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Q28120

- QPCT_BOVIN

UniProt

Q28120 - QPCT_BOVIN

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Protein
Glutaminyl-peptide cyclotransferase
Gene
QPCT
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation By similarity.

Catalytic activityi

L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi159 – 1591Zinc; catalytic By similarity
Active sitei201 – 2011Proton acceptor By similarity
Metal bindingi202 – 2021Zinc; catalytic By similarity
Active sitei248 – 2481Proton acceptor By similarity
Metal bindingi330 – 3301Zinc; catalytic By similarity

GO - Molecular functioni

  1. glutaminyl-peptide cyclotransferase activity Source: UniProtKB
  2. peptidase activity Source: InterPro
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM28.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminyl-peptide cyclotransferase (EC:2.3.2.5)
Alternative name(s):
Glutaminyl cyclase
Short name:
QC
Glutaminyl-tRNA cyclotransferase
Gene namesi
Name:QPCT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 361333Glutaminyl-peptide cyclotransferase
PRO_0000022194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi139 ↔ 164 By similarity
Glycosylationi183 – 1831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ28120.

Expressioni

Tissue specificityi

Expressed mainly in brain tissue.

Structurei

3D structure databases

ProteinModelPortaliQ28120.
SMRiQ28120. Positions 33-361.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG298226.
HOGENOMiHOG000189291.
HOVERGENiHBG009812.
InParanoidiQ28120.
KOiK00683.

Family and domain databases

InterProiIPR007484. Peptidase_M28.
[Graphical view]
PfamiPF04389. Peptidase_M28. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28120-1 [UniParc]FASTAAdd to Basket

« Hide

MAGCRDPRVV DTLHLLLLVA VLPLAVSGVR RGAVDWTQEK NYHQPALLNV    50
SSLRQVAEGT SISEMWQNDL RPLLIERYPG SPGSFAARQH IMQRIQRLQA 100
DWVLEVDTFL SQTPYGYRSF SNIISTLNPT AKRHLVLACH YDSKYFPHWD 150
DRVFVGATDS AVPCAMMLEL ARALDKQLFS LKNISDSRPD LSLQLIFFDG 200
EEAFHLWSPQ DSLYGSRHLA SKMASTPHPP GARDTNQLHG MDLLVLLDLI 250
GAPFPTFPNF FPNTARWFGR LEAIEHGLRE LGLLKDHSSE RWYFRNYGYG 300
GVIQDDHIPF LRRGVPVLHL ISSPFPEVWH TMDDNEENLD RTTIDNLNKI 350
LQVFVLEYLH L 361
Length:361
Mass (Da):41,224
Last modified:November 1, 1997 - v1
Checksum:iEF72BE77C07369DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80626 mRNA. Translation: AAA30549.1.
PIRiA41535.
RefSeqiNP_803472.1. NM_177506.2.
UniGeneiBt.412.

Genome annotation databases

GeneIDi281437.
KEGGibta:281437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80626 mRNA. Translation: AAA30549.1 .
PIRi A41535.
RefSeqi NP_803472.1. NM_177506.2.
UniGenei Bt.412.

3D structure databases

ProteinModelPortali Q28120.
SMRi Q28120. Positions 33-361.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M28.974.

Proteomic databases

PRIDEi Q28120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281437.
KEGGi bta:281437.

Organism-specific databases

CTDi 25797.

Phylogenomic databases

eggNOGi NOG298226.
HOGENOMi HOG000189291.
HOVERGENi HBG009812.
InParanoidi Q28120.
KOi K00683.

Miscellaneous databases

NextBioi 20805423.

Family and domain databases

InterProi IPR007484. Peptidase_M28.
[Graphical view ]
Pfami PF04389. Peptidase_M28. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure and functional expression of a glutaminyl cyclase."
    Pohl T., Zimmer M., Mugele K., Spiess J.
    Proc. Natl. Acad. Sci. U.S.A. 88:10059-10063(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiQPCT_BOVIN
AccessioniPrimary (citable) accession number: Q28120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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