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Protein

Allergen Bos d 2

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable pheromone carrier.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Allergen Bos d 2
Alternative name(s):
Dander major allergen BDA20
Dermal allergen BDA20
Allergen: Bos d 2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Potent allergen of bovine dander.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei158. Bos d 2.
159. Bos d 2.0101.
160. Bos d 2.0102.
161. Bos d 2.0103.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000001798317 – 172Allergen Bos d 2Add BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Pyrrolidone carboxylic acid1
Disulfide bondi60 ↔ 64
Disulfide bondi79 ↔ 170

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ28133.
PRIDEiQ28133.

Expressioni

Tissue specificityi

Found exclusively in skin. Produced in sweat glands and transported to the skin surface.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022376.

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 27Combined sources3
Beta strandi28 – 31Combined sources4
Beta strandi33 – 41Combined sources9
Helixi42 – 44Combined sources3
Beta strandi54 – 61Combined sources8
Turni62 – 65Combined sources4
Beta strandi66 – 75Combined sources10
Beta strandi78 – 90Combined sources13
Beta strandi93 – 109Combined sources17
Beta strandi111 – 121Combined sources11
Beta strandi126 – 138Combined sources13
Helixi141 – 153Combined sources13
Helixi158 – 160Combined sources3
Beta strandi161 – 163Combined sources3
Helixi165 – 167Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BJ7X-ray1.80A17-172[»]
4WFUX-ray1.75A17-172[»]
4WFVX-ray1.40A17-172[»]
ProteinModelPortaliQ28133.
SMRiQ28133.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ28133.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFM0. Eukaryota.
ENOG4111E4N. LUCA.
GeneTreeiENSGT00730000111347.
HOVERGENiHBG098951.
InParanoidiQ28133.
OMAiYYRRIEC.
OrthoDBiEOG091G0PVJ.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002448. Odour-bd.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01173. ODORANTBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVFLTLLF GLVCTAQETP AEIDPSKIPG EWRIIYAAAD NKDKIVEGGP
60 70 80 90 100
LRNYYRRIEC INDCESLSIT FYLKDQGTCL LLTEVAKRQE GYVYVLEFYG
110 120 130 140 150
TNTLEVIHVS ENMLVTYVEN YDGERITKMT EGLAKGTSFT PEELEKYQQL
160 170
NSERGVPNEN IENLIKTDNC PP
Length:172
Mass (Da):19,560
Last modified:November 1, 1997 - v1
Checksum:iC50F66F1B3D98156
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42867 mRNA. Translation: AAB08720.1.
PIRiA59225.
B59225.
RefSeqiNP_777186.1. NM_174761.2.
UniGeneiBt.550.

Genome annotation databases

EnsembliENSBTAT00000022376; ENSBTAP00000022376; ENSBTAG00000016820.
GeneIDi286791.
KEGGibta:286791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42867 mRNA. Translation: AAB08720.1.
PIRiA59225.
B59225.
RefSeqiNP_777186.1. NM_174761.2.
UniGeneiBt.550.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BJ7X-ray1.80A17-172[»]
4WFUX-ray1.75A17-172[»]
4WFVX-ray1.40A17-172[»]
ProteinModelPortaliQ28133.
SMRiQ28133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022376.

Protein family/group databases

Allergomei158. Bos d 2.
159. Bos d 2.0101.
160. Bos d 2.0102.
161. Bos d 2.0103.

Proteomic databases

PaxDbiQ28133.
PRIDEiQ28133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022376; ENSBTAP00000022376; ENSBTAG00000016820.
GeneIDi286791.
KEGGibta:286791.

Organism-specific databases

CTDi286791.

Phylogenomic databases

eggNOGiENOG410JFM0. Eukaryota.
ENOG4111E4N. LUCA.
GeneTreeiENSGT00730000111347.
HOVERGENiHBG098951.
InParanoidiQ28133.
OMAiYYRRIEC.
OrthoDBiEOG091G0PVJ.
TreeFamiTF338197.

Miscellaneous databases

EvolutionaryTraceiQ28133.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002448. Odour-bd.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01173. ODORANTBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALL2_BOVIN
AccessioniPrimary (citable) accession number: Q28133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.