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Q28120

- QPCT_BOVIN

UniProt

Q28120 - QPCT_BOVIN

Protein

Glutaminyl-peptide cyclotransferase

Gene

QPCT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation By similarity.By similarity

    Catalytic activityi

    L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi159 – 1591Zinc; catalyticBy similarity
    Active sitei201 – 2011Proton acceptorBy similarity
    Metal bindingi202 – 2021Zinc; catalyticBy similarity
    Active sitei248 – 2481Proton acceptorBy similarity
    Metal bindingi330 – 3301Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. glutaminyl-peptide cyclotransferase activity Source: UniProtKB
    2. peptidase activity Source: InterPro
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM28.974.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaminyl-peptide cyclotransferase (EC:2.3.2.5)
    Alternative name(s):
    Glutaminyl cyclase
    Short name:
    QC
    Glutaminyl-tRNA cyclotransferase
    Gene namesi
    Name:QPCT
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 361333Glutaminyl-peptide cyclotransferasePRO_0000022194Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi139 ↔ 164By similarity
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ28120.

    Expressioni

    Tissue specificityi

    Expressed mainly in brain tissue.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28120.
    SMRiQ28120. Positions 33-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG298226.
    HOGENOMiHOG000189291.
    HOVERGENiHBG009812.
    InParanoidiQ28120.
    KOiK00683.

    Family and domain databases

    InterProiIPR007484. Peptidase_M28.
    [Graphical view]
    PfamiPF04389. Peptidase_M28. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28120-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGCRDPRVV DTLHLLLLVA VLPLAVSGVR RGAVDWTQEK NYHQPALLNV    50
    SSLRQVAEGT SISEMWQNDL RPLLIERYPG SPGSFAARQH IMQRIQRLQA 100
    DWVLEVDTFL SQTPYGYRSF SNIISTLNPT AKRHLVLACH YDSKYFPHWD 150
    DRVFVGATDS AVPCAMMLEL ARALDKQLFS LKNISDSRPD LSLQLIFFDG 200
    EEAFHLWSPQ DSLYGSRHLA SKMASTPHPP GARDTNQLHG MDLLVLLDLI 250
    GAPFPTFPNF FPNTARWFGR LEAIEHGLRE LGLLKDHSSE RWYFRNYGYG 300
    GVIQDDHIPF LRRGVPVLHL ISSPFPEVWH TMDDNEENLD RTTIDNLNKI 350
    LQVFVLEYLH L 361
    Length:361
    Mass (Da):41,224
    Last modified:November 1, 1997 - v1
    Checksum:iEF72BE77C07369DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80626 mRNA. Translation: AAA30549.1.
    PIRiA41535.
    RefSeqiNP_803472.1. NM_177506.2.
    UniGeneiBt.412.

    Genome annotation databases

    GeneIDi281437.
    KEGGibta:281437.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80626 mRNA. Translation: AAA30549.1 .
    PIRi A41535.
    RefSeqi NP_803472.1. NM_177506.2.
    UniGenei Bt.412.

    3D structure databases

    ProteinModelPortali Q28120.
    SMRi Q28120. Positions 33-361.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M28.974.

    Proteomic databases

    PRIDEi Q28120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281437.
    KEGGi bta:281437.

    Organism-specific databases

    CTDi 25797.

    Phylogenomic databases

    eggNOGi NOG298226.
    HOGENOMi HOG000189291.
    HOVERGENi HBG009812.
    InParanoidi Q28120.
    KOi K00683.

    Miscellaneous databases

    NextBioi 20805423.

    Family and domain databases

    InterProi IPR007484. Peptidase_M28.
    [Graphical view ]
    Pfami PF04389. Peptidase_M28. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and functional expression of a glutaminyl cyclase."
      Pohl T., Zimmer M., Mugele K., Spiess J.
      Proc. Natl. Acad. Sci. U.S.A. 88:10059-10063(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiQPCT_BOVIN
    AccessioniPrimary (citable) accession number: Q28120
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3