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Q28120 (QPCT_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaminyl-peptide cyclotransferase

EC=2.3.2.5
Alternative name(s):
Glutaminyl cyclase
Short name=QC
Glutaminyl-tRNA cyclotransferase
Gene names
Name:QPCT
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation By similarity.

Catalytic activity

L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed mainly in brain tissue.

Sequence similarities

Belongs to the glutaminyl-peptide cyclotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 361333Glutaminyl-peptide cyclotransferase
PRO_0000022194

Sites

Active site2011Proton acceptor By similarity
Active site2481Proton acceptor By similarity
Metal binding1591Zinc; catalytic By similarity
Metal binding2021Zinc; catalytic By similarity
Metal binding3301Zinc; catalytic By similarity

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Disulfide bond139 ↔ 164 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28120 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: EF72BE77C07369DA

FASTA36141,224
        10         20         30         40         50         60 
MAGCRDPRVV DTLHLLLLVA VLPLAVSGVR RGAVDWTQEK NYHQPALLNV SSLRQVAEGT 

        70         80         90        100        110        120 
SISEMWQNDL RPLLIERYPG SPGSFAARQH IMQRIQRLQA DWVLEVDTFL SQTPYGYRSF 

       130        140        150        160        170        180 
SNIISTLNPT AKRHLVLACH YDSKYFPHWD DRVFVGATDS AVPCAMMLEL ARALDKQLFS 

       190        200        210        220        230        240 
LKNISDSRPD LSLQLIFFDG EEAFHLWSPQ DSLYGSRHLA SKMASTPHPP GARDTNQLHG 

       250        260        270        280        290        300 
MDLLVLLDLI GAPFPTFPNF FPNTARWFGR LEAIEHGLRE LGLLKDHSSE RWYFRNYGYG 

       310        320        330        340        350        360 
GVIQDDHIPF LRRGVPVLHL ISSPFPEVWH TMDDNEENLD RTTIDNLNKI LQVFVLEYLH 


L 

« Hide

References

[1]"Primary structure and functional expression of a glutaminyl cyclase."
Pohl T., Zimmer M., Mugele K., Spiess J.
Proc. Natl. Acad. Sci. U.S.A. 88:10059-10063(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80626 mRNA. Translation: AAA30549.1.
PIRA41535.
RefSeqNP_803472.1. NM_177506.2.
UniGeneBt.412.

3D structure databases

ProteinModelPortalQ28120.
SMRQ28120. Positions 33-361.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSM28.974.

Proteomic databases

PRIDEQ28120.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281437.
KEGGbta:281437.

Organism-specific databases

CTD25797.

Phylogenomic databases

eggNOGNOG298226.
HOGENOMHOG000189291.
HOVERGENHBG009812.
InParanoidQ28120.
KOK00683.

Family and domain databases

InterProIPR007484. Peptidase_M28.
[Graphical view]
PfamPF04389. Peptidase_M28. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805423.

Entry information

Entry nameQPCT_BOVIN
AccessionPrimary (citable) accession number: Q28120
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 22, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families