Q28125 (ICAM3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Intercellular adhesion molecule 3
Short name=ICAM-3

Alternative name(s):
CD_antigen=CD50

Gene names

Name:

ICAM3

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 544	513	Intercellular adhesion molecule 3		PRO_0000014793
Regions
	Topological domain	32 – 486	455	Extracellular Potential
	Transmembrane	487 – 511	25	Helical; Potential
	Topological domain	512 – 544	33	Cytoplasmic Potential
	Domain	48 – 105	58	Ig-like C2-type 1
	Domain	134 – 200	67	Ig-like C2-type 2
	Domain	237 – 302	66	Ig-like C2-type 3
	Domain	330 – 383	54	Ig-like C2-type 4
	Domain	417 – 470	54	Ig-like C2-type 5
Amino acid modifications
	Glycosylation	54	1	N-linked (GlcNAc...) Potential
	Glycosylation	89	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Glycosylation	209	1	N-linked (GlcNAc...) Potential
	Glycosylation	243	1	N-linked (GlcNAc...) Potential
	Glycosylation	267	1	N-linked (GlcNAc...) Potential
	Glycosylation	296	1	N-linked (GlcNAc...) Potential
	Glycosylation	321	1	N-linked (GlcNAc...) Potential
	Glycosylation	326	1	N-linked (GlcNAc...) Potential
	Glycosylation	377	1	N-linked (GlcNAc...) Potential
	Glycosylation	390	1	N-linked (GlcNAc...) Potential
	Glycosylation	456	1	N-linked (GlcNAc...) Potential
	Disulfide bond	55 ↔ 98		Potential
	Disulfide bond	141 ↔ 193		Potential
	Disulfide bond	244 ↔ 295		Potential
	Disulfide bond	337 ↔ 376		Potential
	Disulfide bond	424 ↔ 463		Potential

Sequences

	Sequence		Length	Mass (Da)
	Q28125 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 63EA8C70913C2DF0	FASTA	544	59,735
	10 20 30 40 50 60 MIASGPPPRV YWTSLIFLLL ACCLLPTGAQ GQTYQVRVEP KDPVVPFGEP LVVNCTLDCP 70 80 90 100 110 120 GPGLISLETA LSKEPHSRGL GWAAFRLTNV TGDMEILCSG ICNKSQVVGF SNITVFGFPK 130 140 150 160 170 180 RVELAPLPLW QPVGEELNLS CLVSGGAPRA HLSVVLLRGE EELGRQPLGK EEPAKVTFMV 190 200 210 220 230 240 QPRREDHGTN FSCRSELDLR SQGLELFQNT SAPRKLQTYA MPKTAPRLVF PRFWEMETSW 250 260 270 280 290 300 PVNCSLNGLF PASEAHIQLA LGNQMLNATV VSHADTLTAT ATAKTEQEGT QEIVCNVTLG 310 320 330 340 350 360 VENRETRESL VAYRFQGPNL NLSESNATEG TPVTVTCAAG PQVQVMLDGV PAAVPGQPAQ 370 380 390 400 410 420 LQLKATEMDD RRTFFCNATL KVHGVTLHRN RSIQLRVLYG PTIDRAKCPQ RLMWKEKTMH 430 440 450 460 470 480 ILQCQARGNP NPQLQCLREG SKFKVPVGIP FLVLLNYSGT YSCQAASSRG TDKMLVMMDV 490 500 510 520 530 540 QGRNPVTINI VLGVLAILGL VTLAAASVYV FWVQRQHDIY HLTPRSTRWR LTSTQPVTVA EELS

References

[1]

"Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)." Lee E.K., Kehrli M.E. Jr., Dietz A.B., Bosworth B.T., Reinhardt T.A. Gene 174:311-313(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Holstein. Tissue: Lymph node and Mammary gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L41844 mRNA. Translation: AAB39264.1.
IPI	IPI00697034.
PIR	JC5018.
RefSeq	NP_776774.1. NM_174349.1.
UniGene	Bt.4293.
3D structure databases
ProteinModelPortal	Q28125.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000020903.
Proteomic databases
PRIDE	Q28125.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	281840.
KEGG	bta:281840.
Organism-specific databases
CTD	3385.
Phylogenomic databases
eggNOG	NOG146347.
HOGENOM	HOG000059554.
HOVERGEN	HBG052074.
InParanoid	Q28125.
KO	K06486.
OrthoDB	EOG4THVT8.
Family and domain databases
Gene3D	2.60.40.10. 5 hits.
InterPro	IPR003988. ICAM. IPR013768. ICAM_N. IPR003987. ICAM_VCAM_N. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
Pfam	PF03921. ICAM_N. 1 hit. [Graphical view]
PRINTS	PR01473. ICAM. PR01472. ICAMVCAM1.
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805746.

Entry information

Entry name

ICAM3_BOVIN

Accession

Primary (citable) accession number: Q28125

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program