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Protein

Intercellular adhesion molecule 3

Gene

ICAM3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 3
Short name:
ICAM-3
Alternative name(s):
CD_antigen: CD50
Gene namesi
Name:ICAM3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 486ExtracellularSequence analysisAdd BLAST455
Transmembranei487 – 511HelicalSequence analysisAdd BLAST25
Topological domaini512 – 544CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001479332 – 544Intercellular adhesion molecule 3Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi55 ↔ 98PROSITE-ProRule annotationBy similarity
Disulfide bondi59 ↔ 102By similarity
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi141 ↔ 193By similarity
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1
Glycosylationi243N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi244 ↔ 295Sequence analysis
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Glycosylationi326N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi337 ↔ 376Sequence analysis
Glycosylationi377N-linked (GlcNAc...)Sequence analysis1
Glycosylationi390N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi424 ↔ 463Sequence analysis
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28125.

Expressioni

Tissue specificityi

Leukocytes.By similarity

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020903.

Structurei

3D structure databases

ProteinModelPortaliQ28125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 105Ig-like C2-type 1Add BLAST58
Domaini134 – 200Ig-like C2-type 2Add BLAST67
Domaini237 – 302Ig-like C2-type 3Add BLAST66
Domaini330 – 383Ig-like C2-type 4Add BLAST54
Domaini417 – 470Ig-like C2-type 5Add BLAST54

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPHM. Eukaryota.
ENOG410YQ1Q. LUCA.
HOGENOMiHOG000059554.
HOVERGENiHBG052074.
InParanoidiQ28125.
KOiK06486.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASGPPPRV YWTSLIFLLL ACCLLPTGAQ GQTYQVRVEP KDPVVPFGEP
60 70 80 90 100
LVVNCTLDCP GPGLISLETA LSKEPHSRGL GWAAFRLTNV TGDMEILCSG
110 120 130 140 150
ICNKSQVVGF SNITVFGFPK RVELAPLPLW QPVGEELNLS CLVSGGAPRA
160 170 180 190 200
HLSVVLLRGE EELGRQPLGK EEPAKVTFMV QPRREDHGTN FSCRSELDLR
210 220 230 240 250
SQGLELFQNT SAPRKLQTYA MPKTAPRLVF PRFWEMETSW PVNCSLNGLF
260 270 280 290 300
PASEAHIQLA LGNQMLNATV VSHADTLTAT ATAKTEQEGT QEIVCNVTLG
310 320 330 340 350
VENRETRESL VAYRFQGPNL NLSESNATEG TPVTVTCAAG PQVQVMLDGV
360 370 380 390 400
PAAVPGQPAQ LQLKATEMDD RRTFFCNATL KVHGVTLHRN RSIQLRVLYG
410 420 430 440 450
PTIDRAKCPQ RLMWKEKTMH ILQCQARGNP NPQLQCLREG SKFKVPVGIP
460 470 480 490 500
FLVLLNYSGT YSCQAASSRG TDKMLVMMDV QGRNPVTINI VLGVLAILGL
510 520 530 540
VTLAAASVYV FWVQRQHDIY HLTPRSTRWR LTSTQPVTVA EELS
Length:544
Mass (Da):59,735
Last modified:November 1, 1997 - v1
Checksum:i63EA8C70913C2DF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41844 mRNA. Translation: AAB39264.1.
PIRiJC5018.
RefSeqiNP_776774.1. NM_174349.1.
UniGeneiBt.4293.

Genome annotation databases

GeneIDi281840.
KEGGibta:281840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41844 mRNA. Translation: AAB39264.1.
PIRiJC5018.
RefSeqiNP_776774.1. NM_174349.1.
UniGeneiBt.4293.

3D structure databases

ProteinModelPortaliQ28125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020903.

Proteomic databases

PaxDbiQ28125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281840.
KEGGibta:281840.

Organism-specific databases

CTDi3385.

Phylogenomic databases

eggNOGiENOG410IPHM. Eukaryota.
ENOG410YQ1Q. LUCA.
HOGENOMiHOG000059554.
HOVERGENiHBG052074.
InParanoidiQ28125.
KOiK06486.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiICAM3_BOVIN
AccessioniPrimary (citable) accession number: Q28125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.