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Protein

Allergen Bos d 2

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable pheromone carrier.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Allergen Bos d 2
Alternative name(s):
Dander major allergen BDA20
Dermal allergen BDA20
Allergen: Bos d 2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Potent allergen of bovine dander.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei158. Bos d 2.
159. Bos d 2.0101.
160. Bos d 2.0102.
161. Bos d 2.0103.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Chaini17 – 172156Allergen Bos d 2PRO_0000017983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171Pyrrolidone carboxylic acid
Disulfide bondi60 ↔ 64
Disulfide bondi79 ↔ 170

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ28133.

Expressioni

Tissue specificityi

Found exclusively in skin. Produced in sweat glands and transported to the skin surface.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022376.

Structurei

Secondary structure

1
172
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 273Combined sources
Beta strandi28 – 314Combined sources
Beta strandi33 – 419Combined sources
Helixi42 – 443Combined sources
Beta strandi54 – 618Combined sources
Turni62 – 654Combined sources
Beta strandi66 – 7510Combined sources
Beta strandi78 – 9013Combined sources
Beta strandi93 – 10917Combined sources
Beta strandi111 – 12111Combined sources
Beta strandi126 – 13813Combined sources
Helixi141 – 15313Combined sources
Helixi158 – 1603Combined sources
Beta strandi161 – 1633Combined sources
Helixi165 – 1673Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BJ7X-ray1.80A17-172[»]
4WFUX-ray1.75A17-172[»]
4WFVX-ray1.40A17-172[»]
ProteinModelPortaliQ28133.
SMRiQ28133. Positions 23-172.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ28133.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFM0. Eukaryota.
ENOG4111E4N. LUCA.
GeneTreeiENSGT00730000111347.
HOVERGENiHBG098951.
InParanoidiQ28133.
OMAiYYRRIEC.
OrthoDBiEOG7FFMTG.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002448. Odour-bd.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01173. ODORANTBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVFLTLLF GLVCTAQETP AEIDPSKIPG EWRIIYAAAD NKDKIVEGGP
60 70 80 90 100
LRNYYRRIEC INDCESLSIT FYLKDQGTCL LLTEVAKRQE GYVYVLEFYG
110 120 130 140 150
TNTLEVIHVS ENMLVTYVEN YDGERITKMT EGLAKGTSFT PEELEKYQQL
160 170
NSERGVPNEN IENLIKTDNC PP
Length:172
Mass (Da):19,560
Last modified:November 1, 1997 - v1
Checksum:iC50F66F1B3D98156
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42867 mRNA. Translation: AAB08720.1.
PIRiA59225.
B59225.
RefSeqiNP_777186.1. NM_174761.2.
UniGeneiBt.550.

Genome annotation databases

EnsembliENSBTAT00000022376; ENSBTAP00000022376; ENSBTAG00000016820.
GeneIDi286791.
KEGGibta:286791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42867 mRNA. Translation: AAB08720.1.
PIRiA59225.
B59225.
RefSeqiNP_777186.1. NM_174761.2.
UniGeneiBt.550.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BJ7X-ray1.80A17-172[»]
4WFUX-ray1.75A17-172[»]
4WFVX-ray1.40A17-172[»]
ProteinModelPortaliQ28133.
SMRiQ28133. Positions 23-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022376.

Protein family/group databases

Allergomei158. Bos d 2.
159. Bos d 2.0101.
160. Bos d 2.0102.
161. Bos d 2.0103.

Proteomic databases

PaxDbiQ28133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022376; ENSBTAP00000022376; ENSBTAG00000016820.
GeneIDi286791.
KEGGibta:286791.

Organism-specific databases

CTDi286791.

Phylogenomic databases

eggNOGiENOG410JFM0. Eukaryota.
ENOG4111E4N. LUCA.
GeneTreeiENSGT00730000111347.
HOVERGENiHBG098951.
InParanoidiQ28133.
OMAiYYRRIEC.
OrthoDBiEOG7FFMTG.
TreeFamiTF338197.

Miscellaneous databases

EvolutionaryTraceiQ28133.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002448. Odour-bd.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01173. ODORANTBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complementary DNA cloning of the predominant allergen of bovine dander: a new member in the lipocalin family."
    Maentyjaervi R., Parkkinen S., Rytkoenen M., Pentikaeinen J., Pelkonen J., Rautiainen J., Virtanen T.
    J. Allergy Clin. Immunol. 97:1297-1303(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
    Tissue: Skin.
  2. "A bovine dander allergen, comparative modeling, and similarities and differences in folding with related proteins."
    Santa H., Saarela J.T., Laatikainen R., Rautiainen J., Virtanen T., Rytkonen M., Maentyjaervi R.
    J. Protein Chem. 17:657-662(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  3. "Probing the molecular basis of allergy. three-dimensional structure of the bovine lipocalin allergen Bos d 2."
    Rouvinen J., Rautiainen J., Virtanen T., Zeiler T., Kauppinen J., Taivainen A., Maentyjaervi R.
    J. Biol. Chem. 274:2337-2343(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
  4. "Molecular and crystal properties of Bos d 2, an allergenic protein of the lipocalin family."
    Rautiainen J., Auriola S., Rouvinen J., Kauppinen J., Zeiler T., Novikov D., Virtanen T., Maentyjaervi R.A.
    Biochem. Biophys. Res. Commun. 247:746-750(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, CRYSTALLIZATION.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiALL2_BOVIN
AccessioniPrimary (citable) accession number: Q28133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.