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Protein

Neurexin-1-beta

Gene

NRXN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi136CalciumBy similarity1
Metal bindingi153Calcium; via carbonyl oxygenBy similarity1
Metal bindingi235Calcium; via carbonyl oxygenBy similarity1
Metal bindingi237CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-1-beta
Alternative name(s):
Neurexin I-beta
Gene namesi
Name:NRXN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini46 – 391ExtracellularSequence analysisAdd BLAST346
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 467CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 45By similarityAdd BLAST45
ChainiPRO_000001949246 – 467Neurexin-1-betaAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Highly O-glycosylated and minor N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ28142.
PRIDEiQ28142.

Interactioni

Subunit structurei

The cytoplasmic C-terminal region binds to CASK. Isoforms 3b and 4b bind neuroligins NLGN1, NLGN2 and NLGN3, alpha-dystroglycan and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 (By similarity). Interacts with CBLN1, CBLN2 and more weakly with CBLN4. CBLN1-binding is calcium-independent (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053932.

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi86 – 98Combined sources13
Helixi101 – 103Combined sources3
Beta strandi107 – 118Combined sources12
Beta strandi121 – 131Combined sources11
Beta strandi137 – 143Combined sources7
Beta strandi146 – 155Combined sources10
Beta strandi158 – 161Combined sources4
Beta strandi169 – 171Combined sources3
Beta strandi173 – 180Combined sources8
Beta strandi183 – 188Combined sources6
Beta strandi194 – 196Combined sources3
Beta strandi239 – 245Combined sources7
Turni247 – 250Combined sources4
Beta strandi255 – 262Combined sources8
Helixi267 – 272Combined sources6
Beta strandi278 – 286Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VKFX-ray3.30C/D83-290[»]
ProteinModelPortaliQ28142.
SMRiQ28142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 284Laminin G-likePROSITE-ProRule annotationAdd BLAST199

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi314 – 317Poly-Thr4
Compositional biasi399 – 402Poly-Ala4

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
HOVERGENiHBG052670.
KOiK07377.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 2 hits.
PfamiPF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequences (16)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 16 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: A number of isoforms alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. There is a combination of 2 alternatively spliced domains at sites 4 and 5, which are shared with alpha isoforms and which seem to be used independently. Experimental confirmation may be lacking for some isoforms.
Isoform 1b (identifier: Q28142-1) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQRMLRCGA ELGSPGGGGG GAGGRLALLW IVPLTLSGLL GVAWGASSLG
60 70 80 90 100
AHHIHHFHGS SKHHSVPIAI YRSPASLRGG HAGTTYIFSK GGGQITYKWP
110 120 130 140 150
PNDRPSTRAD RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK
160 170 180 190 200
FNVGTDDIAI EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG
210 220 230 240 250
NNDNERLAIA RQRIPYRLGR VVDEWLLDKG RQLTIFNSQA TIIIGGKEQG
260 270 280 290 300
QPFQGQLSGL YYNGLKVLNM AAENDANIAI VGNVRLVGEV PSSMTTESTA
310 320 330 340 350
TAMQSEMSTS IMETTTTLAT STARRGNSPT KEPVSQTTDD ILVASAECPS
360 370 380 390 400
DDEDIDPCEP SSGGLANPTR AGGREPYPGS AEVIRESSST TGMVVGIVAA
410 420 430 440 450
AALCILILLY AMYKYRNRDE GSYHVDESRN YISNSAQSNG AVVKEKQPSS
460
AKSANKNKKN KDKEYYV
Length:467
Mass (Da):50,084
Last modified:November 16, 2001 - v2
Checksum:i70D281E2510AB21E
GO
Isoform 2b (identifier: Q28142-2) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5B

The sequence of this isoform differs from the canonical sequence as follows:
     363-365: Missing.

Show »
Length:464
Mass (Da):49,857
Checksum:i09020D501E83A1F0
GO
Isoform 3b (identifier: Q28142-3) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5A

The sequence of this isoform differs from the canonical sequence as follows:
     201-230: Missing.

Show »
Length:437
Mass (Da):46,521
Checksum:iDF786F815A7B5E03
GO
Isoform 4b (identifier: Q28142-4) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5B

The sequence of this isoform differs from the canonical sequence as follows:
     201-230: Missing.
     363-365: Missing.

Show »
Length:434
Mass (Da):46,294
Checksum:i3A097CBC0353778B
GO
Isoform 1a (identifier: Q28146-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-1A2A3A4A5A
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,530
Mass (Da):167,939
GO
Isoform 2a (identifier: Q28146-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1B
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,514
Mass (Da):166,184
GO
Isoform 3a (identifier: Q28146-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1C
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,513
Mass (Da):166,055
GO
Isoform 4a (identifier: Q28146-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-1D
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,510
Mass (Da):165,783
GO
Isoform 5a (identifier: Q28146-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,509
Mass (Da):165,654
GO
Isoform 6a (identifier: Q28146-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-1F
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,504
Mass (Da):165,130
GO
Isoform 7a (identifier: Q28146-7) [UniParc]FASTAAdd to basket
Also known as: Alpha-1G
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,494
Mass (Da):164,028
GO
Isoform 8a (identifier: Q28146-8) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,523
Mass (Da):167,157
GO
Isoform 9a (identifier: Q28146-9) [UniParc]FASTAAdd to basket
Also known as: Alpha-2C
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,515
Mass (Da):166,402
GO
Isoform 10a (identifier: Q28146-10) [UniParc]FASTAAdd to basket
Also known as: Alpha-3B
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,521
Mass (Da):166,890
GO
Isoform 11a (identifier: Q28146-11) [UniParc]FASTAAdd to basket
Also known as: Alpha-4B
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,500
Mass (Da):164,376
GO
Isoform 12a (identifier: Q28146-12) [UniParc]FASTAAdd to basket
Also known as: Alpha-5B
The sequence of this isoform can be found in the external entry Q28146.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,527
Mass (Da):167,711
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003494201 – 230Missing in isoform 3b and isoform 4b. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_003495363 – 365Missing in isoform 2b and isoform 4b. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27870 mRNA. Translation: AAA19906.1.
RefSeqiNP_001103275.1. NM_001109805.2. [Q28142-3]
UniGeneiBt.5497.

Genome annotation databases

GeneIDi281950.
KEGGibta:281950.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27870 mRNA. Translation: AAA19906.1.
RefSeqiNP_001103275.1. NM_001109805.2. [Q28142-3]
UniGeneiBt.5497.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VKFX-ray3.30C/D83-290[»]
ProteinModelPortaliQ28142.
SMRiQ28142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053932.

Proteomic databases

PaxDbiQ28142.
PRIDEiQ28142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281950.
KEGGibta:281950.

Organism-specific databases

CTDi9378.

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
HOVERGENiHBG052670.
KOiK07377.

Enzyme and pathway databases

ReactomeiR-BTA-6794361. Interactions of neurexins and neuroligins at synapses.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 2 hits.
PfamiPF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRX1B_BOVIN
AccessioniPrimary (citable) accession number: Q28142
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.