481Combined sources7
Beta strandi486 – 490Combined sources5
Beta strandi505 – 507Combined sources3
Beta strandi509 – 511Combined sources3
Beta strandi514 – 516Combined sources3
Beta strandi522 – 532Combined sources11
Beta strandi538 – 544Combined sources7
Beta strandi563 – 569Combined sources7
Beta strandi572 – 581Combined sources10
Beta strandi583 – 588Combined sources6
Beta strandi595 – 597Combined sources3
Beta strandi599 – 606Combined sources8
Beta strandi609 – 614Combined sources6
Beta strandi617 – 622Combined sources6
Beta strandi624 – 626Combined sources3
Beta strandi636 – 640Combined sources5
Helixi655 – 658Combined sources4
Beta strandi665 – 672Combined sources8
Beta strandi675 – 677Combined sources3
Helixi679 – 682Combined sources4
Turni684 – 687Combined sources4
Beta strandi691 – 694Combined sources4
Helixi702 – 704Combined sources3
Helixi709 – 711Combined sources3
Beta strandi713 – 716Combined sources4
Beta strandi718 – 724Combined sources7
Turni726 – 729Combined sources4
Beta strandi730 – 732Combined sources3
Beta strandi741 – 747Combined sources7
Beta strandi750 – 770Combined sources21
Beta strandi774 – 782Combined sources9
Beta strandi784 – 786Combined sources3
Beta strandi789 – 795Combined sources7
Beta strandi798 – 805Combined sources8
Beta strandi819 – 823Combined sources5
Beta strandi829 – 831Combined sources3
Beta strandi833 – 840Combined sources8
Beta strandi843 – 848Combined sources6
Beta strandi853 – 857Combined sources5
Beta strandi859 – 861Combined sources3
Beta strandi865 – 874Combined sources10
Beta strandi889 – 897Combined sources9
Helixi902 – 907Combined sources6
Beta strandi914 – 916Combined sources3
Beta strandi919 – 921Combined sources3
Beta strandi930 – 932Combined sources3
Beta strandi934 – 936Combined sources3
Beta strandi938 – 942Combined sources5
Beta strandi950 – 957Combined sources8
Beta strandi963 – 971Combined sources9
Beta strandi975 – 981Combined sources7
Beta strandi984 – 993Combined sources10
Beta strandi995 – 999Combined sources5
Beta strandi1008 – 1010Combined sources3
Beta strandi1012 – 1018Combined sources7
Beta strandi1023 – 1028Combined sources6
Beta strandi1031 – 1036Combined sources6
Beta strandi1049 – 1052Combined sources4
Helixi1056 – 1061Combined sources6
Beta strandi1069 – 1071Combined sources3
Beta strandi1074 – 1083Combined sources10
Turni1088 – 1091Combined sources4
Beta strandi1093 – 1102Combined sources10
Beta strandi1114 – 1116Combined sources3
Beta strandi1120 – 1123Combined sources4
Beta strandi1125 – 1131Combined sources7
Turni1133 – 1135Combined sources3
Beta strandi1136 – 1139Combined sources4
Beta strandi1148 – 1161Combined sources14
Helixi1164 – 1166Combined sources3
Beta strandi1170 – 1180Combined sources11
Beta strandi1184 – 1193Combined sources10
Turni1195 – 1197Combined sources3
Beta strandi1200 – 1206Combined sources7
Beta strandi1209 – 1219Combined sources11
Beta strandi1221 – 1224Combined sources4
Beta strandi1232 – 1234Combined sources3
Beta strandi1236 – 1243Combined sources8
Beta strandi1246 – 1251Combined sources6
Beta strandi1257 – 1259Combined sources3
Beta strandi1302 – 1309Combined sources8
Turni1310 – 1313Combined sources4
Beta strandi1318 – 1325Combined sources8
Helixi1330 – 1335Combined sources6
Beta strandi1341 – 1350Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H0BX-ray2.10A/B/C/D295-491[»]
2R16X-ray1.04A737-925[»]
3ASIX-ray2.30A923-1353[»]
3POYX-ray3.02A296-1349[»]
3QCWX-ray2.65A/B31-805[»]
A/B816-1355[»]
3R05X-ray2.95A/B31-1355[»]
ProteinModelPortaliQ28146.
SMRiQ28146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ28146.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 212Laminin G-like 1PROSITE-ProRule annotationAdd BLAST182
Domaini213 – 256EGF-like 1PROSITE-ProRule annotationAdd BLAST44
Domaini299 – 496Laminin G-like 2PROSITE-ProRule annotationAdd BLAST198
Domaini503 – 695Laminin G-like 3PROSITE-ProRule annotationAdd BLAST193
Domaini699 – 736EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini741 – 914Laminin G-like 4PROSITE-ProRule annotationAdd BLAST174
Domaini928 – 1103Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176
Domaini1106 – 1143EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini1149 – 1347Laminin G-like 6PROSITE-ProRule annotationAdd BLAST199

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1377 – 1380Poly-Thr4
Compositional biasi1462 – 1465Poly-Ala4

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 6 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000230481.
HOVERGENiHBG052670.
InParanoidiQ28146.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 4 hits.
PfamiPF00008. EGF. 1 hit.
PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequences (16)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 16 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: Two isoform types, alpha-type and beta-type are produced by alternative promoter usage. In addition there are at least five alternatively spliced sites, each of which may be spliced in up to seven different ways. Combinatorial splicing at each of these five sites may lead to the generation of at least 96 isoforms but for simplicity only individual splice events are explicitly described below. Beta-type isoforms share the possibility of alternative splicing at sites 4 and 5. Experimental confirmation may be lacking for some isoforms.2 Publications
Isoform 1a (identifier: Q28146-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-1A2A3A4A5A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC
60 70 80 90 100
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP
110 120 130 140 150
ATLLTDTPVN DGAWHNVRIR RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF
160 170 180 190 200
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSLALPVDSG
210 220 230 240 250
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF
260 270 280 290 300
RGKDCSQEDN NVEGLAHLMM GDQGKSKEDN NVEGLAHLMM GDQGKEEYIA
310 320 330 340 350
TFKGSEYFCY DLSQNPIQSS SDEITLSFKT LQRNGLMLHT GKSADYVNLA
360 370 380 390 400
LKNGAVSLVI NLGSGAFEAL VEPVNGKFND NAWHDVKVTR NLRQTSGIGH
410 420 430 440 450
AMVNKLHCSV TISVDGILTT TGYTQEDYTM LGSDDFFYVG GSPSTADLPG
460 470 480 490 500
SPVSNNFMGC LKEVVYKNND VRLELSRLAK QGDPKMKIHG VVAFKCENVA
510 520 530 540 550
TLDPITFETP ESFISLPKWN AKKTGSISFD FRTTEPNGLI LFSHGKPRHQ
560 570 580 590 600
KDAKHPQMIK VDFFAIEMLD GHLYLLLDMG SGTIKIKALQ KKVNDGEWYH
610 620 630 640 650
VDFQRDGRSG TISVNTLRTP YTAPGESQIL DLDDELYLGG LPENKAGLVF
660 670 680 690 700
PTEVWTALLN YGYVGCIRDL FIDGQSKDIR QMAEVQSTAG VKPSCSRETA
710 720 730 740 750
KPCLSNPCKN NGMCRDGWNR YVCDCSGTGY LGRSCEREAT VLSYDGSMFM
760 770 780 790 800
KIQLPVVMHT EAEDVSLRFR SQRAYGILMA TTSRDSADTL RLELDAGRVK
810 820 830 840 850
LTVNLDCIRI NCNSSKGPET LFAGYNLNDN EWHTVRVVRR GKSLKLTVDD
860 870 880 890 900
QQAMTGQMAG DHTRLEFHNI ETGIITERRY LSSVPSNFIG HLQSLTFNGM
910 920 930 940 950
AYIDLCKNGD IDYCELNARF GFRNIIADPV TFKTKSSYVA LATLQAYTSM
960 970 980 990 1000
HLFFQFKTTS LDGLILYNSG DGNDFIVVEL VKGYLHYVFD LGNGANLIKG
1010 1020 1030 1040 1050
SSNKPLNDNQ WHNVMISRDT SNLHTVKIDT KITTQITAGA RNLDLKSDLY
1060 1070 1080 1090 1100
IGGVAKETYK SLPKLVHAKE GFQGCLASVD LNGRLPDLIS DALFCNGQIE
1110 1120 1130 1140 1150
RGCEGPSTTC QEDSCSNQGV CLQQWDGISC DCSMTSFSGP LCNDPGTTYI
1160 1170 1180 1190 1200
FSKGGGQITY KWPPNDRPST RADRLAIGFS TVQKEAVLVR VDSSSGLGDY
1210 1220 1230 1240 1250
LELHIHQGKI GVKFNVGTDD IAIEESNAII NDGKYHVVRF TRSGGNATLQ
1260 1270 1280 1290 1300
VDSWPVIERY PAGNNDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN
1310 1320 1330 1340 1350
SQATIIIGGK EQGQPFQGQL SGLYYNGLKV LNMAAENDAN IAIVGNVRLV
1360 1370 1380 1390 1400
GEVPSSMTTE STATAMQSEM STSIMETTTT LATSTARRGK PPTKEPVSQT
1410 1420 1430 1440 1450
TDDILVASAE CPSDDEDIDP CEPSSGGLAN PTRAGGREPY PGSAEVIRES
1460 1470 1480 1490 1500
SSTTGMVVGI VAAAALCILI LLYAMYKYRN RDEGSYHVDE SRNYISNSAQ
1510 1520 1530
SNGAVVKEKQ PSSAKSANKN KKNKDKEYYV
Length:1,530
Mass (Da):167,939
Last modified:November 1, 1996 - v1
Checksum:i8A4E4A75C4EC03D1
GO
Isoform 2a (identifier: Q28146-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1B

The sequence of this isoform differs from the canonical sequence as follows:
     278-293: Missing.

Show »
Length:1,514
Mass (Da):166,184
Checksum:iCD1B8650A183C789
GO
Isoform 3a (identifier: Q28146-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1C

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: Missing.
     278-293: Missing.

Show »
Length:1,513
Mass (Da):166,055
Checksum:i4BF85979B6828A64
GO
Isoform 4a (identifier: Q28146-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-1D

The sequence of this isoform differs from the canonical sequence as follows:
     274-293: Missing.

Show »
Length:1,510
Mass (Da):165,783
Checksum:i999348A15A299E5B
GO
Isoform 5a (identifier: Q28146-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: Missing.
     274-293: Missing.

Show »
Length:1,509
Mass (Da):165,654
Checksum:iDE92054CBD9D8970
GO
Isoform 6a (identifier: Q28146-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-1F

The sequence of this isoform differs from the canonical sequence as follows:
     264-273: Missing.
     278-293: Missing.

Show »
Length:1,504
Mass (Da):165,130
Checksum:i00CF8E297D4306EC
GO
Isoform 7a (identifier: Q28146-7) [UniParc]FASTAAdd to basket
Also known as: Alpha-1G

The sequence of this isoform differs from the canonical sequence as follows:
     258-293: Missing.

Show »
Length:1,494
Mass (Da):164,028
Checksum:i3ACA6902A43B3F36
GO
Isoform 8a (identifier: Q28146-8) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B

The sequence of this isoform differs from the canonical sequence as follows:
     403-409: Missing.

Show »
Length:1,523
Mass (Da):167,157
Checksum:i2A97DE64CF3B1AB8
GO
Isoform 9a (identifier: Q28146-9) [UniParc]FASTAAdd to basket
Also known as: Alpha-2C

The sequence of this isoform differs from the canonical sequence as follows:
     395-409: Missing.

Show »
Length:1,515
Mass (Da):166,402
Checksum:i505A40B67ECA57A8
GO
Isoform 10a (identifier: Q28146-10) [UniParc]FASTAAdd to basket
Also known as: Alpha-3B

The sequence of this isoform differs from the canonical sequence as follows:
     806-815: DCIRINCNSS → G

Show »
Length:1,521
Mass (Da):166,890
Checksum:iB36B0040832AD591
GO
Isoform 11a (identifier: Q28146-11) [UniParc]FASTAAdd to basket
Also known as: Alpha-4B

The sequence of this isoform differs from the canonical sequence as follows:
     1263-1292: Missing.

Show »
Length:1,500
Mass (Da):164,376
Checksum:iFFF0536B1443D542
GO
Isoform 12a (identifier: Q28146-12) [UniParc]FASTAAdd to basket
Also known as: Alpha-5B

The sequence of this isoform differs from the canonical sequence as follows:
     1426-1428: Missing.

Show »
Length:1,527
Mass (Da):167,711
Checksum:i4E97EBE1D1383A03
GO
Isoform 1b (identifier: Q28142-1) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5A
The sequence of this isoform can be found in the external entry Q28142.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:467
Mass (Da):50,084
GO
Isoform 2b (identifier: Q28142-2) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5B
The sequence of this isoform can be found in the external entry Q28142.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:464
Mass (Da):49,857
GO
Isoform 3b (identifier: Q28142-3) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5A
The sequence of this isoform can be found in the external entry Q28142.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:437
Mass (Da):46,521
GO
Isoform 4b (identifier: Q28142-4) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5B
The sequence of this isoform can be found in the external entry Q28142.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:434
Mass (Da):46,294
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003475258 – 293Missing in isoform 7a. CuratedAdd BLAST36
Alternative sequenceiVSP_003474258Missing in isoform 3a and isoform 5a. Curated1
Alternative sequenceiVSP_003476264 – 273Missing in isoform 6a. Curated10
Alternative sequenceiVSP_003477274 – 293Missing in isoform 4a and isoform 5a. CuratedAdd BLAST20
Alternative sequenceiVSP_003478278 – 293Missing in isoform 2a, isoform 3a and isoform 6a. CuratedAdd BLAST16
Alternative sequenceiVSP_003479395 – 409Missing in isoform 9a. CuratedAdd BLAST15
Alternative sequenceiVSP_003480403 – 409Missing in isoform 8a. Curated7
Alternative sequenceiVSP_003481806 – 815DCIRINCNSS → G in isoform 10a. Curated10
Alternative sequenceiVSP_0034821263 – 1292Missing in isoform 11a. CuratedAdd BLAST30
Alternative sequenceiVSP_0034831426 – 1428Missing in isoform 12a. Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14855 mRNA. Translation: AAA74123.1.
PIRiI45944.
RefSeqiNP_776829.1. NM_174404.2. [Q28146-1]
UniGeneiBt.5497.

Genome annotation databases

GeneIDi281950.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14855 mRNA. Translation: AAA74123.1.
PIRiI45944.
RefSeqiNP_776829.1. NM_174404.2. [Q28146-1]
UniGeneiBt.5497.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H0BX-ray2.10A/B/C/D295-491[»]
2R16X-ray1.04A737-925[»]
3ASIX-ray2.30A923-1353[»]
3POYX-ray3.02A296-1349[»]
3QCWX-ray2.65A/B31-805[»]
A/B816-1355[»]
3R05X-ray2.95A/B31-1355[»]
ProteinModelPortaliQ28146.
SMRiQ28146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59135N.

Proteomic databases

PRIDEiQ28146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281950.

Organism-specific databases

CTDi9378.

Phylogenomic databases

HOGENOMiHOG000230481.
HOVERGENiHBG052670.
InParanoidiQ28146.

Miscellaneous databases

EvolutionaryTraceiQ28146.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 4 hits.
PfamiPF00008. EGF. 1 hit.
PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRX1A_BOVIN
AccessioniPrimary (citable) accession number: Q28146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.