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Q28125

- ICAM3_BOVIN

UniProt

Q28125 - ICAM3_BOVIN

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Protein

Intercellular adhesion molecule 3

Gene

ICAM3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2 (By similarity).By similarity

GO - Biological processi

  1. single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 3
Short name:
ICAM-3
Alternative name(s):
CD_antigen: CD50
Gene namesi
Name:ICAM3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 544513Intercellular adhesion molecule 3PRO_0000014793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi55 ↔ 98Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi141 ↔ 193Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi244 ↔ 295Sequence Analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi337 ↔ 376Sequence Analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi424 ↔ 463Sequence Analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ28125.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020903.

Structurei

3D structure databases

ProteinModelPortaliQ28125.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 486455ExtracellularSequence AnalysisAdd
BLAST
Topological domaini512 – 54433CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei487 – 51125HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 10558Ig-like C2-type 1Add
BLAST
Domaini134 – 20067Ig-like C2-type 2Add
BLAST
Domaini237 – 30266Ig-like C2-type 3Add
BLAST
Domaini330 – 38354Ig-like C2-type 4Add
BLAST
Domaini417 – 47054Ig-like C2-type 5Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146347.
HOGENOMiHOG000059554.
HOVERGENiHBG052074.
InParanoidiQ28125.
KOiK06486.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28125-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIASGPPPRV YWTSLIFLLL ACCLLPTGAQ GQTYQVRVEP KDPVVPFGEP
60 70 80 90 100
LVVNCTLDCP GPGLISLETA LSKEPHSRGL GWAAFRLTNV TGDMEILCSG
110 120 130 140 150
ICNKSQVVGF SNITVFGFPK RVELAPLPLW QPVGEELNLS CLVSGGAPRA
160 170 180 190 200
HLSVVLLRGE EELGRQPLGK EEPAKVTFMV QPRREDHGTN FSCRSELDLR
210 220 230 240 250
SQGLELFQNT SAPRKLQTYA MPKTAPRLVF PRFWEMETSW PVNCSLNGLF
260 270 280 290 300
PASEAHIQLA LGNQMLNATV VSHADTLTAT ATAKTEQEGT QEIVCNVTLG
310 320 330 340 350
VENRETRESL VAYRFQGPNL NLSESNATEG TPVTVTCAAG PQVQVMLDGV
360 370 380 390 400
PAAVPGQPAQ LQLKATEMDD RRTFFCNATL KVHGVTLHRN RSIQLRVLYG
410 420 430 440 450
PTIDRAKCPQ RLMWKEKTMH ILQCQARGNP NPQLQCLREG SKFKVPVGIP
460 470 480 490 500
FLVLLNYSGT YSCQAASSRG TDKMLVMMDV QGRNPVTINI VLGVLAILGL
510 520 530 540
VTLAAASVYV FWVQRQHDIY HLTPRSTRWR LTSTQPVTVA EELS
Length:544
Mass (Da):59,735
Last modified:November 1, 1997 - v1
Checksum:i63EA8C70913C2DF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41844 mRNA. Translation: AAB39264.1.
PIRiJC5018.
RefSeqiNP_776774.1. NM_174349.1.
UniGeneiBt.4293.

Genome annotation databases

GeneIDi281840.
KEGGibta:281840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41844 mRNA. Translation: AAB39264.1 .
PIRi JC5018.
RefSeqi NP_776774.1. NM_174349.1.
UniGenei Bt.4293.

3D structure databases

ProteinModelPortali Q28125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000020903.

Proteomic databases

PRIDEi Q28125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281840.
KEGGi bta:281840.

Organism-specific databases

CTDi 3385.

Phylogenomic databases

eggNOGi NOG146347.
HOGENOMi HOG000059554.
HOVERGENi HBG052074.
InParanoidi Q28125.
KOi K06486.

Miscellaneous databases

NextBioi 20805746.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
Pfami PF03921. ICAM_N. 1 hit.
[Graphical view ]
PRINTSi PR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)."
    Lee E.K., Kehrli M.E. Jr., Dietz A.B., Bosworth B.T., Reinhardt T.A.
    Gene 174:311-313(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein.
    Tissue: Lymph node and Mammary gland.

Entry informationi

Entry nameiICAM3_BOVIN
AccessioniPrimary (citable) accession number: Q28125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3