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Q28125

- ICAM3_BOVIN

UniProt

Q28125 - ICAM3_BOVIN

Protein

Intercellular adhesion molecule 3

Gene

ICAM3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2 By similarity.By similarity

    GO - Biological processi

    1. single organismal cell-cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intercellular adhesion molecule 3
    Short name:
    ICAM-3
    Alternative name(s):
    CD_antigen: CD50
    Gene namesi
    Name:ICAM3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 544513Intercellular adhesion molecule 3PRO_0000014793Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi55 ↔ 98Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi141 ↔ 193Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi244 ↔ 295Sequence Analysis
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi337 ↔ 376Sequence Analysis
    Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi424 ↔ 463Sequence Analysis
    Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ28125.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000020903.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28125.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 486455ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini512 – 54433CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei487 – 51125HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 10558Ig-like C2-type 1Add
    BLAST
    Domaini134 – 20067Ig-like C2-type 2Add
    BLAST
    Domaini237 – 30266Ig-like C2-type 3Add
    BLAST
    Domaini330 – 38354Ig-like C2-type 4Add
    BLAST
    Domaini417 – 47054Ig-like C2-type 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. ICAM family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146347.
    HOGENOMiHOG000059554.
    HOVERGENiHBG052074.
    InParanoidiQ28125.
    KOiK06486.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR003988. ICAM.
    IPR013768. ICAM_N.
    IPR003987. ICAM_VCAM_N.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    PfamiPF03921. ICAM_N. 1 hit.
    [Graphical view]
    PRINTSiPR01473. ICAM.
    PR01472. ICAMVCAM1.
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28125-1 [UniParc]FASTAAdd to Basket

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    MIASGPPPRV YWTSLIFLLL ACCLLPTGAQ GQTYQVRVEP KDPVVPFGEP    50
    LVVNCTLDCP GPGLISLETA LSKEPHSRGL GWAAFRLTNV TGDMEILCSG 100
    ICNKSQVVGF SNITVFGFPK RVELAPLPLW QPVGEELNLS CLVSGGAPRA 150
    HLSVVLLRGE EELGRQPLGK EEPAKVTFMV QPRREDHGTN FSCRSELDLR 200
    SQGLELFQNT SAPRKLQTYA MPKTAPRLVF PRFWEMETSW PVNCSLNGLF 250
    PASEAHIQLA LGNQMLNATV VSHADTLTAT ATAKTEQEGT QEIVCNVTLG 300
    VENRETRESL VAYRFQGPNL NLSESNATEG TPVTVTCAAG PQVQVMLDGV 350
    PAAVPGQPAQ LQLKATEMDD RRTFFCNATL KVHGVTLHRN RSIQLRVLYG 400
    PTIDRAKCPQ RLMWKEKTMH ILQCQARGNP NPQLQCLREG SKFKVPVGIP 450
    FLVLLNYSGT YSCQAASSRG TDKMLVMMDV QGRNPVTINI VLGVLAILGL 500
    VTLAAASVYV FWVQRQHDIY HLTPRSTRWR LTSTQPVTVA EELS 544
    Length:544
    Mass (Da):59,735
    Last modified:November 1, 1997 - v1
    Checksum:i63EA8C70913C2DF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41844 mRNA. Translation: AAB39264.1.
    PIRiJC5018.
    RefSeqiNP_776774.1. NM_174349.1.
    UniGeneiBt.4293.

    Genome annotation databases

    GeneIDi281840.
    KEGGibta:281840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41844 mRNA. Translation: AAB39264.1 .
    PIRi JC5018.
    RefSeqi NP_776774.1. NM_174349.1.
    UniGenei Bt.4293.

    3D structure databases

    ProteinModelPortali Q28125.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000020903.

    Proteomic databases

    PRIDEi Q28125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281840.
    KEGGi bta:281840.

    Organism-specific databases

    CTDi 3385.

    Phylogenomic databases

    eggNOGi NOG146347.
    HOGENOMi HOG000059554.
    HOVERGENi HBG052074.
    InParanoidi Q28125.
    KOi K06486.

    Miscellaneous databases

    NextBioi 20805746.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR003988. ICAM.
    IPR013768. ICAM_N.
    IPR003987. ICAM_VCAM_N.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    Pfami PF03921. ICAM_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01473. ICAM.
    PR01472. ICAMVCAM1.
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)."
      Lee E.K., Kehrli M.E. Jr., Dietz A.B., Bosworth B.T., Reinhardt T.A.
      Gene 174:311-313(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Holstein.
      Tissue: Lymph node and Mammary gland.

    Entry informationi

    Entry nameiICAM3_BOVIN
    AccessioniPrimary (citable) accession number: Q28125
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3