Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Intercellular adhesion molecule 3

Gene

ICAM3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 3
Short name:
ICAM-3
Alternative name(s):
CD_antigen: CD50
Gene namesi
Name:ICAM3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 486455ExtracellularSequence AnalysisAdd
BLAST
Transmembranei487 – 51125HelicalSequence AnalysisAdd
BLAST
Topological domaini512 – 54433CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 544513Intercellular adhesion molecule 3PRO_0000014793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi55 ↔ 98Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi141 ↔ 193Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi244 ↔ 295Sequence Analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi337 ↔ 376Sequence Analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi424 ↔ 463Sequence Analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ28125.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020903.

Structurei

3D structure databases

ProteinModelPortaliQ28125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 10558Ig-like C2-type 1Add
BLAST
Domaini134 – 20067Ig-like C2-type 2Add
BLAST
Domaini237 – 30266Ig-like C2-type 3Add
BLAST
Domaini330 – 38354Ig-like C2-type 4Add
BLAST
Domaini417 – 47054Ig-like C2-type 5Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146347.
HOGENOMiHOG000059554.
HOVERGENiHBG052074.
InParanoidiQ28125.
KOiK06486.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASGPPPRV YWTSLIFLLL ACCLLPTGAQ GQTYQVRVEP KDPVVPFGEP
60 70 80 90 100
LVVNCTLDCP GPGLISLETA LSKEPHSRGL GWAAFRLTNV TGDMEILCSG
110 120 130 140 150
ICNKSQVVGF SNITVFGFPK RVELAPLPLW QPVGEELNLS CLVSGGAPRA
160 170 180 190 200
HLSVVLLRGE EELGRQPLGK EEPAKVTFMV QPRREDHGTN FSCRSELDLR
210 220 230 240 250
SQGLELFQNT SAPRKLQTYA MPKTAPRLVF PRFWEMETSW PVNCSLNGLF
260 270 280 290 300
PASEAHIQLA LGNQMLNATV VSHADTLTAT ATAKTEQEGT QEIVCNVTLG
310 320 330 340 350
VENRETRESL VAYRFQGPNL NLSESNATEG TPVTVTCAAG PQVQVMLDGV
360 370 380 390 400
PAAVPGQPAQ LQLKATEMDD RRTFFCNATL KVHGVTLHRN RSIQLRVLYG
410 420 430 440 450
PTIDRAKCPQ RLMWKEKTMH ILQCQARGNP NPQLQCLREG SKFKVPVGIP
460 470 480 490 500
FLVLLNYSGT YSCQAASSRG TDKMLVMMDV QGRNPVTINI VLGVLAILGL
510 520 530 540
VTLAAASVYV FWVQRQHDIY HLTPRSTRWR LTSTQPVTVA EELS
Length:544
Mass (Da):59,735
Last modified:November 1, 1997 - v1
Checksum:i63EA8C70913C2DF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41844 mRNA. Translation: AAB39264.1.
PIRiJC5018.
RefSeqiNP_776774.1. NM_174349.1.
UniGeneiBt.4293.

Genome annotation databases

GeneIDi281840.
KEGGibta:281840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41844 mRNA. Translation: AAB39264.1.
PIRiJC5018.
RefSeqiNP_776774.1. NM_174349.1.
UniGeneiBt.4293.

3D structure databases

ProteinModelPortaliQ28125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020903.

Proteomic databases

PRIDEiQ28125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281840.
KEGGibta:281840.

Organism-specific databases

CTDi3385.

Phylogenomic databases

eggNOGiNOG146347.
HOGENOMiHOG000059554.
HOVERGENiHBG052074.
InParanoidiQ28125.
KOiK06486.

Miscellaneous databases

NextBioi20805746.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)."
    Lee E.K., Kehrli M.E. Jr., Dietz A.B., Bosworth B.T., Reinhardt T.A.
    Gene 174:311-313(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein.
    Tissue: Lymph node and Mammary gland.

Entry informationi

Entry nameiICAM3_BOVIN
AccessioniPrimary (citable) accession number: Q28125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.