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Q28125 (ICAM3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Intercellular adhesion molecule 3

Short name=ICAM-3
Alternative name(s):
CD_antigen=CD50
Gene names
Name:ICAM3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length544 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell-cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 544513Intercellular adhesion molecule 3
PRO_0000014793

Regions

Topological domain32 – 486455Extracellular Potential
Transmembrane487 – 51125Helical; Potential
Topological domain512 – 54433Cytoplasmic Potential
Domain48 – 10558Ig-like C2-type 1
Domain134 – 20067Ig-like C2-type 2
Domain237 – 30266Ig-like C2-type 3
Domain330 – 38354Ig-like C2-type 4
Domain417 – 47054Ig-like C2-type 5

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation2091N-linked (GlcNAc...) Potential
Glycosylation2431N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation3261N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential
Glycosylation4561N-linked (GlcNAc...) Potential
Disulfide bond55 ↔ 98 Potential
Disulfide bond141 ↔ 193 Potential
Disulfide bond244 ↔ 295 Potential
Disulfide bond337 ↔ 376 Potential
Disulfide bond424 ↔ 463 Potential

Sequences

Sequence LengthMass (Da)Tools
Q28125 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 63EA8C70913C2DF0

FASTA54459,735
        10         20         30         40         50         60 
MIASGPPPRV YWTSLIFLLL ACCLLPTGAQ GQTYQVRVEP KDPVVPFGEP LVVNCTLDCP 

        70         80         90        100        110        120 
GPGLISLETA LSKEPHSRGL GWAAFRLTNV TGDMEILCSG ICNKSQVVGF SNITVFGFPK 

       130        140        150        160        170        180 
RVELAPLPLW QPVGEELNLS CLVSGGAPRA HLSVVLLRGE EELGRQPLGK EEPAKVTFMV 

       190        200        210        220        230        240 
QPRREDHGTN FSCRSELDLR SQGLELFQNT SAPRKLQTYA MPKTAPRLVF PRFWEMETSW 

       250        260        270        280        290        300 
PVNCSLNGLF PASEAHIQLA LGNQMLNATV VSHADTLTAT ATAKTEQEGT QEIVCNVTLG 

       310        320        330        340        350        360 
VENRETRESL VAYRFQGPNL NLSESNATEG TPVTVTCAAG PQVQVMLDGV PAAVPGQPAQ 

       370        380        390        400        410        420 
LQLKATEMDD RRTFFCNATL KVHGVTLHRN RSIQLRVLYG PTIDRAKCPQ RLMWKEKTMH 

       430        440        450        460        470        480 
ILQCQARGNP NPQLQCLREG SKFKVPVGIP FLVLLNYSGT YSCQAASSRG TDKMLVMMDV 

       490        500        510        520        530        540 
QGRNPVTINI VLGVLAILGL VTLAAASVYV FWVQRQHDIY HLTPRSTRWR LTSTQPVTVA 


EELS 

« Hide

References

[1]"Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)."
Lee E.K., Kehrli M.E. Jr., Dietz A.B., Bosworth B.T., Reinhardt T.A.
Gene 174:311-313(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Holstein.
Tissue: Lymph node and Mammary gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41844 mRNA. Translation: AAB39264.1.
PIRJC5018.
RefSeqNP_776774.1. NM_174349.1.
UniGeneBt.4293.

3D structure databases

ProteinModelPortalQ28125.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000020903.

Proteomic databases

PRIDEQ28125.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281840.
KEGGbta:281840.

Organism-specific databases

CTD3385.

Phylogenomic databases

eggNOGNOG146347.
HOGENOMHOG000059554.
HOVERGENHBG052074.
InParanoidQ28125.
KOK06486.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805746.

Entry information

Entry nameICAM3_BOVIN
AccessionPrimary (citable) accession number: Q28125
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families