Reviewed, UniProtKB/Swiss-Prot Q28113 (FUT2_BOVIN)

Names and origin

Protein names

Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 2
    EC=2.4.1.69
Alternative name(s):
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
    Alpha(1,2)FT 2
    Fucosyltransferase 2

Gene names

Name:

FUT2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	galactoside 2-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Galactoside 2-alpha-L-fucosyltransferase 2		PRO_0000149106
Regions
	Topological domain	1 – 7	7	Cytoplasmic Potential
	Transmembrane	8 – 28	21	Signal-anchor for type II membrane protein Potential
	Topological domain	29 – 344	316	Lumenal Potential
Amino acid modifications
	Glycosylation	189	1	N-linked (GlcNAc...) Potential
	Glycosylation	255	1	N-linked (GlcNAc...) Potential
	Glycosylation	283	1	N-linked (GlcNAc...) Potential
	Glycosylation	309	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q28113-1 [UniParc]. Last modified January 1, 1998. Version 2. Checksum: F35AC33F1B7B9F68	FASTA	344	39,320
	10 20 30 40 50 60 MFSTQTFFFF PTAPFILFVF TASTIFHLHQ RLEKMQPTWE LEALEPATME TPSRPQPRPQ 70 80 90 100 110 120 LKGMWTINAI GRLGNQMGEY ATLYALAKMN GRAAFIPPQM HSTLAPIFRI TLPVLHDATA 130 140 150 160 170 180 RSVPWQNYHL NDWMEEQYRH IPGEYVRLTG YPCSWTFYHH LRAEILQEFT LHAHVREEAQ 190 200 210 220 230 240 NFLRGLRVNG SRPSTYVGVH VRRGDYVHVM PNVWKGVVAD RRYLEQALDW FRARYSAPIF 250 260 270 280 290 300 VVSSNGMAWC RENINASRGD VVFAGNGNEG SPAKDFALLT QCNHTIMTIG TFGIWAAYLA 310 320 330 340 GGETIYLANY TLPDSPFLKI FKPEAAFLPK WIGIPADLSP LLKH

References

[1]	Petit J.-M. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99620 Genomic DNA. Translation: CAA67931.1.
IPI	IPI00700406.
RefSeq	NP_803466.1.
UniGene	Bt.21655
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q28113.
Protein family/group databases
CAZy	GT11. Glycosyltransferase Family 11.
Genome annotation databases
Ensembl	ENSBTAT00000028720; ENSBTAP00000028720; ENSBTAG00000021557; Bos taurus. [Genome view]
GeneID	281175.
KEGG	bta:281175.
Organism-specific databases
CTD	281175.
Phylogenomic databases
eggNOG	maNOG09331.
HOVERGEN	Q28113.
InParanoid	Q28113.
Enzyme and pathway databases
BRENDA	2.4.1.69. 251.
Family and domain databases
InterPro	IPR002516. Glyco_trans_11. [Graphical view]
PANTHER	PTHR11927. Glyco_trans_11. 1 hit.
Pfam	PF01531. Glyco_transf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT2_BOVIN

Accession

Primary (citable) accession number: Q28113

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	January 19, 2010
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)