Reviewed, UniProtKB/Swiss-Prot Q28120 (QPCT_BOVIN)

Names and origin

Protein names

Recommended name:
    Glutaminyl-peptide cyclotransferase
    EC=2.3.2.5
Alternative name(s):
    Glutaminyl-tRNA cyclotransferase
      Short name=Glutaminyl cyclase
    QC

Gene names

Name:

QPCT

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation By similarity.
Catalytic activity	L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Tissue specificity	Expressed mainly in brain tissue.
Sequence similarities	Belongs to the glutaminyl-peptide cyclotransferase family.

Ontologies

Keywords
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW glutaminyl-peptide cyclotransferase activity Inferred from electronic annotation. Source: EC peptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 361	333	Glutaminyl-peptide cyclotransferase		PRO_0000022194
Sites
	Active site	201	1	Proton acceptor By similarity
	Metal binding	159	1	Zinc By similarity
	Metal binding	202	1	Zinc By similarity
	Metal binding	330	1	Zinc By similarity
Amino acid modifications
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q28120-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: EF72BE77C07369DA	FASTA	361	41,224
	10 20 30 40 50 60 MAGCRDPRVV DTLHLLLLVA VLPLAVSGVR RGAVDWTQEK NYHQPALLNV SSLRQVAEGT 70 80 90 100 110 120 SISEMWQNDL RPLLIERYPG SPGSFAARQH IMQRIQRLQA DWVLEVDTFL SQTPYGYRSF 130 140 150 160 170 180 SNIISTLNPT AKRHLVLACH YDSKYFPHWD DRVFVGATDS AVPCAMMLEL ARALDKQLFS 190 200 210 220 230 240 LKNISDSRPD LSLQLIFFDG EEAFHLWSPQ DSLYGSRHLA SKMASTPHPP GARDTNQLHG 250 260 270 280 290 300 MDLLVLLDLI GAPFPTFPNF FPNTARWFGR LEAIEHGLRE LGLLKDHSSE RWYFRNYGYG 310 320 330 340 350 360 GVIQDDHIPF LRRGVPVLHL ISSPFPEVWH TMDDNEENLD RTTIDNLNKI LQVFVLEYLH L

References

[1]	"Primary structure and functional expression of a glutaminyl cyclase." Pohl T., Zimmer M., Mugele K., Spiess J. Proc. Natl. Acad. Sci. U.S.A. 88:10059-10063(1991) [PubMed: 1946423] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M80626 mRNA. Translation: AAA30549.1.
IPI	IPI00700666.
PIR	A41535.
RefSeq	NP_803472.1.
UniGene	Bt.412
3D structure databases
SMR	Q28120. Positions 33-361.
ModBase	Search...
Protein-protein interaction databases
STRING	Q28120.
Protein family/group databases
MEROPS	M28.974.
Genome annotation databases
Ensembl	ENSBTAT00000018493; ENSBTAP00000018493; ENSBTAG00000013923; Bos taurus. [Genome view]
GeneID	281437.
KEGG	bta:281437.
Organism-specific databases
CTD	281437.
Phylogenomic databases
HOVERGEN	Q28120.
Enzyme and pathway databases
BRENDA	2.3.2.5. 251.
Family and domain databases
InterPro	IPR007484. Peptidase_M28. [Graphical view]
Pfam	PF04389. Peptidase_M28. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QPCT_BOVIN

Accession

Primary (citable) accession number: Q28120

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	September 1, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)