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Protein

Intercellular adhesion molecule 3

Gene

ICAM3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 3
Short name:
ICAM-3
Alternative name(s):
CD_antigen: CD50
Gene namesi
Name:ICAM3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 486ExtracellularSequence analysisAdd BLAST455
Transmembranei487 – 511HelicalSequence analysisAdd BLAST25
Topological domaini512 – 544CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001479332 – 544Intercellular adhesion molecule 3Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi55 ↔ 98PROSITE-ProRule annotationBy similarity
Disulfide bondi59 ↔ 102By similarity
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi141 ↔ 193By similarity
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 295Sequence analysis
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi337 ↔ 376Sequence analysis
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi424 ↔ 463Sequence analysis
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28125
PRIDEiQ28125

Expressioni

Tissue specificityi

Leukocytes.By similarity

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020903

Structurei

3D structure databases

ProteinModelPortaliQ28125
SMRiQ28125
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 105Ig-like C2-type 1Add BLAST58
Domaini134 – 200Ig-like C2-type 2Add BLAST67
Domaini237 – 302Ig-like C2-type 3Add BLAST66
Domaini330 – 383Ig-like C2-type 4Add BLAST54
Domaini417 – 470Ig-like C2-type 5Add BLAST54

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA
HOGENOMiHOG000059554
HOVERGENiHBG052074
InParanoidiQ28125
KOiK06486

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SMARTiView protein in SMART
SM00409 IG, 4 hits
SUPFAMiSSF48726 SSF48726, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASGPPPRV YWTSLIFLLL ACCLLPTGAQ GQTYQVRVEP KDPVVPFGEP
60 70 80 90 100
LVVNCTLDCP GPGLISLETA LSKEPHSRGL GWAAFRLTNV TGDMEILCSG
110 120 130 140 150
ICNKSQVVGF SNITVFGFPK RVELAPLPLW QPVGEELNLS CLVSGGAPRA
160 170 180 190 200
HLSVVLLRGE EELGRQPLGK EEPAKVTFMV QPRREDHGTN FSCRSELDLR
210 220 230 240 250
SQGLELFQNT SAPRKLQTYA MPKTAPRLVF PRFWEMETSW PVNCSLNGLF
260 270 280 290 300
PASEAHIQLA LGNQMLNATV VSHADTLTAT ATAKTEQEGT QEIVCNVTLG
310 320 330 340 350
VENRETRESL VAYRFQGPNL NLSESNATEG TPVTVTCAAG PQVQVMLDGV
360 370 380 390 400
PAAVPGQPAQ LQLKATEMDD RRTFFCNATL KVHGVTLHRN RSIQLRVLYG
410 420 430 440 450
PTIDRAKCPQ RLMWKEKTMH ILQCQARGNP NPQLQCLREG SKFKVPVGIP
460 470 480 490 500
FLVLLNYSGT YSCQAASSRG TDKMLVMMDV QGRNPVTINI VLGVLAILGL
510 520 530 540
VTLAAASVYV FWVQRQHDIY HLTPRSTRWR LTSTQPVTVA EELS
Length:544
Mass (Da):59,735
Last modified:November 1, 1997 - v1
Checksum:i63EA8C70913C2DF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41844 mRNA Translation: AAB39264.1
PIRiJC5018
RefSeqiNP_776774.1, NM_174349.1
UniGeneiBt.4293

Genome annotation databases

GeneIDi281840
KEGGibta:281840

Similar proteinsi

Entry informationi

Entry nameiICAM3_BOVIN
AccessioniPrimary (citable) accession number: Q28125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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